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non-allergic rhinitis in children: Epidemiological aspects, pathological features, diagnostic methodology and clinical management

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World Journal of Methodology 2016年第4期6卷 200-213页

作者： Dimitri Poddighe Matteo Gelardi Amelia Licari Michele Miraglia del Giudice Gian Luigi Marseglia Department of Pediatrics ASST Melegnanoe Martesana Department of Pediatric Sciences Università degli Studi di Pavia Department of Otolaryngology Università di Bari Department of Pediatrics Fondazione IRCCS Policlinico San Matteo Department of Pediatrics Seconda Università di Napoli Department of Pediatrics Fondazione IRCCS Policlinico San Matteo di Pavia

Chronic rhinitis is a very common disease, as the prevalence in the general population resulted to be 40%. allergic rhinitis has been considered to be the most frequent form of chronic rhinitis, as non-allergic rhinitis has been estimated to account for 25%. However, several evidences suggested that non-allergic rhinitis have been underrated, especially in children. In pediatrics, the diagnostic definition of non-allergic rhinitis has been often limited to the exclusion of an allergic sensitization. Actually, local allergic rhinitis has been often misdiagnosed as well as mixed rhinitis has not been recognized in most cases. Nasal cytology is a diagnostic procedure being suitable for routine clinical practice with children and could be a very useful tool to characterize and diagnose non-allergic rhinitis, providing important clues for epidemiological analysis and clinical management.

关键词： Pediatric chronic rhinitis non-allergic rhinitis Nasal cytology Local allergic rhinitis

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Localization of Active Caspase-3 and Caspase-8 in Nasal Polyps and Nasal Hyperplasia in Consideration of Mast Cell Function: A Semiquantitatively Analysis

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International Journal of Otolaryngology and Head & Neck Surgery 2012年第3期1卷 63-70页

作者： Nadine Franzke Sibylle Koehler Peter Middel Claudia Fuoco Francesco Cecconi Fabio Quondamatteo Rainer Laskawi Saskia Rohrbach Anatomy National University of Ireland Galway Ireland Department of Audiology and Phoniatrics Charite Medical University of Berlin Berlin Germany Department of Dermatology University Hamburg-Eppendorf Hamburg Germany Department of Histology University of Goettingen Goettingen Germany Department of Otorhinolaryngology University of Goettingen Goettingen Germany Dulbecco Telethon Institute Department of Biology University of Rome Tor Vergata Rome Italy Institute of Pathology Klinikum Kassel Kassel Germany

Introduction: The pathogenesis of nasal polyposis and nasal hyperplasia is still unknown. The localization of caspases in nasal polyps and nasal hyperplasia of patients with and without allergic rhinitis was studied. Methods: Sections of human nasal polyps (n = 5) and hyperplastic nasal turbinates (5 with, 5 without allergy) were stained for active caspase-3 and caspase-8. Double immunofluorescence was used to evaluate colocalization of the caspases with Ki-M1P and tryptase. TUNEL was performed. Results: Active caspase-3 and caspase-8 were seen in nearly all nasal polyps and hyperplastic nasal turbinates. Active caspase-3 was predominantly localized in stromal cells, identified as mast cells. Caspase-8 was localized in mast cells with the pattern similar to active caspase-3 and additionally found in epithelial cells at the nasal and polyp surface and in epithelial cells of glands. Conclusion: Our results suggest that mast cell apoptosis may be involved in the pathological mechanisms which characterize and sustain chronic inflammatory disorders of the nasal mucosa with and without allergy.

关键词： Nasal Polyposis Caspase-3 Caspase-8 allergic Rhinitis non-allergic Rhinitis Mast Cells Nasal Pathology Chronic Rhinosinusitis Apoptosis Nasal Hyperplasia

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