检索结果-南通市图书馆

Lower clearance of sodium tanshinone IIA sulfonate in coronary heart disease patients and the effect of total bilirubin: a population pharmacokinetics analysis

引用

Chinese Journal of Natural Medicines 2019年第3期17卷 218-226页

作者： QIN Wei-Wei WANG Li JIAO Zheng WANG Bin WANG Cheng-Yu QIAN Li-Xuan QI Wei-Lin ZHONG Ming-Kang Department of Pharmacy Huashan Hospital Fudan University Department of Cardiology Huashan Hospital Fudan University

This study developed a population pharmacokinetic model for sodium tanshinone IIA sulfonate(STS) in healthy volunteers and coronary heart disease(CHD) patients in order to identify significant covariates for the pharmacokinetics of STS. Blood samples were obtained by intense sampling approach from 10 healthy volunteers and sparse sampling from 25 CHD patients, and a population pharmacokinetic analysis was performed by nonlinear mixed-effect modeling. The final model was evaluated by bootstrap and visual predictive check. A total of 230 plasma concentrations were included, 137 from healthy volunteers and 93 from CHD patients. It was a two-compartment model with first-order elimination. The typical value of the apparent clearance(CL) of STS in CHD patients with total bilirubin(TBIL) level of 10 μmol×L^(–1) was 48.7 L×h^(–1) with inter individual variability of 27.4%, whereas that in healthy volunteers with the same TBIL level was 63.1 L×h^(–1). Residual variability was described by a proportional error model and estimated at 5.2%. The CL of STS in CHD patients was lower than that in healthy volunteers and decreased when TBIL levels increased. The bootstrap and visual predictive check confirmed the stability and validity of the final model. These results suggested that STS dosage adjustment might be considered based on TBIL levels in CHD patients.

关键词： Sodium tanshinone IIA sulfonate nonlinear mixed-effects modeling Population pharmacokinetics Coronary heart disease Total bilirubin

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Population pharmacokinetics of tacrolimus in pediatric refractory nephrotic syndrome: comparison with other paediatric disease models

Population pharmacokinetics of tacrolimus in pediatric refra...

引用

第二十九届全国儿科药学学术年会暨第十届全国儿科药学中青年药师论文报告会

作者： DONGDONG WANG JINMIAO LU QIN LI ZHIPING LI Department of Pharmacy Children’s Hospital of Fudan University

Different population pharmacokinetics(PPK) of tacrolimus(TAC) models have been established in various pediatric disease populations. However, the TAC PPK model in pediatric refractory nephrotic syndro

关键词： pediatric refractory nephrotic syndrome nonlinear mixed-effects modeling population pharmacokinetics tacrolimus therapeutic drug monitoring

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：