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Emerging Applications of Optical Fiber‑Based Devices for Brain Research

Advanced Fiber Materials 2022年第1期4卷 24-42页

作者： Roya Nazempour Bozhen Zhang Zhongyin Ye Lan Yin Xianli Lv Xing Sheng Department of Electronic Engineering Center for Flexible Electronics TechnologyIDG/McGovern Institute for Brain ResearchBeijing National Research Centre for Information Science and TechnologyTsinghua UniversityBeijing 100084China School of Materials Science and Engineering The Key Laboratory of Advanced MaterialsState Key Laboratory of New Ceramics and Fine ProcessingCenter for Flexible Electronics TechnologyTsinghua UniversityMinistry of EducationBeijing 10084China Neurosurgery Department School of Clinical MedicineBeijing Tsinghua Changgung HospitalTsinghua UniversityBeijing 102218China

Research in neuroscience and neuroengineering has attracted tremendous interest in the past ***,the complexity of the brain tissue,in terms of its structural,chemical,mechanical,and optical properties,makes the interrogation of biophysical and biochemical signals within the brain of living animals extremely *** a viable and versatile tool for brain studies,optical fber based technologies have provided exceptional opportunities to unravel the mysteries of the brain and open the door for clinical applications in the treatment,diagnosis,and prevention of neurological ***,optical fbers with diameters from 10 to 1000μm are capable of guiding and delivering light to deep levels of the living ***,small dimensions of such devices along with their fexibility and light weight paved the way for understanding the complex behaviours of living and freely moving *** article provides a review of the emerging applications of optical fbers in neuroscience,specifcally in the mammalian *** utilities,including optogenetics,fuorescence sensing,drug administration and phototherapy,are *** also discuss other biological applications of such implantable fbers,which may provide insights into the future study of *** is envisioned that these and other optical fber based techniques ofer a powerful platform for multi-functional neural activity sensing and modulation.

关键词： Optical fbers neuroscience Optogenetics Biosensing

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All-fiber-transmission photometry for simultaneous optogenetic stimulation and multi-color neuronal activity recording

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Opto-Electronic Advances 2022年第12期5卷 20-34,F0004页

作者： Zhongyang Qi Qingchun Guo Shu Wang Mingyue Jia Xinwei Gao Minmin Luo Ling Fu Britton Chance Center for Biomedical Photonics Wuhan National Laboratory for OptoelectronicsHuazhong University of Science and TechnologyWuhan 430074China MoE Key Laboratory for Biomedical Photonics School of Engineering SciencesHuazhong University of Science and TechnologyWuhan 430074China National Institute of Biological Sciences Beijing 102206China Beijing Advanced Innovation Center for Big Data-Based Precision Medicine Beijing 100191China School of Biomedical Engineering Capital Medical UniversityBeijing 100069China Chinese Institute for Brain Research Beijing 102206China School of Life Sciences Tsinghua UniversityBeijing 100084China

Manipulating and real-time monitoring of neuronal activities with cell-type specificity and precise spatiotemporal resolution during animal behavior are fundamental technologies for exploring the functional connectivity, information transmission, and physiological functions of neural circuits in vivo. However, current techniques for optogenetic stimulation and neuronal activity recording mostly operate independently. Here, we report an all-fiber-transmission photometry system for simultaneous optogenetic manipulation and multi-color recording of neuronal activities and the neurotransmitter release in a freely moving animal. We have designed and manufactured a wavelength-independent multi-branch fiber bundle to enable simultaneous optogenetic manipulation and multi-color recording at different wavelengths. Further, we combine a laser of narrow linewidth with the lock-in amplification method to suppress the optogenetic stimulation-induced artifacts and channel crosstalk. We show that the collection efficiency of our system outperforms a traditional epi-fluorescence system. Further, we demonstrate successful recording of dynamic dopamine(DA) responses to unexpected rewards in the nucleus accumbens(NAc) in a freely moving mouse. We also show simultaneous dual-color recording of neuronal Ca2+ signals and DA dynamics in the NAc upon delivering an unexpected reward and the simultaneous optogenetic activating at dopaminergic terminals in the same location. Thus, our multi-function fiber photometry system provides a compatible, efficient, and flexible solution for neuroscientists to study neural circuits and neurological diseases.

关键词： fiber photometry all-fiber-transmission multi-color optogenetic neuroscience

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城市环境对女性情绪健康影响及规划提升研究--基于神经科学实验的广州实证

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China City Planning Review 2023年第1期32卷 17-27页

作者：仲绍明袁媛王琳婷 School of Geography and Planning Sun Yat-Sen UniversityGuangzhouChina

The quality of urban environment has a profound impact on the health of women–one of the core subjects of urban *** on neuroscientific methods,such as the Functional Near-Infrared Spectroscopy(fNIRS)and the E4 wristband and taking a road section in Guangzhou as an example,this paper explores the impact of urban environment on women’s emotional health from both objective physiological indicators and subjective psychological *** study finds that both environment type and travel sequence have a different impact on women’s *** level of spatial openness,the sudden change of environment type,and the mixed traffic flow are the main factors contributing to fluctuations in female participants’emotional *** with the neuroscience experiment results and an in-depth interview,it proposes women-friendly planning and design strategies,such as improving vision permeability and creating reasonable transitional space,in order to provide a reference for the construction of healthy cities focusing on key populations.

关键词： women’s health urban environment healthy cities neuroscience

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The Cell Cycle in the Central Nervous System 1

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丛书名： Contemporary neuroscience

2006年

作者： Damir Janigro

来源：畅想之星图书光盘版（南... 评论

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Equilibrium as the common ground:Introducing embodied perception into structural design with graphic statics

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Frontiers of Architectural Research 2022年第3期11卷 574-589页

作者： Shuaizhong Wang Toni Kotnik Joseph Schwartz Ting Cao Department of Architecture ETH ZurichZurich8093Switzerland Department of Architecture Aalto UniversityEspoo02150Finland Department of Architecture Harbin Institute of Technology(Shenzhen)Shenzhen518055China

The analogy between the human body and architectural structures dates all the way back to ancient times and has significantly shaped the design of buildings and *** article examines the body’s historical influence on how structures are perceived and designed,demonstrating how the body shapes the"technical truth"dimension of structural design while oblivious to the importance of an"artistic truth"or perceptual *** article aims to connect recent neuroscience findings and their implications for structural design through graphic statics and its design ***,this article proposes an equilibrium-based structural design approach for designing embodied structures based on graphic statics.

关键词： Structural design Body Equilibrium Perception Graphic statics neuroscience

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Advances in nanomaterials for brain microscopy

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Nano Research 2018年第10期11卷 5144-5172页

作者： Jackson T. Del Bonis-O'Donnell Linda Chio Gabriel F. Dorlhiac lan R. McFarlane Markita P. Landry Department of Chemical and Biomolecular Engineering University of California Berkeley CA 94720 USA Biophysics Graduate Group University of California Berkeley CA 94720 USA Innovative Genomics Institute (IGI) Berkeley CA 94720 USA California Institute for Quantitative Biosciences QB3 University of California Berkeley CA 94720 USA Chan-Zuckerberg Biohub San Francisco CA 94158 USA

Microscopic imaging of the brain continues to reveal details of its structure, connectivity, and function. To further improve our understanding of the emergent properties and functions of neural circuits, we need to directly visualize the relationship between brain structure, neuron activity, and neurochemistry. Advances in the chemical and optical properties of nanomaterials, and developments in deep-tissue microscopy, may help to overcome the current challenges of in-vivo brain imaging, particularly when imaging the brain through optically-dense brain tissue, skull, and scalp. Developments in nanomaterials may enable the implementation of tunable chemical functionality for neurochemical targeting and sensing, and fluorescence stability for long-term imaging. In this review, we summarize the current methods used for brain microscopy and describe the diverse classes of nanomaterials recently offered as contrast agents and functional probes for microscopic optical imaging of the brain.

关键词： nanomaterials neuroscience imaging microscopy

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Microglia as hackers of the matrix:sculpting synapses and the extracellular space

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Cellular & Molecular Immunology 2021年第11期18卷 2472-2488页

作者： Joshua D.Crapser Miguel A.Arreola Kate I.Tsourmas Kim N.Green Department of Neurobiology and Behavior University of CaliforniaIrvineCAUSA

Microglia shape the synaptic environment in health and disease,but synapses do not exist in a ***,pre-and postsynaptic terminals are surrounded by extracellular matrix(ECM),which together with glia comprise the four elements of the contemporary tetrapartite synapse *** research in this area is still just beginning,accumulating evidence points toward a novel role for microglia in regulating the ECM during normal brain homeostasis,and such processes may,in turn,become dysfunctional in *** it relates to synapses,microglia are reported to modify the perisynaptic matrix,which is the diffuse matrix that surrounds dendritic and axonal terminals,as well as perineuronal nets(PNNs),specialized reticular formations of compact ECM that enwrap neuronal subsets and stabilize proximal *** interconnected relationship between synapses and the ECM in which they are embedded suggests that alterations in one structure necessarily affect the dynamics of the other,and microglia may need to sculpt the matrix to modify the synapses ***,we provide an overview of the microglial regulation of synapses,perisynaptic matrix,and PNNs,propose candidate mechanisms by which these structures may be modified,and present the implications of such modifications in normal brain homeostasis and in disease.

关键词： neuroscience Perineuronal nets Microglia Extracellular matrix Neuroinflammation

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Rat Cerebrospinal Fluid Treatment Method through Cisterna Cerebellomedullaris Injection

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neuroscience Bulletin 2018年第5期34卷 827-832页

作者： Thaina Garbino dos Santos Mery Stefani Leivas Pereira Diogo Losch Oliveira Laboratory of Cellular Neurochemistry Departamento de Bioquimica Instituto de Ciencias Basicas da Saude Universidade Federal do Rio Grande do Sul Porto Alegre RS 90035-003 Brazil

Drugs that lack the ability to cross the blood- brain barrier （BBB） need to be placed directly into the central nervous system. Our laboratory studies the involve- ment of the glutamatergic system in the aggressiveness of glioma, and some ligands of glutamate receptors cannot permeate the BBB. Here, glioma-implanted rats were treated by a technique that delivers ligands directly into the cerebrospinal fluid by puncture into the cisterna cerebel- lomedullaris. Rats were anesthetized and fixed in a rodent stereotactic device. The head was gently tilted downwards at an angle that allowed exposure of the cisterna. Injection into the cisterna was done freehand using a gingival needle coupled to a microsyringe. The efficiency of intracisternal injection was demonstrated using a methylene blue solu- tion. This type of injection is adaptable for any rodent model using small volumes of a variety of other drugs, and is an interesting method for neuroscience studies.

关键词： Neurobiology neuroscience Drug administration Intracisternal injection Cisterna magna Cerebrospinal fluid treatment Central nervous system Surgical technique Rodent

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Deciphering Brain Complexity Using Single-cell Sequencing

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Genomics, Proteomics & Bioinformatics 2019年第4期17卷 344-366页

作者： Quanhua Mu Yiyun Chen Jiguang Wang Department of Chemical and Biological Engineering Division of Life Science Center for Systems Biology and Human Health and State Key Laboratory of Molecular Neuroscience The Hong Kong University of Science and Technology

The human brain contains billions of highly differentiated and interconnected cells that form intricate neural networks and collectively control the physical activities and high-level cognitive functions,such as memory,decision-making,and social *** data is required to decipher the complexity of cell types,as well as connectivity and functions of the *** newly developed single-cell sequencing technology,which provides a comprehensive landscape of brain cell type diversity by profiling the transcriptome,genome,and/or epigenome of individual cells,has contributed substantially to revealing the complexity and dynamics of the brain and providing new insights into brain development and brain-related *** this review,we first introduce the progresses in both experimental and computational methods of single-cell sequencing *** of single-cell sequencing-based technologies in brain research,including cell type classification,brain development,and brain disease mechanisms,are then elucidated by representative ***,we provided our perspectives into the challenges and future developments in the field of single-cell *** summary,this mini review aims to provide an overview of how big data generated from single-cell sequencing have empowered the advancements in neuroscience and shed light on the complex problems in understanding brain functions and diseases.

关键词： neuroscience Single-cell RNA-seq Cell type Brain development Brain diseases

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Cross inhibition improves activity selection when switching incurs time costs

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Current Zoology 2015年第2期61卷 242-250页

作者： James A. R. MARSHALL Angelique FAVR EAU-PEIGN Lutz FROMHAGE John M. MCNAMARA Liarme F. S. MEAH Alasdair I. HOUSTON Department of Computer Science and University of Sheffield Sheffield S 1 4DP UK INRA UMR791 Modelisation Systemique Appliquee aux Ruminants F-75005 Paris France Department of Biological and Environmental Science P.O. Box 35 FI-40014 University of Jyvaskyla Finland School of Mathematics University of Bristol University Walk Bristol BS8 1TW UK School of Biological Sciences University of Bristol Bristol Life Sciences Building 24 Tyndall Avenue Bristol BS8 1TQ UK AgroParisTech UMR Modelisation Systemique Appliquee anx Ruminants F-75005 Paris France

We consider a behavioural model of an animal choosing between two activities, based on positive feedback, and exa- mine the effect of introducing cross inhibition between the motivations for the two activities. While cross-inhibition has pre- viously been included in models of decision making, the question of what benefit it may provide to an animal＇s activity selection behaviour has not previously been studied. In neuroscience and in collective behaviour cross-inhibition, and other equivalent means of coupling evidence-accumulating pathways, have been shown to approximate statistically-optimal decision-making and to adaptively break deadlock, thereby improving decision performance. Switching between activities is an ongoing decision process yet here we also find that cross-inhibition robustly improves its efficiency, by reducing the frequency of costly switches between behaviours .

关键词： Crossinhibition Geometric framework Foraging Activity selection neuroscience Behaviour

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