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Outcomes of patients with pelvic leiomyosarcoma treated by surgery and relevant auxiliary diagnosis

World Journal of Clinical Cases 2020年第10期8卷 1887-1896页

作者： Qian Sun Xin Yang Zhen Zeng Xiao Wei Ke-Zhen Li Xiao-Yan Xu Department of Obstetrics and Gynaecology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030Hubei ProvinceChina

BACKGROUND leiomyosarcoma is a subtype of soft tissue sarcoma with adverse *** accounts for nearly 70%of all uterine sarcomas and is responsible for a considerable proportion of deaths because of uterine *** characteristics and relevant diagnosis of pelvic leiomyosarcoma should be further *** To identify the outcome and relevant perioperative evaluation of patients with pelvic *** The Kaplan-Meier method was used to determine progression-free survival and overall survival *** predictive of outcomes were identified using univariate and multivariate Cox proportional hazards *** Fifty-one patients with pelvic leiomyosarcoma were enrolled and divided into two groups including uterine leiomyosarcoma and non-uterine ***,28.6%and 45.5%of uterine leiomyosarcoma and non-uterine leiomyosarcoma patients,respectively,had elevated carbohydrate antigen 125 levels,whereas 45.7%and 68.8%,respectively,underwent *** 68.8%of uterine leiomyosarcoma patients were initially diagnosed with hysteromyoma,72.7%of non-uterine leiomyosarcoma patients had pelvic and abdominal ***,93.3%of the recurrent lesions were detected using *** with International Federation of Gynaecology and Obstetrics(FIGO)stages III–IV disease had poorer progression-free survival values than those with FIGO stages I–II(P=0.027)*** stage was significantly associated with poor progression-free survival in the univariate(hazard ratio=2.64,P=0.03)and multivariate(hazard ratio=2.49,P=0.048)*** Serum tumour biomarkers cannot be used for pelvic leiomyosarcoma *** stage is critical to predict the outcome of uterine *** is more reliable for postoperative follow-up than preoperative diagnosis.

关键词： uterine leiomyosarcoma non-uterine leiomyosarcoma Serum biomarker Prognosis Ultrasonography

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