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传承与发展，创湖南省生理科学事业的新高——湖南省生理科学会2011年度学术年会

作者： TANG Xiao-qing1, 2, ZHOU Cheng-fang1, 2(1. Institute of Cognition and Nervous system diseases, Medical College, University of south China, Hengyang, 421001, Hunan, P.R. China 2. Department of Physiology, Medical College, University of South China, Hengyang, 421001, Hunan, P.R. China)

Objective This review discusses the current status and progress in studies on the roles of hydrogen sulfide (H2S) in regulation of neurotoxicity, neuroprotection, and neuromodulator, as well as its therapeutic potenti... 详细信息

关键词： Hydrogen sulfide neuromodulator Neuroprotectant

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Molecular characterization of a proline transporter from Chilo suppressalis

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Insect Science 2011年第5期18卷 495-502页

作者： Jia Huang Shun-Fan Wu Gong-Yin Ye State Key Laboratory of Rice Biology Ministry of Agriculture Key Laboratory of Molecular Biology of Crop Pathogens and Insects Instituteof Insect Sciences Zhejiang University Hangzhou China

Proline plays an important role in regulating synaptic neurotransmission in both mammalian and insect nervous systems. The full-length complementary DNA sequences encoding the proline transporter gene （CsProT） and its alternative spliced transcript （CsProT-ST） were cloned from the striped stem borer （SSB）, Chilo suppressalis, one of the most important rice pests in Asia. The comparison of amino acid sequences showed that CsProT is highly similar to the proline transporter isolated from Manduca sexta （MasProT）. The developmental changes of the relative messenger RNA expression levels of CsProT and CsProT-ST genes were examined in SSB. The expression level of CsProT-ST is much higher than that of CsProT in all developmental periods, suggesting that the Y-end spliced variant is the major transcript instead of CsProT. The highest ex- pression level of both genes in the pupal stage means that proline may be involved in some unclear functions in the metamorphosis from pupa to adulthood.

关键词： Chilo suppressalis mRNA expression neuromodulator proline transporter

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A proctolin-like peptide is regulated after baculovirus infection and mediates in caterpillar locomotion and digestion

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Insect Science 2022年第1期29卷 230-244页

作者： Angel Llopis-Giménez Stefano Parenti Yue Han Vera I.D.Ros Salvador Herrero Department of Genetics and Institut Universitari en Biotecnologia i Biomedicina(BIOTECMED) Universitat de ValenciaValenciaSpain Laboratory of Virology Wageningen University and ResearchWageningenthe Netherlands Current address.Department of Pathology University of CambridgeCambridgeUK

Baculoviruses constitute a large group of invertebrate DNA viruses, predominantly infecting larvae of the insect order Lepidoptera. During a baculovirus infection, the virus spreads throughout the insect body producing a systemic infection in multiple larval tissues, included the central nervous system (CNS). As a main component of the CNS, neuropeptides are small protein-like molecules functioning as neurohormones, neurotransmitters, or neuromodulators. These peptides are involved in regulating animal physiology and behavior and could be altered after baculovirus infection. In this study, we have investigated the effect of Spodoptera exigua multiple nucleopolyhedrovirus (SeMNPV) infection on expression of Spodoptera exigua neuropeptides and neuropeptide-like genes. Expression of the gene encoding a polypeptide that resembles the well-known insect neuropeptide proctolin and named as proctolin-like peptide (PLP), was downregulated in the larval brain following infection and was chosen for further analysis. A recombinant Autographa californica multiple nucleopolyhedrovirus (AcMNPV) overexpressing the C-terminal part of the PLP was generated and used in bioassays using S. exigua larvae to study its influence on the viral infection and insect behavior. AcMNPV-PLP-infected larvae showed less locomotion activity and a reduction in growth compared to larvae infected with wild type AcMNPV or mock-infected larvae. These results are indicative of this new peptide as a neuromodulator that regulates visceral and skeletal muscle contractions and offers a novel effector involved in the behavioral changes during baculovirus infection.

关键词： beet armyworm behavior neuromodulator neuropeptide physiology SeM-NPV

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Median arcuate ligamentum syndrome:Four case reports

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World Journal of Clinical Cases 2022年第6期10卷 1991-1997页

作者： Ji Eun Kim Poong Lyul Rhee Division of Gastroenterology Samsung Medical CenterSeoul 06351South Korea

BACKGROUND Median arcuate ligamentum syndrome(MALS)is a disease entity with unclear *** it is not considered in advance,the clinical diagnosis of the disease is very difficult because patients complain of digestive discomfort including ***,this characteristic is not specific to *** have been no studies to assist in making a quick *** aim of this case series was to recognize that MALS must be considered as a differential factor in the cause of abdominal *** SUMMARY We described cases in which four patients complained of abdominal pain over a long period but in whom a diagnosis of MALS could not be *** the gastroenterologist does not take into account abdominal pain in advance,the patient is considered an asymptomatic gallstone patient and has their gallbladder removed despite imaging *** patient may also be considered a psychiatric patient and may be administered psychiatric drugs over a long *** all four cases in this report,the patients experienced abdominal *** three cases,the diagnosis was possible by the clinician’s judgment considering both clinical symptoms and imaging techniques shortly after the onset of ***,in one case that lasted over 20 years,a clear diagnosis was not *** after complaining of colicky pain and performing a cholecystectomy,the diagnosis was made only after the symptoms *** all four cases,the symptoms were relieved by *** MALS is a rare disease and it is easy to miss because it is not malignant,but patients can suffer from pain over a long *** the accurate diagnosis of a patient complaining of abdominal pain,the diagnosis must be *** addition,as there are asymptomatic patients,patients who need treatment should be carefully selected,and improvement with medical treatment can be ***-scale studies are also needed.

关键词： Median arcuate ligamentum syndrome Abdominal pain Missed diagnosis neuromodulator Celiac artery compression Case report

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Hydrogen sulfide and nervous system regulation

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Chinese Medical Journal 2011年第21期124卷 3576-3582页

作者： ZHOU Cheng-fang TANG Xiao-qing Department of Physiology Institute of Cognition and Nervous Systems Disease Medical College University of South China Hengyang Hunan 421001 China

Objective This review discusses the current status and progress in studies on the roles of hydrogen sulfide （H2S） in regulation of neurotoxicity, neuroprotection, and neuromodulator, as well as its therapeutic potential for neurodegenerative disorders. Data sources The data used in this review were mainly from Medline and PubMed published in English from 2001 to August 2011. The search terms were ＂hydrogen sulfide＂, ＂neuron＂, and ＂neurodegenerative disorders＂. Study selection Articles regarding the regulation of neuronal function, the protection against neuronal damage and neurological diseases, and their possible cellular and molecular mechanisms associated with H2S were selected. Results The inhibited generation of endogenous H2S is implicated in 1-methy-4-phenylpyridinium ion, 6-OHDA, and homocysteine-triggered neurotoxicity. H2S elicits neuroprotection in Alzheimer＇s disease and Parkinson＇s disease models as well as protecting neurons against oxidative stress, ischemia, and hypoxia-induced neuronal death. H2S offers anti-oxidant, anti-inflammatory and anti-apoptotic effects, as well as activates ATP-sensitive potassium channels and cystic fibrosis transmembrane conductance regulator CI channels. H2S regulates the long-term potentiation （LTP） and GABAB receptors in the hippocampus, as well as intracellular calcium and pH homeostasis in neurons and gila cells. Conclusions These articles suggest that endogenous H2S may regulate the toxicity of neurotoxin. H2S not only acts as a neuroprotectant but also serves as a novel neuromodulator.

关键词： hydrogen sulfide neuromodulator neuroprotectant

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