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noninvasive identificational diagnosis of diabetic nephropathy and non-diabetic renal disease based on clinical characteristics of Traditional Chinese Medicine symptom pattern and conventional medicine

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Journal of Traditional Chinese Medicine 2023年第3期43卷 588-593页

作者： QU Yilun CHENG Haimei WANG Qian LI Shuang DUAN Shuwei FENG Zhe LI Weizhen JIANG Shuangshuang YANG Hongtao MAO Yonghui GENG Yanqiu LI Jijun LIU Yuning TIAN Jinzhou LIU Hongfang DONG Zheyi CHEN Xiangmei Department of Nephrology First Medical Center of Chinese PLA General HospitalNephrology Institute of the Chinese People's Liberation ArmyState Key Laboratory of Kidney DiseasesNational Clinical Research Center for Kidney DiseasesBeijing Key Laboratory of Kidney Disease ResearchBeijing 100853China Department of Nephrology The First Affiliated Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300381China Department of Nephrology Beijing HospitalBeijing 100730China Department of Nephrology the Third Medical Center of PLA General HospitalBeijing 100039China Department of Nephrology the Forth Medical Center of PLA General HospitalBeijing 100048China Department of Nephrology Dongzhimen Hospital of Beijing University of Traditional Chinese MedicineBeijing 100700China Three Departments of Encephalopathy Dongzhimen Hospital of Beijing University of Traditional Chinese MedicineBeijing 100700China Department of Endocrinology Dongzhimen Hospital of Beijing University of Traditional Chinese MedicineBeijing 100700China

OBJECTIVE:To study the clinical characteristics relating to differential diagnosis of diabetic nephropathy(DN) and non-diabetic renal disease(NDRD).METHODS:The subjects were patients with type 2 diabetes mellitus(T2DM) complicated with chronic kidney disease(CKD).Western medical history data and Traditional Chinese Medicine(TCM) symptom pattern were collected,and logistic regression was used to ***:Blood deficiency pattern [odds ratio(OR) = 2.269,P = 0.017] and Qi stagnation pattern(OR = 1.999,P = 0.041) are independently related to ***:TCM factors blood deficiency pattern and Qi stagnation pattern are relating to differential diagnosis of DN and NDRD.

关键词： diabetes mellitus type 2 renal insufficiency chronic diabetic nephropathies non-diabetic renal disease syndrome complex

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The Spectrum of Kidney disease in Type Two diabetic Patients: A Single-Center Study

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Open Journal of Nephrology 2022年第1期12卷 1-14页

作者： Amir Muse Mohamud Ning Xu Guangyi Liu Bekzod Odilov Bei Jiang Zhao Hu Department of Nephrology School of Medicine Cheeloo College of Medicine Shandong University Jinan China Department of Nephrology Qilu Hospital Cheeloo College of Medicine Shandong University Jinan China Department of Endocrinology School of Medicine Cheeloo College of Medicine Shandong University Jinan China Department of Endocrinology Qilu Hospital Cheeloo College of Medicine Shandong University Jinan China

Background: diabetic nephropathy (DN) is the dominant reason for end-stage kidney disease linked with a rise in cardiovascular mortality rate. However, besides DN, type 2 diabetic patients may also suffer from various non-diabetic renal diseases (NDRD). Aim: The objective of the current research was to assess the occurrence and type of NDRD diagnosed by kidney biopsy in type 2 diabetic subjects, evaluate the association of various clinical and laboratory characteristics with histopathology findings, and identify essential predictors of NDRD. Methods: Retrospective analysis has been performed through medical record revision of 101 patients with type 2 diabetes undergoing percutaneous renal biopsy at Qilu Hospital of Shandong University (Jinan, China) between January 2015 and December 2020. Results: renal biopsy results showed that NDRD was found in 59 patients (58.42%), while DN existed in 32 patients (31.68%) and 10 patients (9.90%) showed DN complicated with NDRD. Membranous nephropathy was prevailing NDRD (42%), followed by focal segmental glomerulosclerosis (11.6%) and IgA nephropathy (10.1%). In univariate analysis, patients with NDRD had older age (p Conclusions: Clinical parameters such as short duration of diabetes, older age, higher hemoglobin level, and lower proteinuria might be associated with NDRD in type 2 diabetic patients. An early diagnosis of NDRD poses a favorable renal prognosis because it requires a different approach than DN, further larger multicenter randomized prospective investigations focused on identifying possible risk markers of NDRD are still in priority.

关键词： Type-Two Diabetes Mellitus non-diabetic renal disease diabetic Nephropathy Kidney Biopsy

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