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Whole-genome methylation reveals tissue-specific differences in non-cg methylation in bovine

Zoological Research 2024年第6期45卷 1371-1384页

作者： Jing Wang Wen Yuan Fang Liu Guang-Bo Liu Xiao-Xiong Geng Chen Li Chen-Chen Zhang Nan Li Xue-Ling Li State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestocks Inner Mongolia UniversityHohhotInner Mongolia 010070China

DNA methylation at non-cg dinucleotides(mCH,H=A,C,T)widely occurs and plays an important role in specific cell types,including pluripotent,neural,and germ ***,the functions and regulatory mechanisms of mCH,particularly in species other than humans and mice,remain inadequately *** this study,we analyzed the distribution of mCH across different bovine tissues,identifying significantly elevated mCH levels in bovine embryonic stem cells(bESCs),as well as brain,spleen,and ileum tissues compared to other *** differences in mCH patterns between somatic cells and bESCs were observed,reflecting distinct base preferences and the differential expression of DNA *** also identified exon methylation in both cg and noncg contexts,resembling gene-associated methylation patterns observed in *** characterize tissue-specific variations in mCH,we developed a novel method for differential mCH *** indicated that mCH is not randomly distributed but tends to be enriched in tissuespecific functional ***,regression models demonstrated a positional correlation between cg methylation and *** study enhances our understanding of mCH distribution and function in bovine somatic and stem cells,providing new insights into its potential roles across species and *** findings advance knowledge of epigenetic mechanisms,shedding light on the potential involvement of mCH in development and disease processes.

关键词： Epigenetics non-cg methylation CHDMRs Comparative Genomics Developmental Biology

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