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Quantitative multiparametric magnetic resonance imaging can aid non-alcoholic steatohepatitis diagnosis in a Japanese cohort

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World Journal of Gastroenterology 2021年第7期27卷 609-623页

作者： Kento Imajo Louise Tetlow Andrea Dennis Elizabeth Shumbayawonda Sofia Mouchti Timothy J Kendall Eve Fryer Shogi Yamanaka Yasushi Honda Takaomi Kessoku Yuji Ogawa Masato Yoneda Satoru Saito Catherine Kelly Matt D Kelly Rajarshi Banerjee Atsushi Nakajima Department of Gastroenterology and Hepatology Yokohama City University School of MedicineYokohama 236-0004Japan Innovation PerspectumOxford OX42LLUnited Kingdom Centre for Inflammation Research University of EdinburghEdinburghUnited KingdomEdinburgh EH164TJUnited Kingdom Department of Cellular Pathology Oxford University Hospitals NHS Foundation TrustOxford OX39DUUnited Kingdom Anatomic and Clinical Pathology Department Yokohoma City University HospitalYokohoma 236-0004Japan Department of Gastroenterology Yokohama City University Graduate School of MedicineYokohama 236-0004Japan

BACKGROUND non-invasive assessment of non-alcoholic steatohepatitis(NASH)is increasing in desirability due to the invasive nature and costs associated with the current form of assessment;liver *** multiparametric magnetic resonance imaging(mpMRI)to measure liver fat(proton density fat fraction)and fibroinflammatory disease[iron-corrected T1(cT1)],as well as elastography techniques[vibration-controlled transient elastography(VCTE)liver stiffness measure],magnetic resonance elastography(MRE)and 2D Shear-Wave elastography(SWE)to measure stiffness and fat(controlled attenuated parameter,CAP)are emerging alternatives which could be utilised as safe surrogates to liver *** To evaluate the agreement of non-invasive imaging modalities with liver biopsy,and their subsequent diagnostic accuracy for identifying NASH *** From January 2019 to February 2020,Japanese patients suspected of NASH were recruited onto a prospective,observational study and were screened using noninvasive imaging techniques;mpMRI with LiverMultiScan®,VCTE,MRE and *** were subsequently biopsied,and samples were scored by three independent *** diagnostic performances of the non-invasive imaging modalities were assessed using area under receiver operating characteristic curve(AUC)with the median of the histology scores as the gold standard *** between all three independent pathologists was further explored using Krippendorff’s alpha(a)from weighted kappa *** N=145 patients with mean age of 60(SD:13 years.),39%females,and 40%with body mass index≥30 kg/m2 were included in the *** identifying patients with NASH,MR liver fat and cT1 were the strongest performing individual measures(AUC:0.80 and 0.75 respectively),and the mpMRI metrics combined(cT1 and MR liver fat)were the overall best non-invasive test(AUC:0.83).For identifying fibrosis≥1,MRE performed best(AUC:0.97),compared to VCTE-liver stiffness measure(AU

关键词： Corrected T1 Fibro-inflammation non-invasive imaging non-alcoholic steatohepatitis Multiparametric magnetic resonance imaging non-alcoholic fatty liver disease

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non-invasive in vivo diagnosis of brain glioma using RGD decorated fluorescent carbonaceous nanospheres

Non-invasive in vivo diagnosis of brain glioma using RGD dec...

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2014年中国药学大会暨中国药师周

作者： Shaobo Ruan Qin He Huile Gao Key Laboratory of Drug Targeting and Drug Delivery Systems West China School of PharmacySichuan University

Carbon nanomaterials,including graphene,carbon nanotubes,fullerene and fluorescent carbonaceous nanospheres（CDs）,have been extensively applied in many *** which,CDs have generated much excitement because of their unique optical and electronic properties,such as low photobleaching,no optical blinking,size-and composition-tunable fluorescence emission from visible to infrared wavelengths,large absorption coefficients across a broad spectral range and high levels of brightness and *** obtain CDs with high-quality,many methods were introduced and developed,including thermal/hydrothermal oxidation,electrochemical synthesis and microwave/ultrasonic synthesis[8].One-step hydrothermal/thermal treatment methods have been widely used for preparing CDs from various carbon materials,such as silk,juice,glucose or other synthetic ***,CDs have been explored in its various promising applications especially in biology and *** application of CDs has approached bio-imaging in tumor cells and tumor tissue,which was contributed to the photoluminescent characteristic of CDs and pathological property of *** to the quick amplification of tumor cells,there is a leaky vasculature in subcutaneous tumor with pore size of approximately 200 nm to 1.2μm,which was well-known as enhancedpermeability and retention *** CDs could passively target to these tumors by EPR effect which was benefited from their small particle ***,their application in non-invasive imaging of diseased tissues was restricted by the poor targeting efficiency of CDs due to the existence of biological barriers in *** glioma,the most aggressive and common intracranial tumor,is considered as the major cause of death from central nervous system *** blood brain barrier（BBB）restricts the transportation from blood vessels to brain,BBB is compromised in the glioma because of the quick growth of ***,the cutoff pore size of glioma is muc

关键词： fluorescent carbonaceous nanospheres RGD glioma non-invasive imaging

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