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Dabigatran in the Treatment of Extensive Cerebral Venous Thrombosis:A Case Report

World Journal of Neuroscience 2018年第1期8卷 32-37页

作者： Viviane Maria Vedana Luiz Carlos Porcello Marrone Nathalia Guarienti Missima William Alves Martins Camila Simeoni Luisa Franciscatto Ricardo Bernardi Soder Antonio Carlos Huf Marrone Department of Neurology Hospital Sao LucasPontificia Universidade Catolica do Rio Grande do Sul(PUCRS)Porto AlegreBrazil Brain Institute Pontificia Universidade Catolica do Rio Grande do Sul(PUCRS)Porto AlegreBrazil

Background: Cerebral venous thrombosis (CVT) is a rare type of cerebrovascular disease associated with a 15% rate of death or function dependence. The mainstay of treatment for CVT is systemic anticoagulation, despite venous hemorrhagic infarction. vitamin k antagonists have long been the only available option for anticoagulation;however, the past few years have brought the development of many new target-specific drugs, collectively called non-vitamin k antagonist oral anticoagulants (NOACs). Although emerging evidence suggests NOACs have an acceptable safety and tolerability profile in CVT, there are limited data available and no randomized controlled trials have been performed to date. Case Presentation: This describes the case of a patient with CVT occurring during an infection who was successfully treated with a NOAC, dabigatran, after a difficult time on warfarin. Conclusions: A case of extensive and deep CVT was identified. Dabigatran 150 mg treatment twice daily in this patient resulted in no additional damage to the brain. This case study illustrates that the use of NOACs such as dabigatran can be safe and effective in patients with CVT.

关键词： Cerebral Venous Thrombosis Dabigatran non-vitamin k antagonist oral anticoagulant Safety

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