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A review of cell-type specific circuit mechanisms underlying epilepsy

Acta Epileptologica 2024年第2期7卷 75-86页

作者： Peilin Zhao Xiaomi Ding Lini Li Guohui Jiang Institute of Neurological Diseases Affiliated Hospital of Clinical School of MedicineNorth Sichuan Medical CollegeNanchongSichuan 637000China Nanomedicine Innovation Research and Development Transformation Institute Affiliated Hospital of Clinical School of MedicineNorth Sichuan Medical CollegeNanchongSichuan 637000China Department of Neurology Affiliated Hospital of Clinical School of MedicineNorth Sichuan Medical CollegeNanchongSichuan 637000China

Epilepsy is a prevalent neurological disorder,yet its underlying mechanisms remain incompletely ***-mulated studies have indicated that epilepsy is characterized by abnormal neural *** the circuit mechanisms is crucial for comprehending the pathogenesis of *** advances in tracing and modulating tools for neural circuits,some epileptic circuits have been *** comprehensive review focuses on the cir-cuit mechanisms underlying epilepsy in various neuronal subtypes,elucidating their distinct *** seizures are primarily characterized by the hyperactivity of glutamatergic neurons and inhibition of GABAergic ***-ever,specific activated GABAergic neurons and suppressed glutamatergic neurons exacerbate epilepsy through pref-erentially regulating the activity of GABAergic neurons within epileptic *** subtypes of GABAergic neurons contribute differently to epileptic activities,potentially due to their diverse connection ***,identical GABAergic neurons may assume distinct roles in different stages of *** GABAergic neurons and glutamatergic neurons with long-range projecting fibers innervate multiple nuclei;nevertheless,not all of these circuits contribute to epileptic *** circuits originating from the same nuclei may display diverse con-tributions to epileptic activities,and certain glutamatergic circuits from the same nuclei may even exert opposing effects on *** neurons,including cholinergic,serotonergic,dopaminergic,and noradrenergic neurons,are also implicated in epilepsy,although the underlying circuit mechanisms remain poorly *** studies suggest that epileptic nuclei establish intricate connections through cell-type-specific circuits and play pivotal roles in ***,there are still limitations in knowledge and methods,and further understanding of epileptic circuits is crucial,particularly in the context of

关键词： Epilepsy Circuit mechanisms Cell-type specific neuromodulatory

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Scientific progress regarding neural regeneration in the Web of Science A 10-year bibliometric analysis

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Neural Regeneration Research 2013年第36期8卷 3449-3454页

作者： Yuntao Pan Yuhua Zhang Xiaopei Gao Jia Jia Jiping Gao Zheng Ma Institute of Scientific and Technical Information of China (ISTIC)

BACKGROUND： Neural regeneration following nerve injury is an emerging field that attracts ex- tending interests all over the world. OBJECTIVE： To use bibliometric indexes to track studies focusing on neural regeneration, and to investigate the relationships among geographic origin, countries and institutes, keywords in the published articles, and especially focus on the region distribution, institution distribution, as well as collaborations in Chinese papers indexed in the Web of Science. METHODS： A list of neural regeneration studies was generated by searching the database of the Web of Science-Expanded using the term ＂Neural Regenera＊＂. Inclusive criteria：（1） articles in the field of neural regeneration; （2） fundamental research on animals, clinical trials and case reports; （3） article types： article, review, proceedings paper, note, letter, editorial material, discussion, book chapter; （4） year of publication： 2003-2012; and （5） citation database： Science Citation Index-Expanded. Exclusive criteria：（1） articles requiring manual searching or with access only by telephone; （2） unpublished articles; and （3） corrections. RESULTS： A total of 4 893 papers were retrieved from the Web of Science published between 2003 and 2012. The papers covered 65 countries or regions, of which the United States ranked first with 1 691 papers. The most relevant papers were in the neurosciences and cell biology, and the key- word ＂stem cell＂ was the most frequent. In recent years, China showed a great increase in the number of papers. Over the entire 10 years, there were 922 Chinese papers, with Jilin University ranking first with 58 articles. Chinese papers were published in connection with many countries, in- cluding the United States, Japan, and the United Kingdom. Among the connections, the papers published by the Chinese and the American are 107, with the highest rate. With regard to funding, 689 articles were funded from various projects, occupying 74.72% of the total amount. I

关键词： neural regeneration bibliometrics neurogenesis neuroplasticity neuroprotective neuromodulatory neurorestoration stem cells neurodegenerative disease grants-supported paper neuroregeneration

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Oscillating Mechanical Stimulation of the Craniocervical Region as Physical Therapy for Chronic Migraine: A Pilot Trial

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International Journal of Clinical Medicine 2019年第3期10卷 150-160页

作者： Makoto Shiraishi Munefumi Hotta Tomohiro Suzuki Noboru Imai Division of Neurology Department of Internal Medicine St Marianna University School of Medicine Kawasaki Japan Hotta Clinic Shizuoka Japan Suzuki Osteopathic Clinic Shizuoka Japan Department of Neurology Japanese Red Cross Shizuoka Hospital Shizuoka Japan

Objective: We conducted a prospective trial of oscillating mechanical stimulation (OS) of the craniocervical region as treatment for drug-refractory chronic migraine (CM). Methods: Ten patients (8 women, 2 men;mean age 47.0 ±15.1 years) were enrolled. The treatment was administered over an 8-week period to 13, 4, and 9 sites on the face and head, neck, and upper back, respectively, at 5- to 15-pound intensity. The primary outcome measure was the number of days patients suffered a migraine (hereafter “number of migraine days”), and the secondary outcome measures were the six-item Headache Impact Test (HIT-6) and Visual Analog Scale (VAS) scores for migraine pain intensity and the nine-item Patient Health Questionnaire (PHQ-9) and the seven-item Generalized Anxiety Disorder (GAD-7) scale scores. Results: Nine patients completed treatment. The number of migraine days remained unchanged, from a mean 21.7 ±11.6 days/month before treatment to 19.3 ±7.3 days/month upon completion of treatment. However, the HIT-6 scores improved from 67.0 ±8.2 to 61.4 ±7.1 (p = 0.007) after 3 weeks, 61.1 ±11.5 (p = 0.01) after 6 weeks, and 59.9 ±11.6 (p = 0.035) upon completion of treatment. Similarly, the VAS scores improved significantly from 7.3 ±1.7 to 5.7 ±3.1 (p = 0.018) at 6 weeks and 4.8 ±2.8 (p = 0.011) upon completion of treatment. The GAD-7, PHQ-9, and allodynia scale scores remained unchanged. Conclusion: Our data suggest that OS is well tolerated and may become a feasible form of treatment for drug-resistant CM.

关键词： Chronic Migraine Oscillating Mechanical Stimulation Drug Resistance Nondrug Treatment neuromodulatory Effect

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