检索结果-南通市图书馆

Recent advances in diverse nanosystems for nitric oxide delivery in cancer therapy

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2023年第4期13卷 1498-1521页

作者： Dan Gao Sajid Asghar Rongfeng Hu Su Chen Ruixin Niu Jia Liu Zhipeng Chen Yanyu Xiao State Key Laboratory of Natural Medicines China Pharmaceutical UniversityNanjing 210009China Faculty of Pharmaceutical Sciences Government College University FaisalabadFaisalabad 38000Pakistan Anhui Province Key Laboratory of Pharmaceutical Preparation Technology and Application Hefei 230012China Jiangyin Hospital Affiliated to Nanjing University of Chinese Medicine Jiangyin 214499China Department of Pharmacy Nanjing University of Chinese MedicineNanjing 210023China

Gas therapy has been proven to be a promising and advantageous treatment option for *** have shown that nitric oxide(NO)is one of the smallest structurally significant gas molecules with great potential to suppress ***,there is controversy and concern about its use as it exhibits the opposite physiological effects based on its levels in the ***,the anti-cancer mechanism of NO is the key to cancer treatment,and rationally designed NO delivery systems are crucial to the success of NO biomedical *** review summarizes the endogenous production of NO,its physiological mechanisms of action,the application of NO in cancer treatment,and nano-delivery systems for delivering NO ***,it briefly reviews challenges in delivering NO from different nanoparticles and the issues associated with its combination treatment *** advantages and challenges of various NO delivery platforms are recapitulated for possible transformation into clinical applications.

关键词： nitric oxide nitric oxide donor nitric oxide-based delivery system Anti-cancer Binding mechanisms Synergistic treatment strategy Inorganic platforms Organic platforms

Discovery and bioassay of disubstituted β-elemene-NO donor conjugates:synergistic enhancement in the treatment of leukemia

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Natural Medicines 2023年第12期21卷 916-926页

作者： ZHU Junlong JIANG Xiaoying LUO Xinyu GAO Yuan ZHAO Rui LI Junjie CAI Hong DANG Xiawen YE Xiangyang BAI Renren XIE Tian School of Pharmacy Hangzhou Normal UniversityHangzhou 311121China Key Laboratory of Elemene Class Anti-cancer Chinese Medicines Engineering Laboratory of Development and Application of Traditional Chinese MedicinesCollaborative Innovation Center of Traditional Chinese Medicines of Zhejiang ProvinceHangzhou Normal UniversityHangzhou 311121China

Natural products are essential sources of antitumor *** such molecule,β-elemene,is a potent antitumor compound extracted from Curcuma *** the present investigation,a series of novel 13,14-disubstituted nitric oxide(NO)-donorβelemene derivatives were designed,withβ-elemene as the foundational compound,and subsequently synthesized to evaluate their therapeutic potential against ***,the derivative labeled as compound 13d demonstrated a potent anti-proliferative activity against the K562 cell line,with a high NO *** vivo studies indicated that compound 13d could effectively inhibit tumor growth,exhibiting no discernible toxic ***,a significant tumor growth inhibition rate of 62.9%was observed in the K562 xenograft tumor mouse *** accumulated data propound the potential therapeutic application of compound 13d in the management of leukemia.

关键词： Antitumor activity Chronic myeloid leukemia β-elemene nitric oxide donor Structural modification

New techniques and strategies in drug discovery

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2020年第7期31卷 1695-1708页

作者： Jintong Du Jing Guo Dongwei Kang Zhihong Li Guan Wang Jianbing Wu Zhen Zhang Hao Fang Xuben Hou Zhangjian Huang Guobo Li Xiaoyun Lu Xinyong Liu Liang Ouyang Li Rao Peng Zhan Xiaojin Zhang Yihua Zhang Shandong Cancer Hospital and Institute Shandong First Medical University and Shandong Academy of Medical SciencesJi'nan 250117China School of Pharmacy Ji'nan UniversityGuangzhou 510632China Department of Medicinal Chemistry Key Laboratory of Chemical Biology(Ministry of Education)School of Pharmaceutical SciencesShandong UniversityJi'nan 250012China Department of Chemistry Jiangsu Key Laboratory of Drug Design and OptimizationChina Pharmaceutical UniversityNanjing 211198China Stare Key Laboratory of Biotherapy and Cancer Center West China Hospitaland Collaborative Innovation Center of BiotherapySichuan UniversityChengdu 610041China Stare Key Laboratory of Natural Medicines Jiangsu Key Laboratory of Drug Discovery for Metabolic DiseasesChina Pharmaceutical UniversityNanjing 210009China Key Laboratory of Drug Targeting and Drug Delivery System of Ministry of Education West China School of PharmacySichuan UniversityChengdu 610041China Key Laboratory of Pesticide&Chemical Biology(CCNU) Ministry of EducationDepartment of ChemistryCentral China Normal UniversityWuhan 430079China

Great success has been witnessed in last decades,some new techniques and strategies have been widely used in drug *** this roadmap,several representative techniques and strategies are highlighted to show recent advances in this filed.(A)A DOX protocol has been developed for accurate protein-ligand binding structure prediction,in which first principle method was used to rank the binding *** against crystal structures have found that DOX prediction achieved an impressive success rate of 99%,indicating significant improvement over molecular docking method.(B)Virtual target profiling is a compound-centric strategy enabling a parallel implementation of interrogating compounds against various targets in a single screen,which has been used in hit/lead identification,drug repositioning,and mechanism-of-action *** and emerging methods for virtual target profiling are briefly summarized herein.(C)Research on targeted autophagy to treat diseases has received encouraging ***,due to the complexity of autophagy and disease,experimental and in silico methods should be performed synergistically for the entire *** part focuses on in silico methods in autophagy research to promote their use in medicinal research.(D)Histone deacetylases(HDACs)play important roles in various biological functions through the deacetylation of lysine *** studies demonstrated that HDACs,which possess low deacetylase activities,exhibited more efficient defatty-acylase ***,we review the defatty-acylase activity of HDACs and describe examples for the design of isoform selective HDAC inhibitor.(E)The FDA approval of three kinase allosteric inhibitors and some others entering clinical study has spurred considerable interests in this targeted drug discovery area.(F)Recent advances are reviewed in structure-based design of novel antiviral agents to combat drug resistance.(G)Since nitric oxide(NO)exerts anticancer activity depending on

关键词： Protein-ligand binding structure Target profiling In silico autophagy method Defatty-acylase Allosteric kinase inhibitor Drug resistance nitric oxide donor Photoactivation strategies

Preventive Effects of Nitroglycerine on Glucocorticoid-induced Osteoporosis in Growing Rats

在线全文

学校读者我要写书评

暂无评论

Journal of Huazhong University of Science and Technology(Medical Sciences) 2007年第5期27卷 528-531页

作者：李裕明李永国杨卫红 Department of Endocrinology Union Hospital Tongji Medical College Huazhong Universityof Science and Technology

The preventive effects of nitroglycerine （NG） on glucocorticoid-induced osteoporosis in growing rats were studied. Three-month-old female Wistar rats were randomly divided into control group （CON）, dexamethasone group （DXM）, DXM plus a low dose NG group （NG-L）, DXM plus a middle dose NG group （NG-M） and DXM plus a high dose NG group （NG-H）, 8 rats in each group. The rat model of osteoporosis was developed by intramuscular injection of dexamethasone twice a week. NG 0.2, 0.4 and 1.0 mg/kg was administered by oral gavages to the treatment groups every day for 12 weeks. Rats in CON group and DXM group were treated with normal saline of the same amount. After the treatment, the bone mineral density （BMD） and bone metabolism-associated biochemical markers were determined. Compared with CON group, BMD of lumbar spine and femur in DXM group was decreased significantly （P〈0.05 and P〈0.01 respectively）, blood BGP levels and NO levels reduced （both P〈0.01）, and TRAP level increased （P〈0.05）. As compared with DXM group, BMD, serum BGP and NO were increased, and TRAP decreased in NG-L group and NG-M group, but had no significant difference in comparison to CON group. All the markers other than serum NO and TRAP levels had no significant difference between NG-H group and DXM group. It was concluded that low or middle doses of NG could prevent glucocorticoid-induced bone loss in growing rats, but high dose of NG could not. Supplement with NO donor could be considered as a preventive treatment for glucocorticoid-induced osteoporosis in a developing skeleton.

关键词： glucocorticoid-induced osteoporosis nitroglycerin nitric oxide nitric oxide donor

Effect of inhalation of nebulized NO donor substance on acute hypoxic lung injury in newborn piglets

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2008年第17期121卷 1622-1626页

作者： XIA Hong-ping HUANG Guo-ying ZHU Jian-xing SUN Bo Department of Paediatrics Children's Hospital of Fudan University Shanghai Medical College Shanghai 200032 China Department of Neonatalogy Xinhua Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200092 China

Background Birth asphyxia may result in multiple organ dysfunction such as lung injury. Inhalation of nebulized nitric oxide precursor can selectively reduce pulmonary hypertension. However, it is unknown whether such precursors can alleviate lung injury induced by hypoxia. We evaluated the effect of inhalation of nebulized nitroglycerine and sodium nitroprusside on acute hypoxic lung injury in newborn piglets. Methods Acute hypoxic lung injury was induced by inspiring 10% 02 for 1 hour. Twenty-four anaesthetized and mechanically ventilated piglets （5-7 days old） were randomly divided into four groups：（1） group S, not hypoxic; （2） group C, nebulized saline after hypoxia; （3） group NTG, nebulized nitroglycerine after hypoxia; （4） group SNP, nebulized sodium nitroprusside after hypoxia, Respiratory dynamic compliance and resistance of respiratory system were recorded at baseline, 0.5 hour and 1 hour of hypoxia; then 0.5 hour, 1 hour, 3 hours and 5 hours following hypoxia. After nebulization, arterial blood was collected for measuring methaemoglobin and nitrate/nitrite levels. Right lung tissue, wet-dry ratio and myeloperoxidase level were determined. White blood cell count （WBC）, total surfactant phospholipids （TPL） and disaturated phosphatidyl choline （DSPC） of the bronchoalveolar lavage fluid （BALF） were calculated. Left lungs were used for examining pathological changes. Results No significant difference was observed in respiratory dynamic compliance, resistance of respiratory system, wet-dry ratio, levels of methaemoglobin and nitrate/nitrite after nebulization, TPL or DSPC/TPL among four groups. WBC in BALF in groups NTG and SNP significantly decreased as compared with group C： similarly for myeloperoxidase level in lung tissue. Lung histological findings showed infiltration of neutrophils in groups NTG and SNP decreased significantly as compared with group C. Conclusion Inhalation of nebulized nitroglycerine or sodium nitroprusside can alleviate the infiltratio

关键词： hypoxia newborn nitric oxide donor nitroglycerine sodium nitroprusside

Effect of Modified HIF-1<i>α</i>Linked to Carbonic Anhydrase IX Inhibitor and Glycosylated Cisplatin on Solid Tumors: Short Review

在线全文

学校读者我要写书评

暂无评论

Journal of Biosciences and Medicines 2021年第8期9卷 59-72页

作者： Waleed O. Atta Ahmed Z. Abdel Azeiz Faculty of Medicine Assiut University Sohag Egypt College of Biotechnology Misr University for Science and Technology (MUST) Giza Egypt

Many cancer cells in solid tumors are hypoxic or pseudohypoxic and create acidic environment for malignancy progression. Under low oxygen conditions (hypoxia), hypoxia-inducible factors (HIFs) play pathological roles in cancer cell survival and spreading. HIF regulates several genes such as genes of glucose transporters that enhance anaerobic glycolysis, angiogenesis, erythropoiesis and carbonic anhydrase IX (CA-IX). CA-IX is a cell-surface glycoprotein that catalyzes the hydration of CO2 to protons and bicarbonate ions (respiratory acidification). This process is involved in adaptation to acidosis and implicated in cancer progression. Therefore, CA-IX inhibitors (such as sulfonamide-based compounds) showed hoping results in reduction malignancy progression. The article aims to reversal the malignant hypoxic environment in solid tumors to create a condition of weakness within the cancer for further focused cisplatin potency. This article suggests the use of modified synthesized HIF as a drug delivery molecule for both carbonic anhydrase IX inhibitor and glycosylated cisplatin that damages the DNA of malignant cell. HIF molecule has high affinity to bind with CA IX-expressing malignant cells, which is followed by cell entrance via endocytosis. Once the HIF-Cisplatin-CA-inhibitor complex enters the cell, the carbonic anhydrase inhibitor will improve the cellular pH that makes the environment unsuitable for HIF 1α function and it may be ubiquitinated. So, the raise in target genes transcription will be arrested. On the other hand, once the synthetized HIF is degraded, the cisplatin molecules will be released inside the malignant cell and start to damage its DNA. This approach may be a good solution for many solid tumors.

关键词： Hypoxia Carbonic Anhydrase Cancer Cisplatin nitric oxide donor Glycosylation