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Life’s Essential 8 and risk of non-communicable chronic diseases:Outcome-wide analyses

Chinese Medical Journal 2024年第13期137卷 1553-1562页

作者： Yuetian Yu Ying Sun Yuefeng Yu Yuying Wang Chi Chen Xiao Tan Yingli Lu Ningjian Wang Institute and Department of Endocrinology and Metabolism Shanghai Ninth People’s HospitalShanghai JiaoTong University School of MedicineShanghai 200011China School of Public Health Zhejiang UniversityHangzhou 310058ZhejiangChina Department of Medical Sciences Uppsala UniversityUppsala 75185Sweden

Background:Life’s Simple 7,the former construct of cardiovascular health(CVH)has been used to evaluate adverse non-communicable chronic diseases(NCDs).However,some flaws have been recognized in recent years and Life’s Essential 8 has been *** this study,we aimed to analyze the association between CVH defined by Life’s Essential 8 and risk of 44 common NCDs and further estimate the population attributable fractions(PAFs)of low-moderate CVH scores in the 44 ***:In the UK Biobank,170,726 participants free of 44 common NCDs at baseline were *** Life’s Essential 8 composite measure consists of four health behaviours(diet,physical activity,nicotine exposure,and sleep)and four health factors(body mass index,non-high density lipoprotein cholesterol,blood glucose,and blood pressure),and the maximum CVH score was 100 *** score was categorized into low,moderate,and high *** were followed up for 44 NCDs diagnosis across 10 human system disorders according to the International Classification of diseases 10th edition(ICD-10)code using linkage to national health records until *** proportional hazard models were used in this *** hazard ratios(HRs)and PAFs of 44 NCDs associated with CVH score were ***:During the median follow-up of 10.85 years,58,889 incident NCD cases were *** linear dose-response associations were found between higher CVH score and lower risk of 25(56.8%)of 44 ***-moderate CVH(chronic liver disease(45.9%),chronic kidney disease(40.9%),ischemic heart disease(40.8%),chronic obstructive pulmonary disease(40.0%),endometrium cancer(35.8%),lung cancer(34.0%),and heart failure(34.0%)as the top *** the eight modifiable factors,overweight/obesity explained the largest number of cases of incident NCDs in endocrine,nutritional,and me

关键词： Life’s Essential 8 Cardiovascular risk score non-communicable chronic disease Population health management Cohort analysis Healthy lifestyle UK Biobank

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