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Acta Pharmacologica Sinica 2006年第12期27卷 1575-1579页

作者： Ping HAN Zheng-xu CHU Fu-ming SHEN He-hui XIE Ding-feng SU~2 Department of Pharmacology,School of Pharmacy,Second Military Medical University,Shanghai 200433,China Department of Pharmacology School of Pharmacy Second Military Medical University Shanghai China

Aim:To investigate the possible synergism of hydrochlorothiazide andnitrendipine on reducing both blood pressure(BP)and blood pressure variabil-ity(BPV)in spontaneously hypertensive rats(SHR).Methods:Seventy ani-mals were randomly divided into seven *** doses were 5 and 10 mg/kgfor nitrendipine,10 and 20 mg/kg for hydrochlorothiazide and 10+5,20+10mg/kg,respectively,for the combination of these two drugs and 0.8% carboxym-ethylcellulose as *** drugs were given via a catheter of gastric *** was then continuously recorded for 5h from 1h before drug administrationto the end of 4th hour after drug administration,in conscious and freely ***:The effects on both BP and BPV reduction of the combination ofhydrochlorothiazide and nitrendipine were greater than the single drug in *** two drugs possessed an obvious synergism on both systolic blood pressure(q=1.79 with small dose and q=1.23 with large dose)and systolic blood pres-sure variability reduction(q=1.79 with small dose and q=1.39 with large dose)in ***:The present work clearly demonstrated that there was asynergistic effect between hydrochlorothiazide and nitrendipine in lowering andstabilizing BP in SHR.

关键词： blood pressure blood pressure variability hydrochlorothiazide hypertension nitrendipine spontaneously hypertensive rat

Pharmacokinetic performance of the nitrendipine intravenous submicron emulsion in rats

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Asian Journal of Pharmaceutical Sciences 2014年第6期9卷 330-335页

作者： Jibin Guan Nana Zhao Yinglei Zhai Chunxia Chu Hongming Chen Tianhong Zhang Shenyang Pharmaceutical University School of PharmacyNo.103Wenhua RoadShenyang 110016China

To compare pharmacokinetic behaviors of nitrendipine submicron emulsion with nitrendipine solution following intravenous administration in *** plasma concentrations were analyzed by ultra-performance liquid chromatography coupled with tandem mass spectrometry detection(UPLC-MS/MS)through a new validated *** pharmacokinetic parameters of the nitrendipine submicron emulsion and nitrendipine solution were as follows:AUC_(0-t) 900.76±186.59 versus 687.08±66.24 ng h/ml,C_(max) 854.54±159.48 versus 610.59±235.99 ng/ml,t_(1/2)2.37±1.99 versus 2.80±2.69 *** relative bioavailability of nitrendipine submicron emulsion to nitrendipine solution was 131.4±11.3%.The developed methods could meet the requirements of *** to the solution injection,intravenous submicron emulsion presents higher systematic exposure which can help to improve the therapeutic efficacy.

关键词： nitrendipine Submicron emulsion Bioavailability Method validation

MULTICENTER　PARALLEL　STUDY　OF　AMLODIPINE　VERSUS　nitrendipine　IN　THE　TREATMENT　OF　ESSENTIAL　HYPERTENSION

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Medical Bulletin of Shanghai Jiaotong University 1995年第2期18卷 44-52页

作者：王宪衍龚兰生郭冀珍王孝铭刘玉慧叶绪英张国元杨培林

In a multicenter, randomized single blind and parallel study, 488 patients with essential hypertension received 4 weeks treatment with amlodipine or nitrendipine. The response rate of amlodipine is 90.4%, higher than that of nitrendipine, and the adverse reactions were less than those of nitrendipine. Hence amlodipine is a safe and effective antihypertensive agent. Its once-daily dose (5-10mg) makes it very convenient for clinical use.

关键词： amlodipine nitrendipine essential hypertension calcium antagonist

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参加尼群地平(nitrendipine)国际工作会议观感

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中国药学杂志 1983年第1期 53-54页

作者：陈修

钙通道阻滞剂又称钙拮抗剂,近年来在欧美等国受到很大重视。1979年11月在墨西哥举行了"国际第一次钙、钙拮抗剂和心血管病"专题会议(会议文集见Chest1980年第7期);不到两年又在1981年5月在墨西哥举行了第二次国际专题会议。心血管病期... 详细信息

钙通道阻滞剂又称钙拮抗剂,近年来在欧美等国受到很大重视。1979年11月在墨西哥举行了"国际第一次钙、钙拮抗剂和心血管病"专题会议(会议文集见Chest1980年第7期);不到两年又在1981年5月在墨西哥举行了第二次国际专题会议。心血管病期刊也纷纷出刊钙通道阻滞剂的专辑,以美国心脏病杂志(AmJ Cardiol)为例,1980年出过硝苯吡啶(nifedipine)的专辑,今年(1982)2月又请著名心血管药理学家*** 教授主编一期"心血管病与钙拮抗剂专辑",今年10月又出刊了1981年8月美国食品药物管理局(FDA)批准"应用戊脉安(verapamil)治疗心绞

关键词：会议 nitrendipine 戊脉安抗心律失常药钙拮抗剂心血管药理学尼群地平

Ⅰ.高血压临床随访的意义 Ⅱ.多个研究中心用nitrendipine治疗轻度至中度高血压的结果

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国外医学.心血管疾病分册 1987年第4期 206-207页

作者： Moser M 孙静平

根据美国退伍军人管理局协作研究组、澳大利亚国家心脏基金委员会和高血压普查及随访组(HDFP)的资料,很多医生对收缩期和舒张期血压都高的老年病人已常规地进行治疗.欧洲高血压研究会(EWPHE)针对60岁以上老年高血压患者是否需要治疗的... 详细信息

根据美国退伍军人管理局协作研究组、澳大利亚国家心脏基金委员会和高血压普查及随访组(HDFP)的资料,很多医生对收缩期和舒张期血压都高的老年病人已常规地进行治疗.欧洲高血压研究会(EWPHE)针对60岁以上老年高血压患者是否需要治疗的问题进行了大规模的研究,其结果对临床医生有重要的实用意义.此组研究中包括840人,平均年龄为70.5岁,治疗前血压为182～

关键词：高血压 nitrendipine 中度钙通道阻滞剂

Simultaneous Determination of Ticlopidine Hydrochloride and nitrendipine in a New Tablet Formulation by HPLC

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Journal of Beijing Institute of Technology 2002年第4期11卷 378-382页

作者：齐美玲王鹏顾峻岭北京理工大学化工与材料学院北京100081 沈阳华泰药物研究所沈阳110015

An accurate, simple and sensitive high performance liquid chromarographic (HPLC) method for simultaneous determination of ticlopidine hydrochloride and nitrendipine in a new tablet formulation is described. Chromatographic separation of ticlopidine hydrochloride and nitrendipine was achieved on a Hypersil BDS C18 column using a mobile phase consisting of acetonitrile-methanol-10 mmol/L ammonium acetate (60∶10∶30(V/V), pH 6.5) at a flow rate of 1.0 mL/min. Absorbance was monitored at 236 nm where both drugs have significant absorption. The proposed method was validated with respect to linearity, selectivity, accuracy, precision, and limits of detection and quantitation. The linear ranges for ticlopidine hydrochloride and nitrendipine were found to be 75-750 μg/mL and 1-10 μg/mL, respectively. The mean recoveries were 100.1%(S R=0.6%,n=9) for ticlopidine hydrochloride and 99.9%(S R=0.7%,n=9) for nitrendipine. The within-day precision and between-day precision for ticlopidine hydrochloride and nitrendipine were 0.63% and 0.89%, and 0.74% and 1.0%, respectively. The proposed HPLC method can be used for the simultaneous determination of both drugs in pharmaceutical preparations.

关键词： HPLC determination ticlopidine hydrochloride nitrendipine

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尼群地平(nitrendipine)对麻醉犬心血管作用的研究

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现代医学 1986年第2期 73-75+130页

作者：苏茂林濮家伉段明钧贺广远南京铁道医学院药理教研室

本文报道尼群地平静注不同剂量对麻醉犬的血流动力学及血管阻力的影响。结果表明,尼群地平能使动脉血压和外周阻力下降;冠状动脉和颈内动脉阻力下降较股动脉显著。在降压的同时,心泵和收缩性能指标增加,心率变化不明显。

关键词：麻醉犬血流动力剂量用药量尼群地平 nitrendipine

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尼群地平nitrendipine

药学进展 1987年第4期 49-50页

作者：夏蓬

本品为二氢吡啶类钙拮抗剂,由西德Bayer AG 药厂研究开发。1981年10月在美国纽约召开的国际性专题讨论会上,美国、英国、西德、瑞典、瑞士、加拿大等15个国家105位专家经过讨论,确认本品是一个口服有效的降压药物。1984年临床药理学家Al... 详细信息

本品为二氢吡啶类钙拮抗剂,由西德Bayer AG 药厂研究开发。1981年10月在美国纽约召开的国际性专题讨论会上,美国、英国、西德、瑞典、瑞士、加拿大等15个国家105位专家经过讨论,确认本品是一个口服有效的降压药物。1984年临床药理学家Alexander Scriabine 等将世界各地有关本品的研究资料汇编成专著“nitrendipine”出版。大量的药理与临床资料表明本品降压

关键词：美元西德本位币德国本品 nitrendipine

nitrendipine松弛兔胸主动脉条和保护大鼠缺血性心肌的实验研究(摘要)

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昆明医科大学学报 1991年第1期 25-25页

作者：王雪倩张子昭蒋家雄昆明医学院 87级药理学研究生

nitrendipine(尼群地平,硝苯乙吡啶)为新型二氢吡啶类钙拮抗剂,它具有良好的降压作用。一般认为 nitrendipine 主要通过阻滞 Ca经电位依赖性通道(PDC)内流,降低细胞内 Ca水平,使血管平滑肌舒张而降压。但也有一些研究表明,

关键词：兔胸主动脉条大鼠心肌 nitrendipine 缺血性

Two useful methods for evaluating antihypertensive drugs in conscious freely moving rats

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Acta Pharmacologica Sinica 2004年第2期25卷 22-25页

作者： Ding-feng SU2, Li-ping XU, Chao-yu MIAO, He-hui XIE, Fu-ming SHEN, Yuan-ying JIANG Department of Pharmacology, Second Military Medical University, Shanghai 200433, China Department of Pharmacology Second Military Medical University 上海 200433

AIM: Computerized analysis of blood pressure in conscious freely moving rats is a sound technique for physiologi- cal and pharmacological studies. The present work, based on this technique, was designed to introduce two useful methods for the evaluation of antihypertensive drugs in conscious spontaneously hypertensive rat (SHR). They were the directly intragastric administration of drugs and modified probability sum test for evaluating the synergism of the combination of two drugs. METHODS AND RESULTS: (1) Directly intragastric administration was used in conscious rats. A catheter was inserted into stomach immediately after arterial catheter insertion. Three days after operation, blood pressure was recorded and drug might be given intragastically via the gastric catheter. (2) Modi- fied probability sum test was used to evaluate the synergism of two drugs. The formula was: q=PA+B/(PA+PB?PA×PB). With this method, it was obtained: q=1.32 for the effects of the combination of atenolol and nitrendipine (20 mg/kg+10 mg/kg) on systolic blood pressure; q=1.41 for the effects of the combination of atenolol and amlodipine (10 mg/ kg+1 mg/kg) on systolic blood pressure. CONCLUSION: The two methods introduced by the present work will be important and useful for antihypertensive drug evaluation in conscious freely moving rats.

关键词： amlodipine atenolol blood pressure nifedipine nitrendipine spontaneously hypertensive rat