检索结果-南通市图书馆

Prognostic non-invasive biomarkers for all-cause mortality in nonalcoholic fatty liver disease:A systematic review and meta-analysis

引用

World Journal of Hepatology 2022年第5期14卷 1025-1037页

作者： Nicole Cianci Mohsan Subhani Trevor Hill Amardeep Khanna Dong Zheng Abhishek Sheth Colin Crooks Guruprasad P Aithal NIHR Oxford Biomedical Research Centre Oxford University Hospitals NHS Foundation Trust and University of OxfordOxford OX39DUUnited Kingdom Nottingham Digestive Diseases NIHR Biomedical Research Centre and the University of Nottingham Nottingham NG72UHUnited Kingdom King’s Liver Transplant Unit King's College HospitalLondon SE59RSUnited Kingdom NIHR Biomedical Research Center Freeman Hospital and Newcastle UniversityNewcastle upon Tyne NE77DNUnited Kingdom Liver Unit Queen Elizabeth Hospital BirminghamBirmingham B152GWUnited Kingdom School of Medicine Queen Mary University LondonLondon E14NSUnited Kingdom

BACKGROUND non-alcoholic fatty liver disease(NAFLD)represents a growing public health concern,with patients having higher risk of morbidity and *** has a considerably high prevalence in the general population,estimated 20%-40%in Europe,and is asymptomatic until late in the disease *** is therefore important to identify and validate tools that predict hard outcomes such as mortality for use in clinical practice in risk-stratifying NAFLD *** To evaluate available evidence on the use of non-invasive test(s)as prognostic factors for mortality in *** We performed electronic searches of Medline and EMBASE(Ovid)until 7^(th)January 2021 of studies in NAFLD *** markers included serum biomarkers,non-invasive scoring systems,and non-invasive *** population included all spectrums of disease severity,including NAFLD and non-alcoholic steatohepatitis(NASH).Outcomes included all-cause,and cardiovascular *** non-invasive tests were synthesised in a narrative systematic ***,we conducted a meta-analysis of non-invasive scoring systems for predicting all-cause and cardiovascular mortality,calculating pooled hazard ratios and 95%confidence(STATA 16.1).RESULTS Database searches identified 2850 studies-24 were included.16 studies reported non-invasive scoring systems,10 studies reported individual biomarkers,and 1 study reported imaging modalities.4 studies on non-invasive scoring systems(6324 participants)had data available for inclusion in the *** non-invasive scoring system that performed best at predicting all-cause mortality was NAFLD fibrosis score(NFS)[pHR 3.07(1.62-5.83)],followed by fibrosis-4 index[pHR 3.06(1.54-6.07)],BARD[pHR 2.87(1.27-6.46)],and AST to platelet ratio index[pHR 1.90(1.32-2.73)].NFS was also prognostic of cardiovascular-related mortality[pHR 3.09(1.78-5.34)].CONCLUSION This study reaffirms that non-invasive scoring systems,especially NFS,are reliable prognostic mark

关键词： nonalcoholic fatty liver disease nonalcoholic steatohepatitis Biomarkers non-invasive Prognosis Mortality

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

non-invasive detection of pancreatic cancer by measuring DNA methylation of Basonuclin 1 and Septin 9 in plasma

引用

Chinese Medical Journal 2019年第12期132卷 1504-1506页

作者： Xiao-Bin Li Jun Ma Zi-Wen Liu Wen-Fei He Zong-Ze Li Ming Cui Huang Hao Guang-Peng Zhou Lei You James Wang Xiao-Liang Han Yu-Pei Zhao Department of General Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences & Peking Union Medical CollegeBeijing 100730China BioChain (Beijing) Science & Technology Inc. Beijing 102600China

Pancreatic cancer (PC), a deadly malignancy with an overall 5-year survival rate of 5% to 15%, is ranked as the seventh leading cause of cancer death in the world in spite of its low occurrence rate.[1,2] Early detection appears to be the most effective approach to improve the overall survival of patients with PC. However, the difficulty in early detection of PC is a lack of specific symptoms and reliable biomarkers. Currently, carbohydrate antigen 19-9 (CA 19-9) is a serum biomarker that is widely used in PC detection. However, 10% of patients with PC cannot produce CA 19-9 and serum CA 19-9 is frequently absent in patients with early-stage cancer. Furthermore, CA 19-9 is often found to be elevated in benign conditions or in other cancers, making its utility limited. Therefore, it is important to identify new diagnostic biomarkers to improve PC detection.

关键词： non-invasive detection pancreatic cancer measuring DNA methylation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

non-invasive foetal heartbeat rate extraction from an underdetermined single signal

引用

Health 2009年第2期1卷 111-116页

作者： Ranjan Acharyya Neil L Scott Paul D Teal Industrial Research Ltd Victoria University of Wellington

Extraction of foetal heartbeat rate from a single passive sound sensor on the mother’s abdomen is demonstrated. The extraction is based on the assumption that a disjoint band of frequencies exist and foetal signal is concentrated in this band, and further that it can be represented conveniently as a set of wavelet coefficients. The algorithm has been applied to each stream of data obtained from six different channels and the detection performance is elaborated. The algorithm has also been tested on signals from non-pregnant abdomens to show successful rejection of adult heartbeat. The extraction of the desired signal is done in two stages so as to eliminate components from the maternal heart-beat.

关键词： Underdetermined System Foetal Heartbeat Rate Wavelet Blind Source Separation non-invasive Passive.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

non-invasive focused ultrasound for abdominal circumference reduction:does it really work?

引用

Plastic and Aesthetic Research 2016年第1期3卷 368-374页

作者： Eric Barel Abraham Amir Asaf Olshinka Dean Ad-El Department of Plastic and Reconstructive Surgery Rabin Medical CenterBeilinson Hospital(affiliated with Sackler Faculty of MedicineTel Aviv University)Petach Tikva 49100Israel Post-Barriatric Plastic Surgery Clinic Rabin Medical CenterBeilinson Hospital(affiliated with Sackler Faculty of MedicineTel Aviv University)Petach Tikva 49100Israel.

Aim:non-invasive body contouring is a promising ***,due to a lack of good evidence-based data,the mechanism by which contouring occurs remains *** purpose of this study was to evaluate the effect of treatment with the Contour I™ultrasound system(Ultrashape®,Syneron®,Israel)on abdominal circumference and to compare 2 power levels for efficacy and ***:A prospective,self-controlled double-blind design was ***-six women,aged 30-45 years,were randomized to receive treatment with the Contour I at high or low acoustic outputs in 3 successive sessions,1 month *** was evaluated by adverse events,local skin reaction,and *** was evaluated by the change in abdominal circumference relative to baseline and to the untreated thigh area(internal control).Patients were followed for 28 days after the last treatment ***:At 1 month after the first session,the mean reductions in abdominal circumference measured 1.65 cm(P<0.001)and 0.87 cm(P<0.019)in the high and low-power groups,*** 1 month after the last session,the cumulative reductions in circumference were 2.56 cm(P<0.001)and 1.49 cm(P<0.012),*** was no change in the internal-control circumference throughout *** were no treatment-induced severe adverse ***:Multiple successive treatments of the abdominal area with the Contour I lead to a significant progressive reduction in *** magnitude of the reduction is directly correlated to the acoustic power output which suggests that the technology itself is the main cause for the contouring effect.

关键词： Body contouring ultrasound fat cell disruption liposuction non-invasive

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

non-invasive splenic parameters of portal hypertension:Assessment and utility

引用

World Journal of Hepatology 2020年第11期12卷 1055-1066页

作者： Ayesha Karim Ahmad Sebastiana Atzori James Maurice Simon D Taylor-Robinson Adrian KP Lim Liver Unit Department of DigestionMetabolism&ReproductionFaculty of MedicineImperial College LondonLondon W21NYUnited Kingdom Liver Unit Department of DigestionMetabolism&ReproductionImperial College LondonLondon W21NYUnited Kingdom Liver Unit and Imaging Department of DigestionMetabolism&ReproductionImperial College LondonLondon W21NYUnited Kingdom

BACKGROUND Portal hypertension is a major complication of cirrhosis that is associated with significant morbidity and *** present gold-standard method to risk stratify and observe cirrhosis patients with portal hypertension is hepatic venous pressure gradient measurement or ***,these methods are invasive,carry a risk of complications and are associated with significant patient ***,non-invasive splenic parameters are of clinical interest as potential useful markers in determining the presence of portal ***,diagnostic accuracy and reproducibility remains *** To assess the diagnostic accuracy of spleen stiffness,area and diameter in predicting the presence of portal *** Of 50 patients with varying liver disease pathologies were prospectively recruited from the ***’s Hospital Liver Unit in London;25 with evidence of portal hypertension and 25 with no evidence of portal *** stiffness,spleen stiffness,spleen diameter and spleen area were measured using the Philips Affiniti 70 elastography point quantification point shear wave elastography *** aspartate aminotransferase-to-platelet-ratio-index(APRI)score was also *** measures,univariate and multivariate logistic regression were used to evaluate demographic,clinical and elastography *** correlation coefficient was used to determine the reproducibility of splenic area and *** On univariate and individual performance,platelet count[area under the receiver operating characteristic(AUROC)0.846,P value<0.001],spleen area(AUROC 0.828,P value=0.002)and APRI score(AUROC 0.827,P value<0.001)were the most accurate variables in identifying the presence of portal *** multivariate logistic regression models constructed,the combination of spleen area greater than 57.90 cm2 and platelet count less than 126×10^9 had 63.2%sensitivity and 100%specificity

关键词： Portal hypertension Esophageal varices Point shear wave elastography Spleen stiffness Spleen area non-invasive

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

non-invasive Evaluation and Differential Diagnosis for Pediatric Leukoderma in a Single Institute

引用

Journal of Cosmetics, Dermatological Sciences and Applications 2019年第4期9卷 313-320页

作者： Madoka Takafuji Atsushi Tanemura Yuma Hanaoka Noriko Arase Eiji Kiyohara Ichiro Katayama Manabu Fujimoto Department of Dermatology Osaka University Graduate School of Medicine Suita Japan

Background: Although vitiligo shows a similar clinical picture to other disorders in which patients exhibit depigmented spots, there are few reports on the differentiation of these conditions from each other. Purpose: We aimed to investigate the differences and similarities between vitiligo and nevus depigmentosus in children based on the clinical course and characteristics. Materials and Methods: We conducted an examination of the disease type, treatment, progress, and differentiation of 85 cases of vitiligo and nevus depigmentosus that developed before 15 years of age among patients who visited the Osaka University Department of Dermatology with a chief complaint of white patches from January 2010 to March 2017. Results: The median age at the onset of symptoms of 79 patients with vitiligo was 4.5 years and while that of 6 patients with nevus depigmentosus was 0.8 years, indicating that the onset of nevus depigmentosus occurred earlier. While vitiligo often developed in the head and neck regions, with a tendency for depigmented spots in multiple regions, nevus depigmentosus did not show this tendency in these regions. Upon performing Wood’s lamp observation in 38 cases of vitiligo, 35 cases were found to be fluorescent chalky white and in 3 cases histologically diagnosed as vitiligo, no clear fluorescent color was observed. All 6 patients diagnosed with nevus depigmentosus exhibited a non-fluorescent off-white color under a Wood’s lamp. Conclusions: This study indicates that non-invasive observation using a Wood’s lamp is useful in the differential diagnosis of pediatric leukoderma, in addition to the subsequent clinical course, such as the presence or absence of lesional repigmentation and/or enlargement.

关键词： Pediatric Leukoderma Vitiligo Nevus Depigmentosus non-invasive Diagnosis Wood’s Lamp

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

non-invasive Approaches for Oral Potential Malignant Disorders Surveillance: A Review

引用

Advances in Bioscience and Biotechnology 2020年第5期11卷 188-205页

作者： Jiaying Zhou Quan Liu Xianyue Ren Bin Cheng Tong Wu Department of Oral Medicine Affiliated Hospital of Stomatology Guanghua School of Stomatology Sun Yat-sen University Guangzhou China Guangdong Provincial Key Laboratory of Stomatology Guanghua School of Stomatology Sun Yat-sen University Guangzhou China Zhujiang New Town Dental Clinic Affiliated Hospital of Stomatology Guanghua School of Stomatology Sun Yat-sen University Guangzhou China.

Oral potential malignant disorders (OPMDs), a series of local diseases with carcinogenic potential occurred in oral mucosa, have the possibility of developing into oral cancer. Effective diagnosis and surveillance at the early stage of OPMDs may be of help for interrupting the malignant transformation. In this review, we introduced the available non-invasive approaches of detecting the suspicious lesions, including vital staining, oral cytology, optical detection, saliva biomarkers detection, and image analysis, which can enhance the detection efficiency for the early diagnosis and surveillance of OPMDs. However, limitations which restrict the clinical application of these approaches still exist. How to improve the sensitivity and specificity of these techniques deserves further detailed study.

关键词： Oral Potential Malignant Disorders non-invasive Detection Approaches Malignant Transformation Early Diagnosis Surveillance

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

non-invasive Cosmetic Beauty Procedures Become Fashionable

引用

China's Foreign Trade 2019年第6期 56-58页

作者： Lynn Yu 不详

In recent years,Chinese consumers have gradually awakened their awareness of"non-invasive cosmetic beauty procedures".The concept of non-invasive cosmetic beauty procedures first emerged in 2014 in the European medical beauty field,and gradually became popular in China *** medical beauty is a professional medical cosmetology program between plastic surgery and cosmetology,which refers to meet the demand for beauty via the use of non-invasive or minimally invasive medical treatment with advanced products,instruments and medical means.

关键词： non-invasive Cosmetic Become Fashionable Media

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A Retrospective Analysis of Three non-invasive Tests for Initial Diagnosis of <i>Helicobacter pylori</i>Infection in Children

引用

Advances in Microbiology 2017年第4期7卷 253-264页

作者： Tamaki Ikuse Takahiro Kudo Naho Obayashi Keisuke Jimbo Yo Aoyagi Yoshikazu Ohtsuka Thomas G. Blanchard Steven J. Czinn Toshiaki Shimizu Department of Pediatric and Adolescent Medicine Juntendo University Graduate School of Medicine Tokyo Japan Department of Pediatrics University of Maryland School of Medicine Baltimore USA

Proper diagnosis in the pediatric population is required to eradicate Helicobacter pylori (H. pylori) and prevent gastric cancer. Our aim was to assess the performance of non-invasive tests to diagnose H. pylori infection in pediatric patients. A retrospective analysis was performed on 141 pediatric patients requiring endoscopic evaluation and diagnostic tests for H. pylori infection to define the cause of abdominal symptoms. non-invasive tests included the 13C-urea breath test (UBT), a monoclonal stool antigen test using enzyme-linked immuno-sorbent assay (mSAT), and a serum immunoglobulin G antibody test using antigens derived from Japanese individuals (S-Ab). This study investigated sensitivity, specificity, likelihood ratios for a positive and a negative test (LR+ and LR-), and accuracy of non-invasive tests, in comparison with invasive tests. Eighty two of 141 patients (58%) were recognized as H. pylori positive by invasive methods. When UBT, mSAT or S-Ab were analyzed, all were found to be effective over 94% accurate. Specificity ranged between 86.7% and 95.8%, and sensitivity ranged between 93.8% and 97.1%. When subjects were stratified into three distinct age groups, the best performance was achieved for 1-6 years old with mSAT at 100% for sensitivity, specificity, and accuracy. S-Ab yielded the best results for children 7-12 years old and the UBT test performed best for 13-18 years old. These results demonstrate the utility of UBT, mSAT, and S-Ab non-invasive tests in diagnosing H. pylori but suggest that certain tests may be optimal for children of distinct ages. Three non-invasive tests, UBT, mSAT and S-Ab showed sufficient sensitivity, specificity and accuracy for the initial diagnosis of H. pylori infection among pediatric patients. non-invasive tests may contribute to achieving minimum invasive diagnosis with combining with a histological test and a culture test in children.

关键词： Accuracy non-invasive Tests Urea Breath Test Stool Antigen Test Serum Antibody Test

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Photo Acoustic Energy Applications for the Detection of Human Arterial Blockages via Multiple Skin/Bone Layers, a non-invasive Approach

引用

World Journal of Cardiovascular Diseases 2017年第8期7卷 251-270页

作者： Monika Kakani Neeraj Rathi Ahdy Helmy Ashok Kumar Thella M. D. James Rizkalla Paul Salama Maher E. Rizkalla Department of Electrical and Computer Engineering Indiana University Purdue University Indianapolis (IUPUI) Indianapolis USA VA Hospital Indiana University School of Medicine Indianapolis USA Baylor University Medical Center (BUMC) Dallas USA Integrated Nanosystems Development Institute IUPUI Indianapolis USA Richard G. Lugar Center for Renewable Energy IUPUI Indianapolis USA

The impact of arterial narrowing/blocking caused by plaque buildup in arteries leads to many life-threatening consequences. This is recognized as a cause in heart attacks and peripheral vascular disease. Diagnosing the illness is only feasible after symptoms have presented to the patient. Currently, the standard for visualizing coronary arteries is through angiography, which may have complications, and impact on the healthcare system. Furthermore, cardiac catheterization may also places high health risks, given its overall invasiveness. Cardiac arrhythmias, infection, and contrast dye nephrotoxicity are recognized complications within this process. Therefore, a noninvasive approach may have potentials to reduce patient complications, finances surrounding healthcare, and more efficient patient care through earlier screening and diagnosing. This research addresses a new approach using photoacoustic (PA) imaging. The transmission properties of atherosclerosis within walls of arteries, can be exploited using photo acoustics, to better visualize and characterize the degree and severity of atherosclerosis. The delivered energy is absorbed by components of the vascular tissue converted into heat, leading to transient thermos elastic expansion, which creates an acoustic emission. The thermal response was analyzed for its fall and recovery times that are attributed to the artery fat type. The control parameters, including the frequency, penetration depth, energy levels, and tissue layer sizes, for multilayered structures were considered. The structures investigated were fatty infiltrate within the artery, blood, bones, and skin, within frequency range from 1 MHz to 3 MHz, and typical tissue sizes in the milli to centimeter range. As high as 14 MPas in the acoustic pressure at 1 MHz, resulted in temperature difference of up to 3.4 K. When the operating frequency was altered to 2 MHz, the temperature changed to 23 K. Furthermore, when the frequency was changed to 3 MHz, the te

关键词： Acoustic Thermal Cardiovascular Diagnosis MEMS/NEMS COMSOL Multilayers non-invasive

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：