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Mesenchymal stromal cell biotherapy for Parkinson’s disease premotor symptoms

Chinese Neurosurgical Journal 2023年第4期9卷 300-314页

作者： Jinmei Sun Wei Zhang Zheng Zachory Wei Xiaopeng Song Liu Jian Feng Jiang Shuanglin Wang Haibo Li Yongbo Zhang Houzhen Tuo The CtrLyin Group Clinical Diagnosis and Treatment Center for Parkinson’s Disease Beijing Friendship HospitalBeijingChina Laboratories of Biological Therapeutic Medical Technology Department of NeurologyBeijing Friendship Hospital Center for Neurological DisordersCapital Medical UniversityBeijingChina National Clinical Research Center for Digestive Diseases Beijing Friendship HospitalNeuroscience InstituteBeijingChina Department of Anesthesiology Emory University School of MedicineAtlantaGAUSA Beijing Tropical Medicine Research Institute BeijingChina McLean Imaging Center McLean HospitalHarvard Medical SchoolBelmontMAUSA Neuroscience Research Institute Peking UniversityBeijingChina Casstar Zhongguancun No.1 Global Key&Core Technology(AI)Innovation CenterBeijingChina Department of Critical Care Medicine Airport Hospital of Tianjin Medical University General HospitalTianjinChina Department of Cardiovascular Thoracic Surgery Tianjin Medical University General HospitalTianjinChina Department of Biochemistry and Cell Biology Geisel School of MedicineDartmouth CollegeHanoverNHUSA 不详

Parkinson’s disease(PD)is a neurodegenerative disorder with motor deficits due to nigrostriatal dopamine depletion and with the non-motor/premotor symptoms(NMS)such as anxiety,cognitive dysfunction,depression,hyposmia,and sleep *** is presented in at least one-fifth of the patients with *** the histological information being investigated,stem cells are shown to provide neurotrophic supports and cellular replacement in the damaging brain areas under PD *** change of progressive PD includes degeneration and loss of dopaminergic neurons in the substantia nigra of the *** current stem cell beneficial effect addresses dopamine boost for the striatal neurons and gliovascular mechanisms as competing for validated PD drug *** addition,there are clinical interventions for improving the patient’s NMS and targeting their autonomic dysfunction,dementia,mood disorders,or sleep *** our and many others’research using brain injury models,multipotent mesenchymal stromal cells demonstrate an additional and unique ability to alleviate depressive-like behaviors,independent of an accelerated motor *** delivery of the stem cells is discussed for it is extensively tested in rodent animal models of neurological and psychiatric *** this review,we attempt to discuss the repairing potentials of transplanted cells into parkinsonism pathological regions of motor deficits and focus on preventive and treatment *** new approaches in the PD biological therapy,it is believed that it can as well benefit patients against PD-NMS.

关键词： Cell therapy Cognitive impairment Depression neuronal survival and differentiation Parkinson's disease

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