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Translocator protein 18 kDa(TSPO): old dogma, new mice, new structure, and new questions for neuroprotection

Neural Regeneration Research 2015年第6期10卷 878-880页

作者： Eun-Jung Kim Seong-Woon Yu Department of Brain and Cognitive Science Daegu Gyeongbuk Institute of Science and Technology (DGIST)

The normal development and optimal functioning of the brain requires a vigilant immune surveillance system to detect and remove potential risk factors and prevent infection and tissue damage. Microglia are the resident immune cells and the frontline defenders responsible for the immune response of the brain. Resting microglia possess a ramified morphology with numerous thin processes that continuously sample the environment. In response to inflammatory signals, microglia become activated and transform their morphology into a thick, amoeboid-like shape. Activated microglia proliferate, tolerate to sites of iniurv,

关键词： TSPO old dogma Translocator protein 18 kDa new mice new structure

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A new anchor-siphon drainage combined method used for slope stabilization

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Journal of Mountain Science 2023年第11期20卷 3295-3311页

作者： SUN Hong-yue WANG Xu YU Yang SHU Jun-wei WANG Tian-long LUO Rui CHU Zhao-wei Ocean College Zhejiang UniversityZhejiang ProvinceZhoushan 316021China College of Civil Engineering and Architecture Zhejiang UniversityHangzhou 310058China

A new anchor-siphon drainage combined method used for slope stabilization is proposed in this *** includes an anchoring section and a siphon drainage *** novelty of the anchor-siphon drainage combined method is the realization of the drainage and anchoring in the one inclined *** engineering cost of drilling and the resulting disturbance to the slope is *** validate the feasibility of the proposed method,a numerical method that combines the pore water pressure distribution after siphon drainage and the anchoring force of the anchoring section is used to evaluate the safety of the slope with the anchor-siphon drainage *** proposed method was illustrated and validated with the Hongpu Village landslide,in Tonglu County,Zhejiang Province,in *** with the common anchor bar with the same length in the anchoring section,the factor of safety(FOS)for Hongpu Village slope with anchorsiphon drainage is increased by *** calculation method of the optimal length ratio between the drainage section and the anchoring section and its influencing factors were *** the different design parameters,there is always an optimal length ratio of the drainage *** with the siphon drainage and full-length anchor bar with the same borehole length,the anchor-siphon drainage combined method shows better landslide prevention ***,when the optimized parameters with a bond strength of 560kPa,a borehole inclination of 35°,and no reduction in length are used,the calculated safety factor is 1.316,which is significantly higher than the FOS of 1.131 for the slope with siphon drainage.

关键词： Landslide Safety factor Optimized design Siphon drainage Anchor new structure

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情报学的坚守和发展创新

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图书馆学情报学 2021年第9期

作者：赖茂生

文章围绕情报学的坚守与发展创新主题，分析了情报学建立和发展的基础条件，学科面临的新环境新挑战，讨论了对学科发展现状的不同看法，阐述了当前学科发展中必须坚守的5个方面，提出有关学科创新发展的几点建议。

关键词：情报学新格局学科基础学科现状坚守与创新发展战略 Information science new structure Discipline basis Discipline status Preservation and innovation Development strategy

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