检索结果-南通市图书馆

Hepatoprotective effects of nigella sativa seed extract against acetaminophen-induced oxidative stress

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical Medicine 2016年第3期9卷 217-222页

作者： Gareeballa Osman Adam Md.Mahbubur Rahman Sei-Jin Lee Gi-Beum Kim Hyung-Sub Kang Jin-Shang Kim Shang-Jin Kim Department of Veterinary Medicine and Surgery College of Veterinary Medicine.Sudan University of Science and Technology Department of Veterinary Pharmacology and Toxicology College of Veterinary Medicine.Chonbuk National University Korea Basic Science Institute Jeonju Center

Objective:To investigate the protective effects of nigella sativa seed extract(NSSE) against acetaminophen(APAP)-induced hepaloloxicity in TIB-73 cells and rats.Methods:Toxicity in TIB-73 cells was induced with 10 μmol/L APAP and the protective effects of NSSE were evaluated at 25.50.75,100 μg/mL.For in rim examination,a total of 30 rals were equally divided into five experimental groups:normal control(vehicle),APAP(800 mg/kg body weight single IP injection) as a hepatotoxic control,and three APAP and NS pretreated(2 weeks) groups(APAP+NSSE 100 mg:APAP+NSSE 300 mg and APAP+NSSK 900 mg/kg).Results:TIB-73 cell viability was drastically decreased by(49.0±l.9)%after the 10 μmol/L APAP treatment,which also increased reactive oxygen species production.Co-treatment with NSSE at 25.50.75,and 100 μg/mL significantly improved cell viability and suppressed reactive oxygen species generation.In viro the APAP induced alterations in blood lactate levels,pH,anionic gap,and ion levels(HCO_3^-,Mg^(2+) and K^+),which tended to normalize with the NSSE pretreatment.The NSSE also significantly decreased elevated serum levels of alanine aminotransferase,aspartate aminotransferase,lactate dehydrogenase,and alkaline phosphatase induced by APAP,which correlated with decreased levels of hepatic lipid peroxidation(nialondialdehyde),increased superoxide dismutase levels,and reduced glutathione concentrations.Improved hepatic histology was also found in the treatment groups other than APAP group.Conclusions:The in vitro and in vim findings of this study demonstrated that the NSSE has protective effects against APAP-induced hepalotoxicity and metabolic disturbances by improving antioxidant activities and suppressing both lipid peroxidation and ROS generation.

关键词： nigella sativa Acetaminophen Antioxidants Oxidative stress TIB-73 cells Rat

A review on therapeutic potential of nigella sativa:A miracle herb

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical Biomedicine 2013年第5期3卷 337-352页

作者： Aftab Ahmad Asif Husain Mohd Mujeeb Shah Alam Khan Abul Kalam Najmi Nasir Ali Siddique Zoheir A.Damanhouri Firoz Anwar Health Information Technology Department Jeddah Community CollegeKing Abdulaziz University Department of Pharmaceutical Chemistry Faculty of PharmacyHamdard University Department of Pharmacognosy Faculty of PharmacyHamdard University Oman Medical College Department of Pharmacology Faculty of PharmacyHamdard University Department of Pharmacognosy College of PharmacyKing Saud University Department of Pharmacology Faculty of MedicineKing Abdulaziz University Siddhartha Institute of Pharmacy

nigella sativa(N.sativa)(Family Ranunculaceae)is a widely used medicinal plant throughout the world.It is very popular in various traditional systems of medicine like Unani and Tibb,Ayurveda and Siddha.Seeds and oil have a long history of folklore usage in various systems of medicines and food.The seeds of N.saliva have been widely used in the treatment of different diseases and ailments.In Islamic literature,it is considered as one of the greatest forms of healing medicine.It has been recommended for using on regular basis in Tibb-e-Nabwi(Prophetic Medicine).It has been widely used as antihypertensive,liver tonics,diuretics,digestive,anti-diarrheal,appetite stimulant,analgesics,anti-bacterial and in skin disorders.Extensive studies on N.sativa have been carried out by various researchers and a wide spectrum of its pharmacological actions have been explored which may include antidiabetic,anticancer,immunomodulator,analgesic,antimicrobial,anti-inflammatory,spasmolytic,bronchodilator,hepato-protective,renal protective,gaslro-prolective,antioxidant properties,etc.Due to its miraculous power of healing,N.sativa has got the place among the top ranked evidence based herbal medicines.This is also revealed that most of the therapeutic,properties of this plant are due to the presence of thymoquinone which is major bioactive component of the essential oil.The present review is an effort to provide a detailed survey of the literature on scientific researches of pharmacognostical characteristics,chemical composition and pharmacological activities of the seeds of this plant.

关键词： nigella sativa Miracle herb Ranunculaceae Habat-ul-Sauda Thymoquinone Tibb-e-Nabwi Black seeds Anti-diabetic Antioxidant

Amelioration of paracetamol hepatotoxicity and oxidative stress on mice liver with silymarin and nigella sativa extract supplements

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical Biomedicine 2015年第7期5卷 515-524页

作者： Reham Zakaria Hamza Mohammad Salem Al-Harbi Zoology Department Faculty of Science Zagazig University Biology Department Faculty of Science Taif University

Objective: To evaluate the ameliorator property of silymarin or/and nigella sativa(N. sativa) extract against N-acetyl-p-aminophenol(APAP)-induced injury in male mice at the biochemical, histological and ultrastructural levels.Methods: The mice were divided into seven groups(10/group). The first group was served as control. While, the second group was treated with dose of APAP. The third and fourth groups were treated with silymarin alone and N. sativa extract alone respectively. The fifth and sixth groups were treated with combination of APAP with silymarin and APAP with N. sativa extract respectively. The seventh group was treated with combination of both ameliorative compounds(silymarin and N. sativa extract) with APAP and all animals were treated for a period of 30 days. Results: Exposure to APAP at the treated dose to mice led to an alteration of liver functions, increased the alanine transaminase, aspartate aminotransferase and lactate dehydrogenase levels, decreased total protein level as well as the increasing the superoxide dismutase and malondialdehyde while decreased catalase, glutathione peroxidase and glutathione reduced activities. The effects of APAP on the biochemical parameters of mice were dose-dependent. Administration of silymarin or/and N. sativa extract to APAP-treated mice attenuates the toxicity of this compound, objectified by biochemical, histological and ultrastructural improvement of liver. But the alleviation was more pronounced with the both antioxidants. Conclusions: The synergistic effect of silymarin and N. sativa extract is the most powerful in reducing the toxicity induced by APAP and improving the liver functions and antioxidant capacities of mice.

关键词： Paracetamol Silymarin nigella sativa extract Liver function

Effects of nigella sativa on outcome of hepatitis C in Egypt

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2013年第16期19卷 2529-2536页

作者： Eman Mahmoud Fathy Barakat Lamia Mohamed El Wakeel Radwa Samir Hagag Department of Tropical Medicine Faculty of Medicine Ain Shams University Department of Clinical Pharmacy Faculty of Pharmacy Ain Shams University Department of Clinical Pharmacy Faculty of Pharmacy Egyptian Russian University

AIM: To evaluate the safety, efficacy and tolerability of nigella sativa (N. sativa ) in patients with hepatitis C not eligible for interferon (IFN)-α. METHODS: Thirty patients with hepatitis C virus (HCV) infection, who were not eligible for IFN/ribavirin therapy, were included in the present study. Inclusion criteria included: patients with HCV with or without cirrhosis, who had a contraindication to IFN-α therapy, or had refused or had a financial constraint to IFN-α therapy. Exclusion criteria included: patients on IFN-α therapy, infection with hepatitis B or hepatitis Ⅰ virus, hepatocellular carcinoma, other malignancies, major severe illness, or treatment non-compliance. Various parameters, including clinical parameters, complete blood count, liver function, renal function, plasma glucose, total antioxidant capacity (TAC), and polymerase chain reaction, were all assessed at baseline and at the end of the study. Clinical assessment included: hepato and/ or splenomegaly, jaundice, palmar erythema, flapping tremors, spider naevi, lower-limb edema, and ascites. N. sativa was administered for three successive months at a dose of (450 mg three times daily). Clinical response and incidence of adverse drug reactions were assessed initially, periodically, and at the end of the study. RESULTS: N. sativa administration significantly improved HCV viral load (380808.7 ± 610937 vs 147028.2 ± 475225.6, P = 0.001) and TAC (1.35 ± 0.5 vs 1.612 ± 0.56, P = 0.001). After N. sativa administration, the following laboratory parameters improved: total protein (7.1 ± 0.7 vs 7.5 ± 0.8, P = 0.001), albumin (3.5 ± 0.87 vs 3.69 ± 0.91, P = 0.008), red blood cell count (4.13 ± 0.9 vs 4.3 ± 0.9, P = 0.001), and platelet count (167.7 ± 91.2 vs 198.5 ± 103, P = 0.004). Fasting blood glucose (104.03 ± 43.42 vs 92.1 ± 31.34, P = 0.001) and postprandial blood glucose (143.67 ± 72.56 vs 112.1 ± 42.9, P = 0.001) were significantly decreased in both diabetic and non-diabetic HCV patients. Patients with lower-limb edema decreased significantly f

关键词： Hepatitis C virus nigella sativa Oxidative stress Viral load

Effects of nigella sativaSeed Extract on Perphenzine-Induced Muscle Rigidity in Male Mice

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Neuroscience 2014年第4期4卷 313-318页

作者： Mahsa Hadipour Jahromy Mokhtar Jalili Ahmad Jamshidi Mohajer Fatemeh Kamali Poor Shirin Mansoori Dara Medical Sciences Research Centre Tehran Medical Sciences Branch Islamic Azad University Tehran Iran Medical Student Tehran Medical Sciences Branch Islamic Azad University Tehran Iran Tehran Medical Sciences Branch Islamic Azad University Tehran Iran

Parkinson’s disease (PD) is a degenerative disorder of the central nervous system. Early in the course of the disease, the most obvious symptoms are movement-related, including: shaking, rigidity, slowness of movement and difficulty with walking and gait. Rigidity is stiffness and resistance to limb movement caused by increased muscle tone, an excessive and continuous contraction of muscles. Effects of different herbal preparations have been evaluated on muscle rigidity so far and some of them are approved in clinic. In the present research, the effects of nigella sativa hydroalcoholic seed extract on muscle stiffness in perphenazine-induced muscle rigidity were evaluated in adult male mice. In this experimental study, L-dopa 10 mg/kg, nigella sativa hydroalcoholic seed extract at 50, 100, and 200 mg/kg were administered orally to male Balb/c mice for 12 days. Control group only received water. Muscle rigidity scores were then measured and compared. The muscle rigidity score in group receiving extract at 50 mg/kg had no significant difference with control group but at 100 mg/kg it had been significantly improved starting at the 40th minute. The extract at 200 mg/kg had significant difference in all times measured in comparison with control group that also showed lower scores compared to L-dopa treated group. According to the obtained results in this study, it can be concluded that nigella sativa hydroalcoholic extract has good effects on muscle rigidity in dose-dependent pattern.

关键词： nigella sativa Parkinson Muscle Rigidity

Green Synthesis of Silver Nanoparticles Using nigella sativaSeeds and Evaluation of Their Antibacterial Activity

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advances in Nanoparticles 2020年第2期9卷 41-48页

作者： Marvit Osman Widdatallah Alaa Abdulmoneim Mohamed Ayat Ahmed Alrasheid Hiba Abbas Widatallah Layla Fathi Yassin Sahar Hussein Eltilib Shimaa Abdel Rahman Ahmed

Synthesis of silver nanoparticles using seeds of nigella sativa as a capping agent was evaluated in this study. Different concentrations of the aqueous extract of N. sativa with silver nitrate solution were exposed to sunlight;as a force for acceleration of the formulation. Then the silver nanoparticles were characterized by UV-Vis, scanning electron microscope (SEM) and X-ray diffraction (XRD) techniques. Antibacterial activity of the nanoparticles was investigated against Staphylococcus aureus and Escherichia coli by the disc diffusion method. The characterization of nanoparticles was detected by the change in color to yellow-brown which indicated the formulation of silver nanoparticles. Irregular shapes within range of nanoscale were detected using SEM and XRD techniques. The finding suggests that silver nanoparticles may be effectively used as antibacterial agent.

关键词： Silver Nanoparticles nigella sativa UV-Vis SEM XRD Antibacterial Activity

Effects of nigella sativaL. Seed Extract on Fatigue, Blood Biochemical Parameters and Thyroid Function in Male Mice

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Medicine 2014年第1期5卷 16-21页

作者： Azadeh Shariatifar Mahdieh Riazi Mona Ebnolelm Mahsa Hadipour Jahromy Department of Pharmacology Medical Sciences Research Center Tehran Medical Sciences Branch Islamic Azad University Tehran Iran

nigella sativa L. (Black seed), is a traditional herbal medicine that has been used for many purposes. The present study was designed to investigate the effects of hydro-alcoholic extract of nigella sativa L. (NS) on performance of Forced Swimming Test (FST), blood biochemical parameters related to fatigue and thyroid functions. Therefore, Blood Urea Nitrogen (BUN), Creatine Kinase (CK), Lactic Dehydrogenase (LDH), and Total Protein (TP), triiodothyronine T3, thyroxin T4 and TSH tests were investigated. Thirty five male adult mice were randomly divided into five groups: three NS-fed groups, one fluoxetine treated group and one control group. Three NS experimental groups received hydro-alcoholic extract of NS at doses of 50, 100 and 200 mg/kg orally for two weeks. Immobility time decreased in all NS groups compared with control group. Administration of NS significantly increased the concentration of T3 and T4 of the treatment groups. On the contrary, the amount of BUN, CK, LDH, TP and TSH decreased. In conclusion, black seed extract at the experimented doses showed anti-depressant, anti-fatigue and hyperthyroid effects.

关键词： nigella sativa Hydro-Alcoholic Extract Black Seed Thyroid Functions Forced Swimming Test Blood Biochemical Parameters Related to Fatigue

Ethanolic Extract of nigella sativaSeeds Lacks the Chemopreventive Efficacy in the Post Initiation Phase of DMH-Induced Colon Cancer in a Rat Model

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Pharmacology & Pharmacy 2013年第2期4卷 222-230页

作者： Wasfi Asfour Sawsan Almadi Lina Haffar Department of Histopathology College of Medicine Damascus University Damascus Syria. Department of Pharmacology and Toxicology College of Pharmacy Damascus University Damascus Syria

nigella sativa, belonging to the Ranunculacea family, is a versatile phytochemical mine bestowed with multi-dimensional medicinal effects. The current study was performed to investigate the chemopreventive efficacy, if any, of the ethanolic extract of indigenous nigella sativa seeds (ENS) and to evaluate its potentials on tumor progression during the initiation and post initiation phases of Dimethylhydrazine-induced colon carcinogenesis in a rat model. ENS treatment during the initiation phase unveiled chemopreventive effect manifested by significant reductions in tumor incidence, multiplicity and tumor volumes. Histopathological findings and modified Duke’s classification of tumors provided evidence that ENS, administered in the initiation phase, is capable of delaying progression, restricting invasion and attenuating aggressiveness of colon tumors. These results imply that ENS may be a promising candidate in the primary prevention of colon cancer. On the contrary, we demonstrated that ENS lacked chemopreventive and tumorigenesis inhibitory effects in the post initiation phase. We speculate that the chemopreventive effect of ENS might be due to the synergistic actions of various constituents present in the extract. However, extensive studies are warranted and more efforts need to be dedicated to fractionate, analyze and to further appraise the anticancer effect of ENS before any definitive conclusions can be drawn.

关键词： Lack Ethanolic Extract nigella sativa Dimethylhydrazine Post Initiation Colon Cancer Rat Modified Duke’s Classification

Therapeutic Trials of nigella sativa

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Pharmacy and Pharmacology 2019年第11期7卷 564-577页

作者： Aysenur Koc Nazan Guven S1d1ka Buyukhelvac1gil Ozturk1 Burcak Deniz Dedeoglu Hale Feyza Buyukhelvacigil Ramazan Buyukhelvac1gil Beril Koparal Zade Vital■ Natural Supplements Istanbul 34775 Turkey Zade Vital■ Natural Supplements 2800 Lively Blvd Elk Grove Village IL 60007 Illinois USA

nigella sativa (NS)(Ranunculaceae family) is generally utilized as a therapeutic plant all over the world. The seeds of the plant have a long history of use in different frameworks of medicines and food. N. sativa seeds reveal a broad spectrum of pharmacological activities including immunopotentiation and antihistaminic, antiseptic, antiallergic, anti-hypertensive, anti-inflammatory, and antimicrobial activities. It is known as a source of thymoquinone (TQ), thymohydroquinone, dithymoquinone, p-cymene, carvacrol, 4-terpineol, t-anethol, sesquiterpene longifolene, nigellicimine and nigellicimine-N-oxide,α-pinene and thymol etc. Additionally, this is uncovered that the majority of therapeutic properties of this plant are due to the presence of thymoquinone which is a major bioactive component of the essential oil. The incalculable medicinal properties and therapeutic uses of N. sativa prove its importance as a valuable medicinal plant. The aim of this review is to summarize some important pharmacological studies and phytochemical investigations on N. sativa and isolated principles which can be investigated further to get novel molecules in the search of novel herbal drugs.

关键词： nigella sativa medicinal plant phytoconstituent pharmacological activity