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Validation of conventional non-invasive fibrosis scoring systems in patients with metabolic associated fatty liver disease

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World Journal of Gastroenterology 2021年第34期27卷 5753-5763页

作者： Yin-Lian Wu Rahul Kumar Ming-Fang Wang Medha Singh Jiao-Feng Huang Yue-Yong Zhu Su Lin Department of Hepatology Hepatology Research InstituteThe First Affiliated HospitalFujian Medical UniversityFuzhou 350005Fujian ProvinceChina Department of Gastroenterology and Hepatology Duke-NUS academic Medical CentreChangi General HospitalSingapore 529889Singapore Department of General Medicine Tan Tock Seng HospitalSingapore 308433Singapore

BACKGROUND non-invasive fibrosis scores are not yet validated in the newly defined metabolic associated fatty liver disease(MAFLD).AIM To evaluate the diagnostic performance of four non-invasive scores including aspartate aminotransferase to platelet ratio index(APRI),fibrosis-4 index(FIB-4),body mass index,aspartate aminotransferase/alanine aminotransferase ratio,diabetes score(BARD),and nonalcoholic fatty liver disease fibrosis score(NFS)in patients with *** Consecutive patients with histologically confirmed MAFLD were *** discrimination ability of different non-invasive scores was *** A total of 417 patients were included;156(37.4%)of them had advanced fibrosis(Metavir≥F3).The area under receiver operating characteristic curve of FIB-4,NFS,APRI,and BARD for predicting advanced fibrosis was 0.736,0.724,0.671,and 0.609,*** area under receiver operating characteristic curve of FIB-4 and NFS was similar(P=0.523),while the difference between FIB-4 and APRI(P=0.001)and FIB-4 and BARD(Pfibrosis in MAFLD were 1.05,-2.1,0.42,and 2.A subgroup analysis showed that FIB-4,APRI,and NFS performed worse in the pure MAFLD group than in the hepatitis B virus-MAFLD *** APRI and BARD scores do not perform well in *** FIB-4 and NFS could be more useful,but a new threshold is *** non-invasive scoring systems for fibrosis are required for MAFLD.

关键词： Metabolic associated fatty liver disease non-invasive fibrosis scores fibrosis-4 index non-alcoholic fatty liver disease fibrosis score Aspartate aminotransferase to platelet ratio index BARD

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