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Hepatoma Research 2018年第9期4卷 123-141页

作者： Arno Kornberg Martina Schernhammer Department of Surgery Klinikum rechts der IsarTechnical University MunichMunich D-81675Germany

Liver transplantation (LT) is recognized as best treatment option in patients with early hepatocellular cancer (HCC) in underlying liver cirrhosis. Apart from tumor size and number implemented in the Milan criteria, which are current worldwide standards for patient selection, several biological tumor factors have been identified to affect cancer-specific outcome. In particular, grading and vascular tumor invasions were shown to correlate with aggressive biological tumor behavior and poor survival following LT. Identifying tumors with favorable biology is one important approach for expanding the pool of eligible liver recipients beyond the Milan burden limits. Improving the immunological state and condition for appropriate defense against circulating cancer cell attack may be another important prognostic aspect. Therefore, there is increasing interest in non-cancer factors related to the peritransplant period that may influence the oncological outcome by providing negative immunomodulatory actions. Considering and modulation of these non-HCC factors of prognosis might contribute in safely expanding the HCC LT selection criteria.

关键词： Hepatocellular carcinoma liver transplantation tumor biology non-cancer factors outcome

Development of New COSMOS oral RepeatDose and non-cancer Threshold of Toxicological Concern（TTC） Databases to Support Alternative Assessment Methods for Cosmetics Related Chemicals

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Development of New COSMOS oral RepeatDose and non-cancer Thr...

Assessment of Endocrine Disrupting Trace Metals in River Samre at Samreboi in the Wassa Amenfi West District of the Western Region of Ghana

中国毒理学会第七次全国毒理学大会暨第八届湖北科技论坛

作者： Yang C Barlow S Boobis A Cronin MTD Felter SP Hollnagel HM Keller D Vitcheva V Worth AP Zhu T Altamira LLC Independent consultant Imperial College Liverpool John Moores University P&G Dow Europe GmbH Henkel EC Joint Research Center

In quantitative risk assessment,the Threshold of Toxicological Concern（TTC） approach provides a method to determine a conservative estimate of a chronic exposure below which there is a very low probability of *** TTC concept is a principle,which through a probabilistic approach,establishes human exposure levels for chemicals below which there would be no appreciable risk to human *** is reliant on existing oral toxicity data on a multitude of chemical classes to predict the toxicological potential of non-tested *** tiered TTC approach has 6 potency tiers covering 4 orders of magnitude（Kroes et al.2004）.The upper tiers are based on non-cancer data from a reference database of over 600 chemicals analyzed by Munro et al（1996） and grouped according to the Cramer et al（1978） decision tree according to chemical *** utility of TTC has been well established and accepted by regulatory bodies in a number of areas *** packaging migrants,flavor chemicals,genotoxic impurities in *** fact,low level constituents or contaminants in a cosmetic product often have insufficient toxicological data to make a full assessment of chronic *** one of the practical alternatives to repeated dose toxicity testing,the TTC approach is now being expanded to include cosmetics-related *** supports exposure-based safety assessment with a threshold for chemicals below which there is a low probability of a risk to *** EU Cosmetics Regulation requires replacement of animal testing of cosmetic products for repeated dose/reproductive toxicity and *** this end,the COSMOS consortium within SEURAT,a joint cluster between European Commission and Cosmetics Europe,has been engaged in development of computational methods and *** has developed a new toxicity database enriched with oral repeated dose studies for cosmetics-related chemicals.A new Cosmetics Inventory has been defined based on the chemical records from

关键词： Threshold of Toxicological Concern(TTC) risk assessment cosmetics non-cancer

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Journal of Water Resource and Protection 2013年第10期5卷 983-992页

作者： Matthew Nkoom Samuel Jerry Cobbina Michael Kumi Council for Scientific and Industrial Research Water Research Institute Tamale Ghana Department of Ecotourism and Environmental Management Faculty of Renewable Natural Resources University for Development Studies Nyankpala Campus Tamale Ghana

The rational for the study was to assess the levels of endocrine disrupting trace metals in River Samre. The levels of Mercury ranged from 0.01 to 0.02 mg/l (mean of 0.006 mg/l), whiles cadmium levels ranged from 0.002 to 0.011 mg/l (mean of 0.01 mg/l). The high levels of Hg and Cd may have adverse effects on the endocrine system of inhabitants who drink directly from the river without treatment. High levels of mercury and cadmium might be caused by the activities of a Timber and Plywood Company located close to the river and the underlying bedrocks of the area exposed as a result of human activities such as farming. The concentration of lead was below detection limit ( mg/l) but that of Arsenic ranged from 0.001 to 0.007 mg/l (mean of 0.005). Health risk assessment conducted shows that the risk associated with exposure to these metals for now are low. Continuous water quality monitoring is recommended to help protect the resource and also to safeguard human health.

关键词： Endocrine Disrupting Trace Metal Samreboi non-cancer Risk Assessment Hazard Quotient Surface Water

Serum Ferritin and D-Dimer as Possible Risk Factors in Ischaemic Stroke in cancer Patients

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World Journal of Neuroscience 2021年第4期11卷 307-317页

作者： Mohammed Abbas Ahmed Hady Mohamed Jawad Mohamed Mofreh Samer Salama Wessam Mustafa Neurology Department Faculty of Medicine Mansoura University Mansoura Egypt Clinical Oncology and Nuclear Medicine Department Faculty of Medicine Mansoura University Mansoura Egypt Department of Clinical Pathology Mansoura University Mansoura Egypt

Background: Ischemic stroke is frequently encountered in patients with malignant disease. The pathophysiology of stroke in such cases differs from other subjects with no malignant disease. This study was conducted to compare serum levels of ferritin and d-dimer in cases with ischemic stroke in cancer versus non-cancer patients. Patients and methods: The data of consecutive 264 patients presented with ischemic stroke, confirmed by clinical examination and radiological investigations, were retrospectively reviewed. The included cases were divided into two groups: Group A (non-cancer with stroke, 210 cases) and Group B (cancer with stroke, 54 cases). The collected data included patient demographics, systemic comorbidities, disease and tumor characteristics, in addition to platelet count, serum ferritin and d-dimer. Results: Age, gender, and systemic comorbidities were statistically comparable between the two groups. Additionally, the etiology of stroke and its disability were not statistically different between the two groups. However, the incidence of mortality significantly increased in Group B (25.93% vs. 7.14% of Group A, p = 0.005). Both serum ferritin and d-dimer showed a significant increase in association with cancer (Group B). The former had mean values of 294.54 and 867.87 ng/ml, while the latter had mean values of 463.83 and 888.13 ng/ml in the same two groups, respectively. Conclusion: Serum ferritin and d

关键词： Ischemic Stroke cancer non-cancer Risk Factors

Study on the clinical application of pain treatment efficacy evaluation and the nursing of patients with chronic noncancer pain

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Journal of Clinical and Nursing Research 2018年第2期2卷 13-16页

作者： Qian Han Yuping Liu Wen Shen Jie Chen Department of Oncology Affiliated Hospital of Xuzhou Medical University

Objective:To evaluate the pain degree of the patients with chronic non-cancer pain by using the evaluation model constituted by heart rate variability,anxiety and depression scale and quality of life rating scale,and to evaluate the efficacy after treatment and nursing ***:100 patients with chronic non-cancer pain treated in our hospital from February 2016 to April 2017 were selected to compare their heart rate variability,score of anxiety and depression,score of quality of life and NRS score before and after treatment and nursing ***:After treatment and nursing intervention,the heart rate variability time domain SDNN increased and the difference is significant(Pnon-cancer pain and to evaluate the efficacy after treatment and nursing intervention,which is worthy of clinic application.

关键词： Evaluation model Patients with chronic non-cancer pain Pain