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Lymphocytopenia and neutrophilia Deteriorate at the Lowest Oxygenation Index Timepoint in COVID-19 Patient

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International Journal of Clinical Medicine 2020年第12期11卷 810-822页

作者： Yiwen Xu Weijun Hong Gang Wu Weiling Li Chunqiang Xu Xiaofei Hu Meixian Zhang Huihui Xu En Wang Shaofa Ke Xiaoping Jin Department of Neurology Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University Linhai China The First Clinical Medical College Wenzhou Medical University Wenzhou China Department of Pharmacy Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University Linhai China Public Experiment Center Medical Research Center Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University Linhai China Laboratory of Gynecologic Oncology Medical Research Center Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University Linhai China

Objective: Coronavirus disease 2019 (COVID-19) spread throughout the world and caused hundreds of thousands of infected people to death. However, the pathogenesis of severe acute respiratory syndrome coronavirus-2 (SARS COV-2) is poorly understood. The objective of this study is to retrospectively explore the pathogenesis of COVID-19 from clinical laboratory findings, taking disease progression into account. Methods: A single-centered, retrospective study was carried out, which included moderate (n = 76) and severe COVID-19 cases (n = 22). The difference of laboratory findings from blood routine examination and hepatorenal function test were retrospectively evaluated between the state of moderate and severe. The disease progression was indicated by oxygenation index. Results: Age is a risk factor for disease progression from moderate to severe. Lymphocytopenia, neutrophilia, liver and kidney function decreasement occurred in severe patients on admission, compared with moderate patients. Lymphocytopenia and neutrophilia deteriorated at the lowest oxygenation index timepoint in the severe patients. And the oxygenation index was associated with ratio of lymphocyte and neutrophil in COVID-19 patients. Conclusions: Lymphocytopenia and neutrophilia, which deteriorate in the progression of severe patients, are the main pathogenesis of COVID-19. More measures need to be taken to control lymphocytopenia and neutrophilia in severe COVID-19. Oxygenation index presented potentiality as predictor on the progression of COVID-19.

关键词： COVID-19 Oxygenation Index Lymphocytopenia neutrophilia Glucocorticoids

Eosinopenia is a predictive factor for the severity of acute ischemic stroke

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Neural Regeneration Research 2019年第10期14卷 1772-1779页

作者： Hui-Min Zhao Wen-Qian Qin Pei-Ji Wang Zhong-Min Wen Department of Neurology the Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Department of Orthopedics the Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina

Previous data have revealed an association between eosinopenia and mortality of acute ischemic ***,the relationship of eosinopenia with infarct volume,infection rate,and poor outcome of acute ischemic stroke is still *** retrospective study included 421 patients(273 males,65%;mean age,68.0± 13.0 years)with first acute ischemic stroke who were hospitalized in the Second Affiliated Hospital of Soochow University,China,from January 2017 to February *** data,neuroimaging results,and modified Rankin Scale scores were *** were divided into four groups according to their eosinophil percentage level(neutrophilia;the area under curve was 0.906 and 0.876,respectively;a large infarct was considered as that with a diameter larger than 3 cm and involving more than two major arterial blood supply *** regression analysis revealed that eosinophil percentage was an independent risk factor for acute ischemic stroke(P=0.002).Moreover,eosinophil percentage was significantly associated with large infarct volume,high infection rate(pulmonary and urinary tract infections),and poor outcome(modified Rankin Scale score>3)after adjusting for potential confounding factors(P-trend<0.001).These findings suggest that eosinopenia has the potential to predict the severity of acute ischemic *** study was approved by the Ethics Committee of the Second Affiliated Hospital of Soochow University,China(approval number:K10)on November 10,2015.

关键词： nerve regeneration eosinopenia eosinophil ischemia stroke infarct volume infection clinical outcome neutrophilia risk factors predictive factor neural regeneration

Persistent papules with adult-onset Still's disease:a case report

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International Journal of Dermatology and Venereology 2019年第1期2卷 53-55页

作者： Na-Na Zheng Xiao-Xiao Yang Jing-Xi Zhang Lian-Sheng Zhong Department of Dermatology Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu 221002China

Introduction Adult-onset Still's disease (AOSD) is a systemic infl ammatory disease with unknown *** is classically characterized by a high spiking fever,evanescent rash,liver dysfunction,leukocytosis with neutrophilia,generalized lymphadenopathy,and *** typical skin rash of AOSD is evanescent,appearing and disappearing along with the rise and fall of the ***,recent reports have highlighted atypical rashes associated with AOSD,such as persistent pruritic plaques and *** herein report a case of AOSD with persistent pruritic papules on the chest in a 47-year-old woman,who was suspected of septicemia and lymphoma for more than 3 weeks before diagnosis confirmed.

关键词： disappearing diagnosis neutrophilia

Predictors of Meningitis in Under-Fifteen Children Attending an Intensive Care Unit of an Urban Large Diarrheal Disease Hospital in Bangladesh

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Food and Nutrition Sciences 2014年第2期5卷 169-176页

作者： Farzana Afroze Tahmeed Ahmed Shafiqul Alam Sarker Abu S. G. Faruque Hasan Ashraf Pradip Kumar Bardhan Sumon Kumar Das Mohammod Jobayer Chisti Centre for Nutrition and Food Security (CNFS) International Centre for Diarrhoeal Disease Research Dhaka Bangladesh Centre for Nutrition and Food Security (CNFS) International Centre for Diarrhoeal Disease Research Dhaka Bangladesh School of Population Health The University of Queensland Brisbane Australia.

Background: Data are lack on predicting features of meningitis in diarrheal children although the great clinical importance. Objective: To evaluate clinical and laboratory features in predicting meningitis in under-fifteen children having diarrheal illnesses. Methods: Children aged 1 month to 15 years, admitted in the ICU of the Dhaka Hospital of icddr, b between March 2011 and February 2012 with fever and seizure or altered consciousness and having LP done were enrolled into this analysis. Those children who had abnormal CSF findings [pleocytosis (normal range of leukocyte, 0 - 10/mm3) and/or elevated protein (normal range, 0.10 - 0.45 mg/dl) and low glucose (normal value, 60% of corresponding blood glucose)] were defined as meningitis. Comparison was made between children with (cases = 17) and without meningitis (controls = 66) from our study children. Data were retrospectively collected from SHEBA, an online database system of the Dhaka Hospital of icddr, b. Results: Death was significantly higher among the cases compared to the controls (29% vs. 3%, p = 0.003). In logistic regression analysis, after adjusting for potential confounders, cases frequently had hypoxemia (95% CI 1.55 - 21.93), absent peripheral pulse (95% CI 1.95 - 27.13) and neutrophilia (95% CI 1.13 - 17.00). Conclusion: Our data suggest that children with meningitis had higher case fatality rate. Simple independent predictors of meningitis such as hypoxemia, absent peripheral pulse, and neutrophilia may help clinicians to initiate early and prompt management in order to curve lifelong sequel due to meningitis and death in such patient population especially those in resource poor settings.

关键词： Children Diarrhea Hypoxemia Meningitis neutrophilia Peripheral Pulse

Acute and Chronic Toxicity of Thioacteamide and Alterations in Blood Cell Indices in Rats

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Journal of Cancer Therapy 2013年第1期4卷 251-259页

作者： Muddasir Hassan Abbasi Tasleem Akhtar Ihtzaz A. Malik Sana Fatima Babar Khawar Khawaja Abdul Mujeeb Ghulam Mustafa Shabir Hussain Javaid Iqbal Nadeem Sheikh Cell and Molecular Biology Lab Department of Zoology University of the Punjab Lahore Pakistan Department of Anatomy Shaikh Zayed Postgraduate Medical Institute Shaikh Khalifa Bin Zayed Medical and Dental College Lahore Pakistan Department of Zoology Govt. College of Science Lahore Pakistan University of Health Sciences Lahore Pakistan

Background: Thioacetamide (TAA) has been used extensively in the development of suitable animal models of acute and chronic liver injury employing various doses, times and routes of its administration, particularly in drinking water due to its resemblance with human liver fibrosis and cirrhosis. The aim of this study was to investigate and compare hematological alteration during the acute and chronic liver inflammation. Methods: Acute Liver inflammation was induced in Wistar rats via intraperitoneal injection of thioacetamide and the animals were sacrificed 12 h after the TAA administration. Induction of chronic liver inflammation was performed by continuous administration of TAA in the drinking water (200 mg/L) during 18 weeks of experiment. After that all animals were sacrificed and Blood samples were collected for further analysis. Results: Single intra peritoneal injection of TAA (300 mg/kg B.W.) induced an acute condition with hematological changes including leukocytosis with marked neutrophilia (P = 0.0429), lymphopenia, thrombocytosis as well as increased hemoglobin concentration (P 0.05) and decline of erythrocytic count (P = 0.0009). Eighteen weeks of uninterrupted supply of TAA (200 mg/L) in drinking water lead to chronic inflammation and the hematological alterations were leucopenia (P = 0.0197) accompanied with neutropenia and thrombocytopenia. Increase in RBCs (P = 0.0073) and Hb contents was also observed with a decline of red cell indices. Conclusion: Taken together these findings we can conclude that the animals respond differently under acute and chronic inflammatory condition with TAA administration. Leukocytosis with marked neutrophilia, thrombocytosis as well as increased hemoglobin concentration and decline of erythrocytic count were observed in acute while leucopenia accompanied with neutropenia and thrombocytopenia and increase in RBCs, Hb and Hct was also observed with a decline of other red cell indices during chronic phase.

关键词： Haematology Inflammation Leucocytosis Leucopenia neutrophilia Neutropenia Thrombocytosis and Thrombocytopenia