检索结果-南通市图书馆

World Journal of Hepatology 2013年第11期5卷 621-626页

作者： Konstantinos Tziomalos Vasilios Giampatzis Stella D Bouziana Marianna Spanou Maria Papadopoulou Athinodoros Pavlidis Stavroula Kostaki Andreas Bozikas Christos Savopoulos Apostolos I Hatzitolios First Propedeutic Department of Internal Medicine Department of Medicine Aristotle University of Thessaloniki AHEPA Hospital

AIM:To evaluate the association of nonalcoholic fatty liver disease(NAFLD)with acute ischemic stroke severity and in-hospital outcome.METHODS:We prospectively studied all patients who were admitted in our Department with acute ischemic stroke between September 2010 and August 2012(n=415;39.5%males,mean age 78.8±6.6 years).The severity of stroke was assessed with the National Institutes of Health Stroke Scale(NIHSS)score at admission.NALFD was defined as serum alanine aminotransferase and/or aspartate aminotransferase levels above the upper limit of normal in the absence of other causes of elevated aminotransferases levels[chronic hepatitis B or C,drug toxicity,increased alcohol consumption(>21 and>14 drinks per week in men and women,respectively),cholestatic diseases or rhabdomyolysis].The outcome was assessed with the modified Rankin scale(mRS)score at discharge and in-hospital mortality.Adverse outcome was defined as mRS score at discharge≥2.Dependency at discharge was defined as mRS score between 2 to 5.RESULTS:NAFLD was present in 7.7%of the study population.Patients with NAFLD had lower serum high-density lipoprotein cholesterol and higher triglyceride levels than patients without NAFLD(P<0.05 for both comparisons).Demographic data,the prevalence of other cardiovascular risk factors and the prevalence of established CVD did not differ between the two groups.At admission,the NIHSS score did not differ between patients with and without NAFLD(6.3±6.4and 8.8±9.6,respectively;P=NS).At discharge,the mRS score did not differ between the two groups(1.9±2.2 and 2.6±2.2 in patients with and without NAFLD,respectively;P=NS).Rates of dependency at discharge were also similar in patients with and without NAFLD(36.8%and 55.0%,respectively;P=NS)as were the rates of adverse outcome(42.9%and58.6%,respectively;P=NS).In-hospital mortality rates also did not differ between the 2 groups(8.0%and 7.0%in patients with and without NAFLD,respectively;P=NS).CONCLUSION:The presence of NAFLD in patients admitted for acute ische

关键词： nonalcoholic fatty liver disease Stroke Outcome Aminotransferases γ-glutamyl transpeptidase Cardiovascular disease Type 2 diabetes mellitus Obesity Cardiovascular risk

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

绞股蓝皂苷对2型糖尿病合并非酒精性脂肪性肝病大鼠葡萄糖和脂质代谢的影响

引用

世界中西医结合杂志 2017年第3期12卷 337-341,352页

作者：贺琴李刚李芳李金科雷旭雷飞飞李儒贵谭华炳湖北医药学院附属人民医院肝病研究所湖北十堰442000 湖北医药学院附属人民医院药剂科湖北十堰442000

目的研究绞股蓝皂苷(gypenosides,GPS)对2型糖尿病并非酒精性脂肪性肝病(type2 diabetes mellitus and nonalcoholic fatty liver disease,T2DM-NAFLD)大鼠糖和血脂代谢的影响。方法60只SD大鼠被分为正常对照组(Ⅰ组,n=8)和T2DM-NAFLD模型组。Ⅰ组予普通饵料持续饲养;余大鼠通过高脂高糖饵料(HFSD)加小剂量链脲佐菌素注射经8周饲养建立T2DM-NAFLD模型。将T2DM-NAFLD模型大鼠分为模型组(Ⅱ组)、T2DM-NAFLD模型GPS小剂量干预组(Ⅲ组)、T2DM-NAFLD模型GPS中剂量干预组(Ⅳ组)、T2DM-NAFLD模型GPS大剂量干预组(Ⅴ组);继续HFSD饲养;Ⅲ组、Ⅳ组、Ⅴ组分别予GPS 200、400、800 mg/(kg·d)干预,时间6周;实验周期14周。检测血天门冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)、血糖(BS),甘油三酯(TG)、总胆固醇(TC)。进行大鼠口服葡萄糖耐量(OGTT)实验。观察肝脏病理学变化。结果 (1)ALT、AST水平:与Ⅱ组比较,Ⅲ组、Ⅳ组、Ⅴ组显著降低AST、ALT水平(P<0.05,P<0.01),呈剂量依赖性。(2)TG、TC水平:与Ⅱ组比较,Ⅲ组、Ⅳ组、Ⅴ组显著降低TG,TC水平(P<0.05,P<0.01),呈剂量依赖性。(3)BS水平和OGTT曲线:与Ⅱ组比较,Ⅲ组、Ⅳ组、Ⅴ组显著降低BS(P<0.01),呈剂量依赖性;与Ⅱ组比较,Ⅲ组、Ⅳ组、Ⅴ组显著改善OGTT曲线。(4)血胰岛素水平:与Ⅱ组比较,Ⅲ组、Ⅳ组、Ⅴ组显著降低血胰岛素水平(P<0.01),呈剂量依赖性。⑸肝脏病理学:干预组能减轻治疗组大鼠肝脏脂肪浸润程度,呈剂量依赖性。结论 GPS对T2DM-NAFLD大鼠糖代谢和脂质代谢异常具有调整作用,呈剂量依赖性。

关键词：绞股蓝皂苷(gypenosides,GPS) 2型糖尿病非酒精性脂肪性肝病(type 2 diabetesmellitus and nonalcoholic fatty liver disease,T2DM-NAFLD) 血糖(BS) 甘油三酯(TG)

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

不含酒精的脂肪肝疾病和高血压蛋白原酶血管收缩素系统: 为治疗的含意

引用

World Journal of Hepatology 2012年第12期4卷 327-331页

作者： Paschalis Paschos Konstantinos Tziomalos First Propedeutic Department of Internal Medicine Medical SchoolAristotle University of ThessalonikiAHEPA Hospital54636 ThessalonikiGreece

nonalcoholic fatty liver disease(NAFLD) is the commonest liver disease in Western countries.Treatment of NAFLD is currently based on lifestyle measures and no effective pharmacologic treatment is available so far.Emerging evidence,mainly from animal studies,suggests that the renin-angiotensin-aldosterone system may be of major importance in the pathogenesis of NAFLD and indicates that angiotensin-converting enzyme inhibitors(ACE-I) and angiotensin receptor blockers(ARBs) as a potentially useful therapeutic approach.However,data from human studies are limited and contradictory.In addition,there are few randomized controlled trials(RCTs) on the effects of ACE-I or ARB in patients with NAFLD and most data are from retrospective studies,pilot prospective studies and post hoc analyses of clinical trials.Accordingly,more and larger RCTs are needed to directly assess the effectiveness of ACE-I and ARBs in NAFLD.

关键词： nonalcoholic fatty liver disease Non alcoholic steatohepatitis Renin-angiotensin-aldosterone system Angiotensin-converting enzyme inhibitors An-giotensin receptor blockers Fibrosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

不含酒精的脂肪肝疾病是新陈代谢的症候群的肝的表示吗？

引用

World Journal of Hepatology 2012年第12期4卷 332-334页

作者： Yusuf Yilmaz Department of Gastroenterology School of MedicineMarmara University34840 IstanbulTurkey Institute of Gastroenterology Marmara University34840 IstanbulTurkey

nonalcoholic fatty liver disease(NAFLD) is generally considered as the hepatic manifestation of the metabolic syndrome(MS).Although there is no doubt that NAFLD is tightly linked to the MS,the diagnosis of NAFLD encompasses a broad range of histological entities and as a composite phenotype may be hindering attempts to understand the mechanistic basis of these variants.The awareness that NAFLD is not solely and invariably associated with the MS is a useful means to help direct future studies.We should be aware that mechanisms other than insulin resistance may contribute to the chronic inflammatory processes that underpin the development of liver fat accumulation and the subsequent architectural distortion of the liver.Further studies with special focus on hemoglobin as a risk factor for the development of NAFLD in the absence of MS should be performed.

关键词： nonalcoholic fatty liver disease Metabolic syndrome Insulin resistance Fibrosis Hemoglobin

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：