检索结果-南通市图书馆

Effects of medium chain triglycerides on hepatic fatty acid oxidation in clofibrate-fed newborn piglets

Animal Nutrition 2023年第1期12卷 334-344页

作者： Jinan Zhao Brandon Pike Jin Huang Zhihua Feng Jack Odle Xi Lin Laboratory of Developmental Nutrition Department of Animal SciencesNorth Carolina State UniversityRaleighNC 27695USA Zinpro Corporation Eden PrairieMN 55344USA College of Biological Engineering Henan University of TechnologyZhengzhou450001China College of Animal Science and Technology Agricultural University of HebeiBaoding071001China

To investigate whether increasing tricarboxylic acid(TCA)cycle activity and ketogenic capacity would augment fatty acid(FA)oxidation induced by the peroxisome proliferator-activated receptor-alpha(PPARα)agonist clofibrate,suckling newborn piglets(n=54)were assigned to 8 groups following a 2(±clofibrate)×4(glycerol succinate[SUC],triglycerides of 2-methylpentanoic acid[T2M],valeric acid[TC5]and hexanoic acid[TC6])factorial *** group was fed an isocaloric milk formula containing either 0%or 0.35%clofibrate(wt/wt,dry matter basis)with 5%SUC,T2M,TC5 or TC6 for 5 *** 6 pigs served as newborn *** acid oxidation was examined in fresh homogenates of liver collected on d 6 using[1-^(14)C]palmitic acid(1 mM)as a substrate(0.265μCi/μmol).Measurements were performed in the absence or presence of L-carnitine(1 mM)or inhibitors of 3-hydroxy-3-methylglutaryl-CoA synthase(L659699,1.6μM)or acetoacetate-CoA deacylase(iodoacetamide,50μM).Without clofibrate stimulation,^(14)C accumulation in CO_(2) was higher from piglets fed diets containing T2M and TC5 than SUC,but similar to those fed *** clofibrate stimulation,accumulation also was higher in homogenates from piglets fed TC5 than all other dietary *** between clofibrate and carnitine or the inhibitors were observed(P=0.0004)for acid soluble products(ASP).In vitro addition of carnitine increased^(14)C-ASP(P<0.0001)above all other treatments,regardless of clofibrate *** percentage of^(14)C in CO_(2) was higher(P=0.0023)in TC5 than in the control *** these results we suggest that dietary supplementation of anaplerotic and ketogenic FA could impact FA oxidation and modify the metabolism of acetyl-CoA(product ofβ-oxidation)via alteration of TCA cycle activity,but the modification has no significant impact on the hepatic FA oxidative capacity induced by PPARα.In addition,the availability of carnitine is a critical element to maintain FA oxidation during the neonatal perio

关键词： PPARα Clofibrate newborn piglets Medium chain triglyceride(MCT) Hepatic fatty acid oxidation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Identification of villous M cells in the small intestine of newborn piglets

Identification of villous M cells in the small intestine of ...

引用

第十届全国免疫学学术大会

作者： Ren-Feng LI Yan-Yan YANG Song-Lin QIAO Jun-Qing GUO Gai-Ping ZHANG College of Veterinary Medicine Northwest A & F University College of Veterinary Medicine Henan Institute of Science and Technology Key Laboratory of Animal Immunology of the Ministry of Agriculture Henan Provincial Key Laboratory of Animal Immunology Henan Academy of Agricultural Sciences College of Animal Science and Veterinary Medicine Henan Agricultural University

0bjective:Microfold(M)cells,as an important part of intestinal mucosal immune system,act as antigen-sampling sites for initiating antigen specific mucosal immune responses,but they also provide a gateway for enteropathogen *** aim of this study was to determine the distribution characteristics and morphological ***:The distribution characteristics and morphological features of villous M in newborn piglets’small intestine were determined by immunohistochemical(IHC)and morphological ***:These villous M cells,with dark apical membrane,possessed markedly blunted and reduced numbers of microvilli,and had a slightly depressed surface compared to neighboring villous epithelial *** villous M cells in duodenum and mid-jejunum were mostly columnar in shape and the ileal villous M cells exhibited more pocket-like *** showed that the ileum had significantly increased number(Pnewborn piglets,with variable morphology and distribution pattern in the different regions of the small intestine.

关键词： Microfold Cells newborn piglets Immunohistochemical Morphological

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：