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nitrate-induced Biochemical and Histopathological Changes in the Liver of Rats:Ameliorative Effect of Hyparrhenia hirta

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Biomedical and Environmental Sciences 2014年第9期27卷 695-706页

作者： Hanen BOUAZIZ-KETATA Ghada BEN SALAH Hichem BEN SALAH Rim MARREKCHI Kamel JAMOUSSI Tahia BOUDAWARA Faiza FAKHFEKH Najiba ZEGHAL Animal Physiology Laboratory UR/11 ES70Sfax Faculty of SciencesUniversity of SfaxBP1171Sfax 3000Tunisia Laboratory of Human Molecular Genetics Faculty of MedicineSfax 3029Tunisia Laboratory of Chemistry Sfax Faculty of SciencesUniversity of SfaxBP1171Sfax 3000Tunisia Laboratory of Biochemistry CHU Hedi ChakerSfax 3029Tunisia Histopathology Laboratory University of SfaxCHU Habib BourguibaSfax 3029Tunisia

Objective The present study investigated the protective role of Hyparrhenia hirta （H. hirta） against sodium nitrate （NaNO3）-induced hepatoxicity. Methods Male Wistar rats were randomly divided into three groups： a control group and two treated groups during 50 d with NaNO3 administered either alone in drinking water or co-administered with H. hit＇to. Results NaNO3 treatment induced a significant increase in serum levels of glucose, total cholesterol and triglyceride while serum total protein level decreased significantly. Transaminases and lactate deshydrogenase activities in serum were elevated indicating hepatic cells＇ damage after treatment with NaNO3. The hyperbilirubinemia and the increased serum gamma glutamyl transferase activities suggested the presence of cholestasis in NaNO3 exposed rats. In parallel, a significant increase in malondialdehyde level along with a concomitant decrease in total glutathione content and superoxide dismutase, catalase and glutathione peroxidase activities were observed in the liver after NaNO3 treatment. Furthermore, nitrate caused a significant induction of DNA fragmentation. These modifications in NaNO3-treated rats corresponded histologically with hepatoceltular necrosis and mononuclear cells infiltration. H. hirta supplementation showed a remarkable amelioration of the abnormalities cited above. Conclusion The results concluded that the treatment with H. hirta had a significant role in protecting the animals from nitrate-induced liver dysfunction.

关键词： Antioxidant Hyparrhenia hirta Liver nitrate toxicity Oxidative stress Rat

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An alternative model for fetal loss disorders associated with mare reproductive loss syndrome

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Animal Nutrition 2020年第2期6卷 217-224页

作者： Thomas W.Swerczek Department of Veterinary Science University of KentuckyLexingtonKY40356United States

Fertile chicken eggs were used as an alternative model for large animals to evaluate suspect toxic dietary ingredients for fetal loss disorders associated with mare reproductive loss syndrome(MRLS) and fetal losses in other ***,ammonia,and sulfate may react with proteinaceous compounds to enable the formation of abiotic pathogenic nanoparticles which were constant findings in pathognomonic placental lesions associated with non-infectious fetal losses of previously unknown etiology in mares,chickens and other *** pathogenic nanoparticles may be produced naturally by toxic elements associated with air pollution that affect pasture forages or crops,uninte ntionally by reactions of these elements in protein-mineral mixes in dietary rations,or endogenously within tissues of fetuses and adult *** nanoparticles may form niduses in small vessels and predispose animals to a host of secondary opportunistic diseases affecting the reproductive,respiratory and gastrointestinal tracts of *** newly recognized abiotic pathogenic micro and nanoparticles are associated with *** discovery of the pathogenic nanoparticles led to the identification of nitrate,ammonium,and sulfur,in the form of sulfate,that seemingly enable the formation of the pathogenic nanoparticles in embryonic and fetal tissues.

关键词： Fetal loss High-protein diet nitrate toxicity Sulfate toxicity Sulfur-oxidizing bacteria Pathogenic nanoparticle

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