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Current nondopaminergic Therapeutic options for Motor Symptoms of Parkinson＇s Disease

Chinese Medical Journal 2017年第15期130卷 1856-1866页

作者： Juan-Juan Du Sheng-Di Chen Department of Neurology and Institute of Neurology Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai 200025 China

Objective：The aim of this study was to summarize recent studies on nondopaminergic options for the treatment of motor symptoms in Parkinson＇s disease （PD）.Data Sources：Papers in English published in PubMed,Cochrane,and Ovid Nursing databases between January 1988 and November 2016 were searched using the following keywords：PD,nondopaminergic therapy,adenosine,glutamatergic,adrenergic,serotoninergic,histaminic,and iron *** also reviewed the ongoing clinical trials in the website of *** Selection：Articles related to the nondopaminergic treatment of motor symptoms in PD were selected for this ***：PD is conventionally treated with dopamine replacement strategies,which are effective in the early stages of ***-term use oflevodopa could result in motor *** studies revealed that nondopaminergic systems such as adenosine,glutamatergic,adrenergic,serotoninergic,histaminic,and iron chelator pathways could include potential therapeutic targets for motor symptoms,including motor fluctuations,levodopa-induced dyskinesia,and gait *** nondopaminergic drugs,such as istradefylline and amantadine,are currently used clinically,while most such drugs are in preclinical testing *** of these agents into clinically beneficial strategies requires reliable evaluation since several agents have failed to show consistent results despite positive findings at the preclinical ***：Targeting nondopaminergic transmission could improve some motor symptoms in PD,especially the discomfort *** nondopaminergic treatments show great potential in PD treatment as an adjunct therapy to levodopa,further investigation is required to ensure their success.

关键词： Dyskinesias Motor Fluctuations nondopaminergic options Parkinson Disease

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