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Effects of niaoduqing Particles(尿毒清颗粒)on Delaying Progression of Renal Dysfunction:A Post-trial,Open-Label,Follow-up Study

引用

Chinese Journal of Integrative Medicine 2019年第3期25卷 168-174页

作者： ZHENG Ying WANG Nian-song LIU Yu-ning HE Li-qun JIAN Gui-hua LIU Xu-sheng NI Zhao-hui CHENG Xiao-hong LIN Hong-li ZHOU Wen-hua WANG Ya-ping FANG Jing-ai HE Ya-ni YANG Hong-tao ZHAO Li-juan DING Han-lu WANG Li-hua YU Ren-huan LI Wen-ge YE Zhi-ming GUO Wang ZHAN Yong-li MAO Hui-juan HU Zhao YAO Chen CAI Guang-yan CHEN Xiang-mei Department of Nephrology Chinese People's Liberation Army General Hospital Chinese People's Liberation Army Institute of Nephrology State Key Laboratory of Kidney Diseases (2011DAV00088) National Clinical Research Center for Kidney Diseases Department of Nephrology and Rheumatology Affiliated Sixth People's Hospital Shanghai Jiaotong University Department of Nephrology Dongzhimen Hospital The First Affiliated Hospital of Beijing University of Chinese Medicine Department of Nephrology Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine Department of Nephrology Guangdong Provincial Hospital of Chinese Medicine Department of Nephrology Renji Hospital Shanghai Jiaotong University Department of Nephrology Shaanxi Traditional Chinese Medicine Hospital Department of Nephrology First Affiliated Hospital of Dalian Medical University Department of Nephrology Second Hospital of Jilin University Department of Nephrology Army General Hospital Department of Nephrology First Affiliated Hospital of Shanxi Medical University Department of Nephrology Daping Hospital Army Medical University Department of Nephrology First Teaching Hospital of Tianjin University of Traditional Chinese Medicine Department of Nephrology Xijing Hospital Air Force Medical University Department of Nephrology University of Electronic Science and Technology Sichuan Academy of Sciences and Sichuan Provincial People's Hospital Department of Nephrology Second Affiliated Hospital of Shanxi Medical University Department of Nephrology Xiyuan Hospital China Academy of Chinese Medical Sciences Department of Nephrology China-Japan Friendship Hospital Department of Nephrology Guangdong General Hospital Guangdong Academy of Medical Sciences Department of Nephrology Beijing Friendship Hospital Capital Medical University Department of Nephrology Guang'anmen Hospital of China Academy of Traditional Chinese Medical Sciences Department of Nephrology Jiangsu Province Hospital First Affiliated Hospital of Nan

Objective: To follow up the participants of the randomized clinical trial "Efficacy and Safety of niaoduqing Particles(尿毒清颗粒) for Delaying Moderate-to-Severe Renal Dysfunction", and assess the long-term effects of niaoduqing Particles on delaying the progression of renal dysfunction. Methods: Participants, who had previously been randomly assigned to receive niaoduqing Particles or placebo for 24 weeks(146 cases in each group), were invited to follow-up and all were administered niaoduqing Particles 5 g thrice daily and 10 g before bedtime for 24 weeks. The primary endpoints were changes in baseline serum creatinine(Scr) and estimated glomerular filtration rate(e GFR) after completion of the open-label treatment period. Results: After the double-blind period, the median(interquartile range) changes in Scr were 1.1(–13.0–24.1) and 11.7(–2.6–42.9) μmol/L for the niaoduqing Particle and placebo groups, respectively(P=0.008), and the median changes in e GFRs were –0.2(–4.3–2.7) and –2.21(–5.7–0.8) mL·min^(-1)·1.73 m^(-2), respectively(P=0.016). There were significant differences in the double-blind period changes in renal function between groups. After the open-label period, the median changes in Scr were 9.0(–10.0–41.9) and 17.5(–6.0–50.0) μmol/L for the niaoduqing Particle and placebo groups according to baseline grouping, respectively(P=0.214), and the median changes in eGFRs were –2.3(–6.4–1.9) and –3.7(–7.5–1.1) mL·min^(-1)·1.73 m^(-2), respectively(P=0.134). There were no statistical differences in the open-label period changes in renal function between groups. The eGFR reduction of participants who accepted niaoduqing Particle treatment for 48 weeks was projected to 2.5 m L·min^(-1)·1.73 m(-2) per year. Conclusions: niaoduqing Particles appear to have long-term efficacy for patients with moderate-to-severe renal dysfunction. Although there was no statistical difference, the early use of niaoduqing Paticles seems to ameliorate the worsening of renal function.

关键词： chronic kidney disease moderate-to-severe renal dysfunction niaoduqing Particles post-trial follow-up Chinese medicine

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Clinical　evaluation　of　herbal　extract　niaoduqing　in　the　treatmentofearly　stage　chronic　renal　failure

引用

Journal of Medical Colleges of PLA(China) 1996年第4期11卷 278-280页

作者：刘俊潘振邦

in the advanced stage of kidney diseases,the functional capacity of the diseased kidney gradually declines , and develops into uremia. There is no medicine to retard the progression of early stage chronic renal failure to end-stage renal failure. For this reason, a clinical study was performed in two groups of patients with early stage chronic renal failure. Group 1 patients (400 cases) were treated with a herbal preparation, niaoduqing,and group 2 patients (160 cases) received therapy with Oxyamyli Tectus Sldehydum. It was found that both blood urea nitrogen (BUN) and serum creatinine (Scr) levels decreased in group 1 patients (P0. 05).According to theory of traditional Chinese medicine , niaoduqing can clear BUN and Scr . ameliorate uremic symptoms and protect the residual renal function. From the study, it is suggested that this herbal mixture can be used to treat patients with moderate renal failure. Furthermore , the mixture can be conveniently taken orally and has no side effects.

关键词： chronic renal failure Chinese drugs herbal extract niaoduqing

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