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Efficacy of the nucleotide-binding oligomerization domain 1 inhibitor nodinhibit-1 on corneal alkali burns in rats

International Journal of Ophthalmology(English edition) 2015年第5期8卷 860-865页

作者： Xu Huang Yun Han Yi Shao Jing-Lin Yi Affiliated Eye Hospital of Nanchang University Fujian Provincial Key Laboratory of Ophthalmology and Visual Science Eye Institute of Xiamen University Department of Ophthalmology the First Affiliated Hospital of Nanchang University

AIM: To evaluate the therapeutic effect of nodinhibit-1 on alkali-burn-induced corneal neovascularization (CNV) and inflammation. The nucleotide-binding oligomerzation domain 1 (NOD1) is a potent angiogenic gene. METHODS: The alkali -burned rat corneas (32 right eyes) were treated with eye drops containing nodinhibit-1 or phosphate buffered solution (PBS, pH 7.4) only, four times per day. CNV and inflammation were monitored using slit lamp microscopy, and the area of CNV was measured by formula. Vascular endothelial growth factor (VEGF) and pigment epithelium -derived factor (PEDF) was determined by Western blot analysis. The TUNEL assay was used to assess the corneal apoptosis cells. RESULTS: Alkali-burn-induced progressive CNV and inflammation in the cornea. After treatment for 7d and 14d, there were statistically significant differences in the CNV areas and inflammatory index on that between two group(P1, 4, and 7 between the two groups showed significant differences at all time points (Pnodinhibit-1 groups on day 14(P10.0 mu g/mL nodinhibit -1 may have potential effect for the alkali burn -induced CNV and inflammation. The effect of nodinhibit -1 on CNV may be by regulation the equilibrium of VEGF and PEDF in the wounded cornea.

关键词： nodinhibit-1 inflammation alkali burn cornea neovascularization

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