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neutrophil-lymphocyte ratio predicts the prognosis of patients with hepatocellular carcinoma after liver transplantation

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World Journal of Gastroenterology 2013年第45期19卷 8398-8407页

作者： Guang-Qin Xiao Chang Liu Da-Li Liu Jia-Yin Yang Lu-Nan Yan Department of Liver and Vascular Surgery West China Hospital of Sichuan University

AIM:To determine whether an elevated neutrophillymphocyte ratio(NLR)is negatively associated with tumor recurrence in patients with hepatitis B virus(HBV)-related hepatocellular carcinoma(HCC)after liver transplantation(LT),and to determine the optimal predictive NLR cut-off ***:The data of HCC patients who had undergone LT came from the China Liver Transplant Registry *** collected data from 326 liver cancer patients who had undergone LT at our medical *** divided the patients into groups based on their NLRs(3,4 or 5).We then compared the clinicopathological data and long-time survival between these ***,we used receiver operating characteristic analysis to determine the optimal NLR ***:Of 280 HCC patients included in this study,263 were HBV *** with an NLR<3 and patients with an NLR≥3 but<4 showed no significant differences in overall survival(OS)(P=0.212)or disease-free survival(DFS)(P=0.601).Patients with an NLR≥4 but<5 and patients with an NLR≥5also showed no significant differences in OS(P=0.208)or DFS(P=0.618).The 1-,3-and 5-year OS rates of patients with an NLR<4 vs an NLR≥4 were 87.8%,63.8%and 61.5%vs 73.9%,36.7%and 30.3%,respectively(P<0.001).The 1-,3-and 5-year DFS rates of patients with an NLR<4 vs NLR≥4 were 83.9%,62.9%and 60.7%vs 64.9%,30.1%and 30.1%,respectively(P<0.001).Univariate and multivariate analyses demonstrated that three factors,including NLR≥4(P=0.002),were significant predictors of tumor recurrence in HCC patients after ***:A preoperative elevated NLR significantly increased the risk for tumor recurrence in HCC patients after LT.

关键词： Hepatocellular carcinoma Liver transplantation Inflammatory reaction neutrophil-lymphocyte ratio Hepatitis B virus

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neutrophil-lymphocyte ratio:A prognostic tool in patients with inhospital cardiac arrest

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World Journal of Critical Care Medicine 2019年第2期8卷 9-17页

作者： Vishal H Patel Philip Vendittelli Rajat Garg Susan Szpunar Thomas LaLonde John Lee Howard Rosman Rajendra H Mehta Hussein Othman Department of Cardiovascular Medicine Ascension-St John Hospital and Medical Center Department of Internal Medicine Cleveland Clinic Department of Biomedical Investigations and Research Ascension-St John Hospital and Medical Center Department of Critical Care Medicine Ascension-St John Hospital and Medical Center Duke Clinical Research Institute Duke University Medical Center

BACKGROUND In-hospital cardiac arrest(IHCA) portends a poor prognosis and survival to discharge rate. Prognostic markers such as interleukin-6, S-100 protein and high sensitivity C reactive protein have been studied as predictors of adverse outcomes after return of spontaneous circulation(ROSC); however; these variables are not routine laboratory tests and incur additional cost making them difficult to incorporate and less attractive in assessing patient's prognosis. The neutrophil-lymphocyte ratio(NLR) is a marker of adverse prognosis for many cardiovascular conditions and certain types of cancers and sepsis. We hypothesize that an elevated NLR is associated with poor outcomes including mortality at discharge in patients with *** To determine the prognostic significance of NLR in patients suffering IHCA who achieve *** A retrospective study was performed on all patients who had IHCA with the advanced cardiac life support protocol administered in a large urban community United States hospital over a one-year period. Patients were divided into two groups based on their NLR value(NLR < 4.5 or NLR ≥ 4.5). This cutpoint was derived from receiving operator characteristic curve analysis(area under the curve = 0.66) and provided 73% positive predictive value, 82% sensitivity and42% specificity for predicting in-hospital death after IHCA. The primary outcome was death or discharge at 30 d, whichever came *** We reviewed 153 patients with a mean age of 66.1 ± 16.3 years; 48% were ***-hospital mortality occurred in 65%. The median NLR in survivors was 4.9(range 0.6-46.5) compared with 8.9(0.28-96) in non-survivors(P = 0.001). A multivariable logistic regression model demonstrated that an NLR above 4.55[odds ratio(OR) = 5.20, confidence interval(CI): 1.5-18.3, P = 0.01], older age(OR= 1.03, CI: 1.00-1.07, P = 0.05), and elevated serum lactate level(OR = 1.20, CI:1.03-1.40, P = 0.02) were independent predictors of *** An NLR ≥ 4.5 may

关键词： neutrophil-lymphocyte ratio In-hospital cardiac arrest Prognosis Lactate Asystole Ventricular fibrillation Pulseless electrical alternans Pulseless ventricular tachycardia

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neutrophil-lymphocyte ratio in the management and prediction of outcomes in renal cell carcinoma

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World Journal of Clinical Urology 2018年第1期7卷 1-6页

作者： Tuck Y Yong Kareeann SF Khow Internal Medicine Flinders Private Hospital Geriatric Training Research and Aged Care Centre the University of Adelaide

Renal cell carcinoma(RCC) is one of the ten most common *** prognosis of RCC is poor when the disease is in advanced stages,with five-year survival of less than 10%.However current assessment approaches are limited in their ability to prognosticate and guide therapeutic ***-mediated inflammatory response is increasingly being recognised to have an important role in carcinogenesis of *** inflammatory markers have been found to identify patients with RCC at high risk of recurrence and predict ***-lymphocyte ratio(NLR) is a simple and inexpensive inflammatory marker that has been shown to be of value in the assessment of patients with *** elevated pretreatment NLR has been found to be associated with reduced overall survival,recurrence-free survival and progress-free survival and risk of recurrence in localized *** addition,lower pretreatment NLR has been demonstrated to be associated with better clinical response to systemic therapy including vascular endothelial growth factor inhibitors,among patients with metastatic ***,NLR has not been found to differentiate whether small renal masses of less than 40 mm are benign or *** research is needed to determine the cut-offs for NLR to predict different clinical outcomes and how post-treatment NLR can be *** addition,more work is also needed to evaluate combining NLR with other biomarkers in a model to predict patients' clinical outcome or response to treatment for RCC.

关键词： neutrophil-lymphocyte ratio Prognosis Renal cell carcinoma Survival

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neutrophil-lymphocyte Ratio as a Prognostic Factor in Incurable Stage IV Colorectal Cancer

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Open Journal of Gastroenterology 2018年第2期8卷 45-56页

作者： Shinya Munakata Kiichi Sugimoto Kumpei Honjo Masaya Kawai Shingo Kawano Hirohiko Kamiyama Masakazu Ouchi Makoto Takahashi Yuichi Tomiki Kazuhiro Sakamoto Department of Coloproctological Surgery Juntendo University Faculty of Medicine Tokyo Japan

Objectives: Our aim is investigating the predictive potential of these available and convenient laboratory dates in stage IV colorectal cancer (CRC) patients. Methods: We identified the cases of 114 consecutive patients who underwent the surgery at our Hospital between January 2006 and December 2012 by using the multivariate analysis, the Cox proportional-hazard regression model. Results: Multivariate analysis for the predictors of survival showed metastatic lesion resection [hazard ratio (HR) = 3.2, 95% confidence interval (CI) 1.6 - 6.6;p = 0.007] and only primary lesion resection (HR = 1.9, 95% CI 1.1 - 4.0;p = 0.045) remained independently significant prognostic factors. Therefore, we divided in 3 groups, 1) metastatic lesion resection group with primary lesion resection (n = 52 in the Met/Prim lesion group), 2) primary lesion resection without metastatic lesion resection (n = 38 in the Primary lesion group) and 3) palliative operation (n = 24 in the Palliative group). Age was the only independent risk factor in the Met/Prim lesion group. In the Primary lesion group, neutrophil lymphocyte ratio (NLR) > 5, elevated Alanine aminotransferase and patients without chemotherapy were correlated with poor survival. In the Palliative group, NLR > 5 and patients who could not be treated with chemotherapy remained independent predictors of worse survival. Conclusions: NLR is not only simple and convenient for classification of patients, but also one of the important predictors of mortality for stage IV incurable CRC patients.

关键词： Colorectal Cancer neutrophil-lymphocyte Ratio Surgery Prognosis Metastasis

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Systemic Immune-Inflammation Index (SII) and neutrophil-lymphocyte Ratio (NLR) as Systemic Inflammatory Predictors in the Diagnosis of Bullous Pemphigoid and Pemphigus Vulgaris

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Journal of Cosmetics, Dermatological Sciences and Applications 2024年第2期14卷 211-225页

作者： Mulubwa Changa Chibesa Mengqi Guan Shanshan Li Department of Dermatology and Venerology First Hospital of Jilin University Changchun China

Introduction: Autoimmune blistering skin disorders such as Bullous Pemphigoid and Pemphigus Vulgaris present diagnostic challenges. The Systemic Immune-Inflammation Index (SII) and neutrophil-lymphocyte Ratio (NLR), are inflammatory markers used to assess the body’s immune-inflammatory response. Objectives: The study aims to evaluate the significance of hematologic markers, specifically the Systemic Immune-Inflammation Index (SII) and neutrophil-lymphocyte Ratio (NLR), as diagnostic predictors of bullous pemphigoid (BP) and pemphigus vulgaris (PV). Methods: A retrospective study of 64 patients (36 with BP and 28 with PV). Patient clinical data: age, gender, complete blood count, autoimmune antibody levels (Dsg1, 3 and BP180, 230), IgE and C-reactive protein, and history of hypertension, diabetes, brain infarction, and coronary heart disease. The data was analyzed using SPSS. Results: The study involved 36 (56.3%) diagnosed with bullous pemphigoid (BP) and 28 (43.75%) with pemphigus vulgaris (PV). The average age in BP was 71 ± 8 and 52 ± 13 in PV. Laboratory findings showed high levels of Dsg1, Dsg3, neutrophil count, and lymphocyte count in PV, while high levels of eosinophils with a significant increase in C-reactive protein (CRP) in BP. Blood biomarkers, including NLR, PLR, SII, MPV, CRP, and IgE, proved an overall of 84.4% in disease prediction. Dsg1, Dsg3, BP180, and BP230 showed an overall of 88.1%. No significant relationship was noted between NLR, SII, and patients with comorbidities. Conclusion: The study highlights the diagnostic potential of SII and NLR in addition to hematologic markers in BP and PV, emphasizing their role in early diagnosis and therapeutic interventions, requiring further validation in larger patient cohorts.

关键词： Pemphigoid Vulgaris neutrophil-lymphocyte Immune-Inflammation Autoimmune

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Activated systemic inflammatory response at diagnosis reduces lymph node count in colonic carcinoma

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World Journal of Gastrointestinal Oncology 2016年第8期8卷 623-628页

作者： Rory P Kennelly Brenda Murphy John O Larkin Brian J Mehigan Paul H McCormick Department of Colorectal Surgery St James Hospital

AIM: To investigate a link between lymph node yield and systemic inflammatory response in colon cancer. METHODS: A prospectively maintained database was interrogated. All patients undergoing curative colonic resection were included. neutrophil lymphocyte ratio(NLR) and albumin were used as markers of SIR. In keeping with previously studies, NLR ≥ 4, albumin < 35 was used as cut off points for SIR. Statistical analysis was performed using 2 sample t-test and χ~2 tests where ***: Three hundred and two patients were included for analysis. One hundred and ninety-five patients had NLR < 4 and 107 had NLR ≥ 4. There was no difference in age or sex between groups. Patients with NLR of ≥ 4 had lower mean lymph node yields than patients with NLR < 4 [17.6 ± 7.1 vs 19.2 ± 7.9(P = 0.036)]. More patients with an elevated NLR had node positive disease and an increased lymph node ratio(≥ 0.25, P = 0.044). CONCLUSION: Prognosis in colon cancer is intimately linked to the patient’s immune response. Assuming standardised surgical technique and sub specialty pathology, lymph node count is reduced when systemic inflammatory response is activated.

关键词： Systemic inflammatory response Lymph node yield Lymph node count Colon cancer Colonic cancer neutrophil-lymphocyte ratio neutrophil to lymphocyte ratio Lymph node ratio

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Novel immunological and nutritional-based prognostic index for gastric cancer

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World Journal of Gastroenterology 2015年第19期21卷 5961-5971页

作者： Kai-Yu Sun Jian-Bo Xu Shu-Ling Chen Yu-Jie Yuan Hui Wu Jian-Jun Peng Chuang-Qi Chen Pi Guo Yuan-Tao Hao Yu-Long He Division of Gastrointestinal Surgery The First Affiliated Hospital Sun Yat-sen University Division of Gastroenterology The First Affiliated Hospital Sun Yat-sen University Department of Medical Statistics and Epidemiology School of Public Health Sun Yat-sen University

AIM: To assess the prognostic significance of immunological and nutritional-based indices, including the prognostic nutritional index(PNI), neutrophillymphocyte ratio(NLR), and platelet-lymphocyte ratio in gastric ***: We retrospectively reviewed 632 gastric cancer patients who underwent gastrectomy between1998 and 2008. Areas under the receiver operating characteristic curve were calculated to compare the predictive ability of the indices, together with estimating the sensitivity, specificity and agreement *** and multivariate analyses were performed to identify risk factors for overall survival(OS). Propensity score analysis was performed to adjust variables to control for selection ***: Each index could predict OS in gastric cancer patients in univariate analysis, but only PNI had independent prognostic significance in multivariate analysis before and after adjustment with propensity scoring(hazard ratio, 1.668; 95% confidence interval:1.368-2.035). In subgroup analysis, a low PNI predicted a significantly shorter OS in patients with stage Ⅱ-Ⅲ disease(P = 0.019, P < 0.001), T3-T4 tumors(P <0.001), or lymph node metastasis(P < 0.001). Canton score, a combination of PNI, NLR, and platelet, was a better indicator for OS than PNI, with the largest area under the curve for 12-, 36-, 60-mo OS and overall OS(P = 0.022, P = 0.030, P < 0.001, and P = 0.024,respectively). The maximum sensitivity, specificity, and agreement rate of Canton score for predicting prognosis were 84.6%, 34.9%, and 70.1%, ***: PNI is an independent prognostic factor for OS in gastric cancer. Canton score can be a novel preoperative prognostic index in gastric cancer.

关键词： Gastric cancer Prognostic nutritional index Canton score Prognosis neutrophil-lymphocyte ratio Platelet-lymphocyte ratio

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Folic Acid Supplementation Ameliorates Inflammation and Apoptosis in Ethanol-Induced Gastric Ulceration in Rats

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Journal of Biosciences and Medicines 2017年第12期5卷 101-117页

作者： K. O. Ajeigbe L. E. Jaja A. A. Onifade P. O. Obabueki W. M. Owonikoko School of Basic Medical Sciences Igbinedion University Okada Nigeria College of Medicine University of Ibadan Ibadan Nigeria

Although the gastroprotective potential of folic acid has been reported, little is known about the role of inflammation and apoptosis in the said activity. This study, therefore, assessed lipid peroxidation (LPO), neutrophil-lymphocyte ratio (NLR), C-reactive protein (CRP) as markers of inflammation and, p53 and BCl-2 as markers of apoptosis in ethanol-induced gastric ulcer pretreated with Folic acid (FA) for twenty-one (21) days. Adult male Wistar rats were arranged into experimental groups (n = 5) viz: 1) Control;2) Ulcer control;3) 2FA (2 mg/kg folic acid + Ulcer);4) 3FA (3 mg/kg folic acid + Ulcer);5) OMEP (20 mg/kg omeprazole + Ulcer);6) 2FA + OMEP + Ulcer;and 7) 3FA + OMEP + Ulcer. Ulcer score, LPO, NLR, serum CRP were all determined one hour post ulcer induction. Paraffin gastric sections were stained first with H & E, then immunostained for p53 and BCl-2. Ethanol caused gastric lesion with an index of 3.0 ± 0.2. Ulcer severity and LPO was significantly decreased in the 2FA, 3FA, OMEP, 2FA + OMEP and 3FA + OMEP groups. NLR reduced significantly in the 2FA, 3FA, OMEP and OMEP + 3FA group. Qualitatively, there was absence of C-reactive protein in the 2FA group while quantitatively, presence of CRP appeared sustained in the 3FA and OMEP treated groups. Unlike p53, the expression and labeling index of BCl-2 were significantly enhanced more in the FA and OMEP combination than OMEP alone. Folic acid ameliorates the development of gastric ulcer in rats via its anti-inflammatory and anti-apoptotic activities.

关键词： Folic Acid Lipid Peroxidation (LPO) neutrophil-lymphocyte Ratio (NLR)

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