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Single-cell RNA sequencing in cornea research:Insights into limbal stem cells and their niche regulation

World Journal of Stem Cells 2023年第5期15卷 466-475页

作者： Di Sun Wei-Yun Shi Sheng-Qian Dou State Key Laboratory Cultivation Base Shandong Provincial Key Laboratory of OphthalmologyEye Institute of Shandong First Medical UniversityQingdao 266000Shandong ProvinceChina Qingdao Eye Hospital of Shandong First Medical University Qingdao 266000Shandong ProvinceChina Eye Hospital of Shandong First Medical University Jinan 250000Shandong ProvinceChina School of Ophthalmology Shandong First Medical UniversityQingdao 266000Shandong ProvinceChina

The corneal epithelium is composed of stratified squamous epithelial cells on the outer surface of the eye,which acts as a protective barrier and is critical for clear and stable *** continuous renewal or wound healing depends on the proliferation and differentiation of limbal stem cells(LSCs),a cell population that resides at the limbus in a highly regulated *** of LSCs or their niche can cause limbal stem cell deficiency,a disease that is manifested by failed epithelial wound healing or even ***,compared to stem cells in other tissues,little is known about the LSCs and their *** the advent of single-cell RNA sequencing,our understanding of LSC characteristics and their microenvironment has grown *** this review,we summarized the current findings from single-cell studies in the field of cornea research and focused on important advancements driven by this technology,including the heterogeneity of the LSC population,novel LSC markers and regulation of the LSC niche,which will provide a reference for clinical issues such as corneal epithelial wound healing,ocular surface reconstruction and interventions for related diseases.

关键词： Cornea Limbal stem cells Single cell RNA sequencing Heterogeneity Novel markers niche regulation

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