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Prevalence of non-tuberculosis mycobacteria among samples deposited from the National Tuberculous Reference Laboratory of Iran(2011-2018)

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Asian Pacific Journal of Tropical Medicine 2021年第10期14卷 451-456页

作者： Saman Ayoubi Parissa Farnia Poopak Farnia Jafar Aghajani Jalaledin Ghanavi Ali Akbar Velayati Mycobacteriology Research Center(MRC) National Research Institute of Tuberculosis and Lung Disease(NRITLD)Shahid Beheshti University of Medical SciencesTehranIran Department of Biotechnology School of Advanced Technology in MedicineShahid Beheshti University of Medical SciencesTehranIran

Objective:To investigate the prevalence of non-tuberculosis mycobacteria(NTM)among the samples deposited from the National tuberculosis Reference Laboratory of Iran between 2011 and ***:The study evaluated the prevalence of NTM among specimens from patients with pulmonary tuberculosis symptoms(n=15771)deposited at the National tuberculosis Reference Laboratory of Iran from 2011 to *** of mycobacterium(M.)tuberculosis was based on presence of a 190-bp amplicon from IS6110 insertion sequence using Tb1 and Tb2 primers,and amplicon-negative specimens were tested for NTM and ***(refractory to IS6110 amplification)using restriction fragment length polymorphism PCR of hsp65 amplicon ***:A total of 7307(46.33%)*** and 658(4.17%)NTM specimens were found,the latter mainly comprising ***(10.18%),***(2.28%),***(8.97%),***(10.49%),***(4.71%),and ***(56.08%).Conclusions:As treatment for NTM differs from that for ***,accurate detection of mycobacterium *** of public health significance.

关键词： Diagnosis Iran non-tuberculosis mycobacterium Prevalence

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Pathological humerus fracture due to anti-interferon-gamma autoantibodies:A case report

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World Journal of Orthopedics 2021年第11期12卷 938-944页

作者： Cheng Hsun Yang Feng-Chih Kuo Chen-Hsiang Lee Division of Infection Disease Department of Internal MedicineKaohsiung Chang Gung Memorial HospitalKaohsiung 833Taiwan Department of Orthopaedic Surgery Kaohsiung Chang Gung Memorial HospitalKaohsiung 833Taiwan Division of Infection Disease Department Internal MedicineChang Gung UniversityCollege MedicineChang Gung Memorial HospitalKaohsiung Medicine CentreKaohsiung 833Taiwan

BACKGROUND Various etiologies contribute to pathological fractures,including bone ***,non-tuberculosis mycobacterium-related bone infections among patients with anti-interferon-gamma autoantibody-induced adult-onset immunodeficiency has raised concerns in Southeast Asia,with the common presentations including ***,it also rarely manifests as traumatic fractures,as reported in this *** SUMMARY A diabetic female fractured her humerus after a traumatic accident and received fixation *** necrotic bone tissue and abscess formation were noted,and she was diagnosed with a pathological fracture due to nontuberculosis mycobacterium *** bone involvement was also revealed in a bone ***-interferon-gamma autoantibodies were then checked due to an unexplained immunocompromised status and found to be *** humerus fracture and multiple bone infections healed after steroid and anti-non-tuberculosis mycobacterium medication treatment following fixation *** Comprehensive preoperative evaluations may help identify pathological fractures and guide the treatment course.

关键词： Immunocompromised status Neutralizing anti-interferon-gamma autoantibody non-tuberculosis mycobacterium Pathological fracture Pre-operative evaluations Case report

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Genitourinary Bacillus Calmette-Guerin Infection after BCG Intravesical Administration in a Patient under Hemodialysis—What Can We Do Better?

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Advances in Infectious Diseases 2022年第3期12卷 563-567页

作者： Lúcia Ribeiro Dias Catarina Almeida Fernando Nogueira Rita Soares Sofia Garcês Soares Maria Lima Costa Maria Teresa Boncoraglio Filipa Ceia Infectious Diseases Department University Hospital Center of S&#227 o Joã o Porto Portugal Internal Medicine Department Hospital Center of Tondela-Viseu Viseu Portugal Internal Medicine Department University Hospital Center of S&#227 o Joã o Porto Portugal Internal Medicine Department Tamega e Sousa Hospital Center Penafiel Portugal

A 74-year-old man with terminal chronic kidney disease, under hemodialysis and with residual diuresis, was admitted due to myalgia, arthralgia, fever and pyuria in the previous 10 days. The patient had a recent diagnosis of high-grade non-invasive bladder cancer and was doing weekly BCG intravesical administrations. The symptoms started three days before the fifth administration. He had done cefixime as an outpatient and started piperacillin-tazobactam on hospital admission, but the fever persisted, and there was no bacterial isolation in urine or blood culture. On the tenth and seventeenth day after the last BCG intravesical administration mycobacterium bovis was still isolated in the urine culture. The diagnosis of BCGitis was made and treatment was started, with a good response. Forty days after the last administration and under treatment, the culture remained positive for mycobacterium bovis in the urine. We raise the question about the safety of BCG administration in patients with residual diuresis.

关键词： BCGitis mycobacterium Bovis Hemodialysis non-tuberculosis mycobacterium Bladder Cancer

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