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prognostic significance of pretreatment serum carcinoembryonic antigen levels in gastric cancer with pathological lymph node-negative: A large sample singlecenter retrospective study

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World Journal of Gastroenterology 2017年第48期23卷 8562-8569页

作者： Jun Xiao Zai-Sheng Ye Sheng-Hong Wei Yi Zeng Zhen-Meng Lin Yi Wang Wen-Hao Teng Lu-Chuan Chen Department of Gastrointestinal Surgery Fujian Cancer Hospital and Fujian Medical University Cancer Hospital

AIM To assess whether elevated serum carcinoembryonic antigen(CEA) is in the inferior prognosis for pathological lymph node-negative(p N_0) gastric cancer(GC) patients who underwent D_2 *** About 469 p N0 GC patients,who received D^2 radical gastrectomy were retrospectively analyzed. The X-tile plots cut-off point for CEA were 30.02 ng/m L using minimum P-value from log-rank χ~2 statistics,and p N_0 GC patients were assigned to two groups: those more than 30.02 ng/m L(n = 48;CEA-high group) and those less than 30.02 ng/m L(n = 421;CEA-low group). Clinicopathologic characteristics were compared usingPearson's χ2 or Fisher's exact tests,and survival curves were so manufactured using the Kaplan-Meier method. Univariate and multivariate analysis were carried out using the logistic regression *** The percentage of vessel carcinoma embolus(31.35% vs 17.1%) and advanced GC(T_(2-4b))(81.25% vs 65.32%) were higher in CEA-high group than CEA-low group. The CEA-positive patients had a significantly poorer prognosis than the CEA-nagetive patients in terms of overall survival(57.74% vs 90.69%,P 0.05). Multivariate survival analysis showed that CEA(OR = 4.924),and T category(OR = 2.214) were significant prognostic factors for stage p N0 GC(all P < 0.05). Besides,only T category(OR = 1.962) was an independent hazard factor in the CEA-high group(P < 0.05).CONCLUSION Those pretreatment serum CEA levels over 30.02 ng/m L on behalf of worse characteristics and unfavourable tumor behavior,and a poor prognosis for a nearly doubled risk of mortality in GC patients.

关键词： Carcinoembryonic antigen Gastric cancer Pathological lymph node-negative X-tile plots 5-year survial rate

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Prognostic value of number of examined lymph nodes in patients with node-negative gastric cancer

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World Journal of Gastroenterology 2014年第13期20卷 3640-3648页

作者： Xu-Guang Jiao Jing-Yu Deng Ru-Peng Zhang Liang-Liang Wu Li Wang Hong-Gen Liu Xi-Shan Hao Han Liang Key Laboratory of Cancer Prevention and Therapy Department of Gastrointestinal Oncology Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for Cancer

AIM: To elucidate the potential impact of examined lymph nodes (eLNs) on long-term survival of node-negative gastric cancer patients after curative surgery.

关键词： Gastric carcinoma Examined lymph nodes node-negative Prognosis

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Expression and prognostic value of plasminogen activator inhibitor type 1 in node-negative breast cancer

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The Chinese-German Journal of Clinical Oncology 2008年第6期7卷 339-343页

作者： Bin Wang Ning Wang Chunyan Xue Bin Jiang Yajie Wang Department of Oncology Changhai Hospital The Second Military Medical University Shanghai 200433 China Department of Oncology The Third People＇s Hospital Affiliated to Jiao Tong University Shanghai 201900 China

Objective： To investigate the expressions of plasminogen activator inhibitor type 1 （PAl-1）, C-erbB-2, VEGF and Ki-67 by immunohistostaining and then to evaluate the prognostic value of PAl-1 in node-negative breast cancer. Methods： The study included a retrospective series of 62 female patients with axillary lymph node-negative breast cancer. Expressions of PAl-1, C-erbB-2, VEGF and Ki-67 were determined by immunohistostaining on formalin-fixed paraffin-embedded tissue sections from these patients after a median follow-up of 69 months （range 22-117 months）. Correlations with well known clinicopathologic factors were assessed and multivariate survival analyses were performed. Results： High PAl-1 level was positively associated with high histologic grade of the tumors. Disease-free survival （DFS） was significantly shorter for the patients with moderate to intensive expression of PAl-1 than for those with negative （χ^2 = 25.46, P 〈 0.001; χ^2 = 23.07, P 〈 0.001） to mild expression （χ^2 = 19.75, P 〈 0.001; χ^2 = 17.40, P 〈 0.001）. Although on univariate analysis of the prognostic factors, tumor size, location of primary tumor and age as well as expressions of PAl-1, VEGF and Ki-67 were all significantly prognostic factors for DFS （P 〈 0.05）, PAl-1 was the only independent prognostic factor on multivariate analysis （P 〈 0.0001; hazard ratio [HR], 4.041; 95% confidence interval [CI], 1.928-8.468）. Conclusion： These results of the current study indicate that intermediate or high expression of PAl-1 represents a strong and independent unfavorable prognostic factor for the development of recurrence or metastases in axillary node-negative breast cancer.

关键词： breast carcinoma node-negative plasminogen activator inhibitor type 1 (PAl-1) prognosis

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Early stage colon cancer

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World Journal of Gastroenterology 2013年第46期19卷 8468-8473页

作者： Hugh James Freeman Department of Medicine University of British Columbia

Evidence has now accumulated that colonoscopy and removal of polyps,especially during screening and surveillance programs,is effective in overall risk reduction for colon *** resection of malignant pedunculated colon polyps or early stage colon cancers,long-term repeated surveillance programs can also lead to detection and removal of asymptomatic high risk advanced adenomas and new early stage metachronous *** stage colon cancer can be defined as disease that appears to have been completely resected with no subsequent evidence of involvement of adjacent organs,lymph nodes or distant *** differs from the clinical setting of an apparent"curative"resection later pathologically upstaged following detection of malignant cells extending into adjacent organs,peritoneum,lymph nodes or other distant sites,including *** highly selected early stage colon cancer group remains at high risk for subsequent colon polyps and metachronous colon *** staging is important,not only for assessing the need for adjuvant chemotherapy,but also for patient selection for continued *** advanced stages of colon cancer and a more guarded outlook,repeated surveillance should be *** future,novel imaging technologies(e.g.,confocal endomicroscopy),coupled with increased pathological recognition of high risk markers for lymph node involvement(e.g.,"tumor budding")should lead to improved staging and clinical care.

关键词： Colon cancer node-negative colon cancer Staging of colon cancer Nodal micrometastases Follow-up and surveillance of early colon cancer

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