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Seasonal variations of nonmotor symptoms in patients with Parkinson's disease in Southeast China

Chinese Medical Journal 2023年第4期136卷 415-422页

作者： Jingyi Wang Kangping Xiong Jingyuan Chao Sheng Zhuang Jie Li Chunfeng Liu Department of Neurology and Clinical Research Center of Neurological Disease The Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu 215004China Sleep Center The Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu 215004China Institute of Neuroscience Soochow UniversitySuzhouJiangsu 215123China

Background:Studies suggest seasonal fluctuations of symptoms in Parkinson’s disease(PD)patients in Western ***,the association between seasonal change and variation in nonmotor symptoms(NMS)in Chinese PD patients is ***,we studied whether there is a change rule with annual cycle with severity of NMS for patients with PD in Southeast ***:We studied 1005 PD patients between April 2008 and October *** were classified into four seasons according to the 24 Chinese solar terms,based on assessment *** compared comprehensive NMS scales and polysomnography parameters among groups and conducted further analysis of disease ***:Among the 1005 patients studied,the mean age was 64.2±9.7 years and 569(56.6%)of them were *** to the summer group,patients assessed during winter had higher Scales for Outcomes in Parkinson’s disease-Autonomic Dysfunction(SCOPA-AUT)scores(P=0.045).The sleep efficiency factor scores of Pittsburgh Sleep Quality Index in patients were higher during spring than summer(P=0.009).Among patients who completed polysomnography during the same period(n=135),compared with summer follow-ups,we observed a higher percentage of NREMS1 in winter and spring follow-ups(P=0.042,P=0.011),a higher NREMS1 time in spring follow-ups(P=0.0024),a lower NREMS2 time in winter follow-ups(P=0.007),and a higher percentage of phasic rapid eye movement(REM)-sleep without atonia in autumn and winter follow-ups(P=0.026 and P=0.020,respectively).In a subset of patients with PD and REM sleep behavior disorder(RBD;n=182),those visited during winter had higher scores for RBD questionnaire-Hong Kong and its factor 1(dream-related sub-score)than those visited during summer(P=0.034,P=0.020).We observed similar findings for SCOPA-AUT and sleep efficiency factor scores in early stage patients in subgroup ***:PD patients assessed for follow-up during summer showed less severe symptoms of autonomic dysfunction and

关键词： nonmotor symptoms Parkinson’s disease Seasonal variations

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Target Selection Recommendations Based on Impact of Deep Brain Stimulation Surgeries on nonmotor symptoms of Parkinson＇s Disease

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Chinese Medical Journal 2015年第24期128卷 3371-3380页

作者： Xiao-Hong Wang Lin Zhang Laura Sperry John Olichney Sarah Tomaszewski Farias Kiarash Shahlaie Norika Malhado Chang Ying Liu Su-Ping Wang Cui Wang Department of Neurology Dalian Municipal Central Hospital Dalian Liaoning 116033 China Department of Neurology University of California Davis Sacramento CA USA Center for Neuroscience University of California Davis Davis CA USA Department of Neurological Surgery University of California Davis Sacramento CA USA Department of Neurology University Of Colorado Denver School of Medicine Denver CO USA

Objective： This review examines the evidence that deep brain stimulation （DBS） has extensive impact on nonmotor symptoms （NMSs） of patients with Parkinson＇s disease （PD）. Data Sources： We retrieved information from the PubMed database up to September, 2015, using various search terms and their combinations including PD, NMSs, DBS, globus pallidus internus （GPi）, subthalamic nucleus （STN）, and ventral intermediate thalamic nucleus. Study Selection： We included data from peer-reviewed journals on impacts of DBS on neuropsychological profiles, sensory function, autonomic symptoms, weight changes, and sleep disturbances. For psychological symptoms and cognitive impairment, we tried to use more reliable proofs： Random, control, multicenter, large sample sizes, and long period follow-up clinical studies. We categorized the NMSs into four groups： those that would improve definitively following DBS; those that are not significantly affected by DBS; those that remain controversial on their surgical benefit; and those that can be worsened by DBS. Results： In general, it seems to be an overall beneficial effect of DBS on NMSs, such as sensory, sleep, gastrointestinal, sweating, cardiovascular, odor, urological symptoms, and sexual dysfunction, GPi-DBS may produce similar results; Both STN and Gpi-DBS are safe with regard to cognition and psychology over long-term follow-up, though verbal fluency decline is related to DBS： The impact of DBS on behavioral addictions and dysphagia is still uncertain. Conclusions： As the motor effects of STN-DBS and GPi-DBS are similar, NMSs may determine the target choice in surgery of future patients.

关键词： Deep Brain Stimulation Globus Pallidus lnternus nonmotor symptoms Parkinson's Disease Subthalamic Nucleus

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Meta-analyses on prevalence of selected Parkinson’s nonmotor symptoms before and after diagnosis

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Translational Neurodegeneration 2015年第1期4卷 1-8页

作者： Honglei Chen Edward J Zhao Wen Zhang Yi Lu Rui Liu Xuemei Huang Anna J Ciesielski-Jones Michele A Justice Deborah S Cousins Shyamal Peddada Epidemiology Branch National Institute of Environmental Health Sciences111 T.W.Alexander Dr.P.O.Box 12233Mail drop A3-05Research Triangle ParkNC 27709USA Social&Scientific Systems Inc.DurhamNorth CarolinaUSA Departments of Neurology RadiologyNeurosurgeryPharmacology&KinesiologyPennsylvania State University-Milton S.Hershey Medical CenterHersheyPennsylvaniaUSA Biostatistics Branch National Institute of Environmental Health SciencesResearch Triangle ParkNCUSA

Background:nonmotor symptoms are common among patients with Parkinson’s disease(PD)and some may precede disease ***:We conducted a meta-analysis on the prevalence of selected nonmotor symptoms before and after PD diagnosis,using random-effect *** searched PubMed(1965 through October/November 2012)for the following symptoms:hyposmia,constipation,rapid eye movement sleep behavior disorder,excessive daytime sleepiness,depression,and *** studies were publications in English with original data on one or more of these ***:The search generated 2,373 non-duplicated publications and 332 met the inclusion criteria,mostly(n=320)on symptoms after PD *** all symptoms,the prevalence was substantially higher in PD cases than in controls,each affecting over a third of the *** was the most prevalent(75.5%in cases vs.19.1%in controls),followed by constipation(50%vs.17.7%),anxiety(39.9%vs.19.1%),rapid eye movement sleep behavior disorder(37.0%vs.7.0%),depression(36.6%vs.14.9%),and excessive daytime sleepiness(33.9%vs.10.5%).We observed substantial heterogeneities across studies and meta-regression analyses suggested that several factors might have contributed to ***,the prevalence estimates were fairly robust in several sensitivity *** 20 studies had data on any symptoms prior to PD diagnosis,but still the analyses revealed higher prevalence in future PD cases than in ***:These symptoms are common among PD patients both before and after *** studies are needed to understand the natural history of nonmotor symptoms in PD and their etiological and clinical implications.

关键词： Parkinson’s disease nonmotor symptoms Meta-analysis Prevalence Natural history

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NADPH oxidase contributes to learning and memory deficits in a mouse model of Parkinson's disease

NADPH oxidase contributes to learning and memory deficits in...

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中国毒理学会第七次全国会员代表大会暨中国毒理学会第六次中青年学者科技论坛

作者： Fuqiang Sun Liyan Hou Yuning Che Lin Zhang Qingshan Wang School of Public Health Dalian Medical University Academy of Integrative Medicine Dalian Medical University

Background: Aside from classical motor deficits, Parkinson’s disease(PD) patients also experience various nonmotor symptoms, including cognitive deficits. We previously reported that the activation of NADPH oxidase contributes to dopaminergic neurodegeneration and motor deficits in PD. However, whetherNADPH oxidase is involved in non-motor symptoms, especially cognitive dysfunction in PD remains unknown. This study is undertaken to characterize the effects of inhibition of NADPH oxidase by a widely used NADPH oxidase inhibitor apocynin on learning and memory deficits in paraquat and maneb(P+M)-induced mouse PD ***: Three-month old mice were randomly divided into 4 groups, i.e. control, P+M,apocynin+P+M and apocynin alone groups. Mice in P+M group were administrated with combined paraquat(P, 10 mg/kg) and maneb(M, 30 mg/kg) for consecutive 6 weeks(twice per week).Mice in apocynin+P+M group were received with apocynin(1 mg/ml in drinking water) 2 days before P+M treatment. Learning and memory performance was measured by using Morris Water Maze test. Neuroinflammation, oxidative stress, and neuronal death in mice brains were measured by using immunohistochemistry, qPCR or Western blots ***: We found that mice injected with P+M displayed progressive impairments of spatial learning and memory, which was associated with reduced tyrosine hydroxylase expression as well as increased neurodegeneration, synaptic loss, α-synuclein expression and Ser129-phosphorylation in the hippocampus. Interestingly, apocynin treatment significantly ameliorated learning and memory deficits as well as hippocampal neurodegeneration and α-synuclein pathology in mice treated with these two pesticides. Mechanistically, we found that apocynin mitigated P+M-induced NADPH oxidase activation and related oxidative stress. Furthermore, reduced microglial activation and M1 polarization were observed in apocynin+P+M co-treated mice compared with P+M alone group. Finally, apocynin inhi

关键词： Parkinson’s disease nonmotor symptoms Cognitive deficits NADPH oxidase Neuroinflammation

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