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Immunohistochemical study of NR2C2, BTG2, TBX19, and CDK2 expression in 31 paired primary/recurrent non-functioning pituitary adenomas

Immunohistochemical study of NR2C2, BTG2, TBX19, and CDK2 ex...

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第十四届中国医师协会神经外科医师年会

作者： Xiaohui Yao Yazhuo Zhang Lijuan Wu Rui cheng Chuzhong LI Chongxiao QU Hongming Ji Shanxi provincial people's hospital Key laboratory of central nervous system injury research Beijing Neurosurgical InstituteCapital Medical University

This study investigated potential markers for predicting non-functioning pituitary adenoma(NFPA) invasion and recurrence by high-throughput tissue microarray analyses. We retrospectively studied two groups of patients, including 60 non-recurrent NFPA cases that included non-invasion and invasion subtypes, and 43 recurrent cases that included primary NFPA. A total of 31 paired patient samples were evaluated(12 patients with one surgery and 31 who had undergone two operations, with both tumors analyzed). Expressions of nuclear receptor subfamily 2 group C member 2(NR2C2), B cell translocation gene 2, T-box(TBX)19, and cyclin-dependent kinase(CDK)2 in surgically resected specimens were assessed by immunohistochemistry. The relationship between marker expression and clinical characteristics including age, sex, tumor volume, and follow-up time were analyzed. Tumor volume and invasion as well as follow-up time were significantly associated with invasion and recurrence(P non-recurrent samples, 15/41 and 13/19 showed high NR2C2 expression in the non-invasion and invasion groups, respectively(χ =5.287, P = 0.021). NR2C2 was also overexpressed in 43 primary recurrent cases(χ =5.433, P = 0.02), whereas CDK2(χ = 11.242, P = 0.001) and TBX19(χ = 4.875, P = 0.027) were downregulated. In the 31 paired samples, NR2C2 was more highly expressed in the recurrent as compared to the primary tumor. High NR2C2 expression was associated with NFPA invasion, recurrence, and progression,while TBX19 and CDK2 were associated with NFPA recurrence.

关键词： non-functioning pituitary adenoma NR2C2 BTG2 CDK2 TBX19 Immunohistochemistry

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