检索结果-南通市图书馆

neurotrophic receptor tyrosine kinase family members in secretory and non-secretory breast carcinomas

World Journal of Clinical Oncology 2022年第2期13卷 135-146页

作者： Athina Stravodimou Ioannis A Voutsadakis Department of Medical Oncology CHUVLausanne 1011Switzerland Department of Medical Oncology Sault Area HospitalSault Ste Marie P6B0A8OntarioCanada

BACKGROUND Breast cancer is the most common female cancer and a major cause of morbidity and *** in breast cancer therapeutics has been attained with the introduction of targeted therapies for specific ***,other subsets lack targeted interventions and thus there is persisting need for identification and characterization of molecular targets in order to advance breast cancer *** To analyze the role of lesions in neurotrophic receptor tyrosine kinase(NTRK)genes in breast *** Analysis of publicly available genomic breast cancer datasets was performed for identification and characterization of cases with fusions and other molecular abnormalities involving NTRK1,NTRK2 and NTRK3 *** NTRK fusions are present in a small number of breast cancers at the extensive GENIE project data set which contains more than 10000 breast *** cases are not identified as secretory in the database,suggesting that the histologic characterization is not always *** the breast cancer The Cancer Genome Atlas(TCGA)cohort the more common molecular lesion in NTRK genes is amplification of NTRK1 observed in 7.9% of breast *** Neurotrophin receptors molecular lesions other than fusions are observed more often than ***,currently available NTRK inhibitors are effective mainly for fusion *** of NTRK1,being more frequent in breast cancers,could be a viable therapeutic target if inhibitors efficacious for them become available.

关键词： neurotrophic receptor tyrosine kinases Breast cancer Amplifications Fusions Tropomyosin related kinases

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：