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Point application with Angong Niuhuang sticker protects hippocampal and cortical neurons in rats with cerebral ischemia

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Neural Regeneration Research 2015年第2期10卷 286-291页

作者： Dong-shu Zhang Yuan-liang Liu Dao-qi Zhu Xiao-jing Huang Chao-hua Luo College of Traditional Chinese Medicine Southern Medical University

Angong Niuhuang pill, a Chinese materia medica preparation, can improve neurological func-tions after acute ischemic stroke. Because of its inconvenient application and toxic components （Cinnabaris andRealgar）, we used transdermal enhancers to deliverAngong Niuhuang pill by modern technology, which expanded the safe dose range and clinical indications. In this study, Angong Niuhuang stickers administered at different point application doses （1.35, 2.7, and 5.4 g/kg） were administered to theDazhui （DU14）, Qihai（RN6） andMingmen （DU4） of rats with chronic cerebral ischemia, for 4 weeks. The Morris water maze was used to determine the learning and memory ability of rats. Hematoxylin-eosin staining and Nissl staining were used to observe neuronal damage of the cortex and hippocampal CA1 region in rats with chronic cerebral ischemia. The middle- and high-dose point application ofAngong Niuhuangstickers attenuated neuronal damage in the cortex and hippocampal CA1 region, and improved the memory of rats with chronic cerebral ischemia with an efifcacy similar to interventions by electroacupuncture at Dazhui （DU14）,Qihai （RN6） andMingmen （DU4）. Our experimental ifndings indicate that point application withAngong Niuhuang stickers can improve cognitive function after chronic cerebral ischemia in rats and is neuroprotective with an equivalent efifcacy to acupuncture.

关键词： nerve regeneration cerebral ischemia point application Angong Niuhuang sticker brain injury neurological functions acupuncture traditional Chinese medicine NSFC grants neural regeneration

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Glutamate-releasing BEST1 channel is a new target for neuroprotection against ischemic stroke with wide time window

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Acta Pharmaceutica Sinica B 2023年第7期13卷 3008-3026页

作者： Shuai Xiong Hui Xiao Meng Sun Yunjie Liu Ling Gao Ke Xu Haiying Liang Nan Jiang Yuhui Lin Lei Chang Haiyin Wu Dongya Zhu Chunxia Luo Department of Pharmacology School of PharmacyNanjing Medical UniversityNanjing 211166China Department of Medicinal Chemistry School of PharmacyNanjing Medical UniversityNanjing 211166China Collaborative Innovation Center for Cardiovascular Disease Translational Medicine Nanjing Medical UniversityNanjing 211166China

Many efforts have been made to understand excitotoxicity and develop neuroprotectants for the therapy of ischemic *** narrow treatment time window is still to be *** that the ischemic core expanded over days,treatment with an extended time window is ***1(BEST1)belongs to a bestrophin family of calcium-activated chloride *** revealed an increase in neuronal BEST1 expression and function within the peri-infarct from 8 to 48 h after ischemic stroke in *** the protein expression or inhibiting the channel function of BEST1 by genetic manipulation displayed neuroprotective effects and improved motor functional *** electrophysiological recordings,we demonstrated that extrasynaptic glutamate release through BEST1 channel resulted in delayed ***,we confirmed the therapeutic efficacy of pharmacological inhibition of BEST1 during 6—72 h post-ischemia in *** delayed treatment prevented the expansion of infarct volume and the exacerbation of neurological *** study identifies the glutamatereleasing BEST1 channel as a potential therapeutic target against ischemic stroke with a wide time window.

关键词： BEST1 Ischemic stroke Glutamate release Delayed excitotoxicity Infarct expansion neurological functions Calcium-activated chloride channels

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Metabolic syndromeaugments the risk of early neurological deterioration in acute ischemic stroke patients independent of inflammatory mediators:a hospital-based prospective study

Metabolic syndromeaugments the risk of early neurological de...

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第二届国际抑郁共病暨第十二届中国中西医结合基础理论学术研讨会

作者： Lei Sheng Department of Neurology Second Affiliated Hospital of Nanjing University of Chinese Medicine

Background and Aims:Metabolic syndrome(MetS) has been associated with occurrence and prognosis of ischemic *** study aimed to evaluate whether an association exists between MetS and early neurological deterioration(END) following acute ischemic stroke and the possible role inflammatory biomarkers *** and Results:We conducted a prospective cohort investigation involved 208 stroke patients within 48 hours from symptom *** was determined by the modified National Cholesterol Education Program/Adult Treatment Panel Ⅲ *** was defined as an increase of ≥ 1 point in motor power or ≥ 2 points in the total National Institute of Health Stroke Scale(NIHSS) score within 7 *** logistic regression analysis showed that patients with MetS had a 125%increased risk of END(OR 2.25;95%CI 1.71-4.86,P = 0.005).After adjustment for fibrinogen and high-sensitivity C-reactive protein,MetS remained significantly correlatedto END(OR 2.20;95%CI 1.10-4.04,P = 0.026) with a 77%elevated risk per additional MetS trait(OR 1.77;95%CI 1.23-2.58,P = 0.002).Conclusions:This study demonstrated that MetS may be a potential predictor for END after ischemic stroke,which was independent of raised inflammatory mediators.

关键词： Ischemic stroke Metabolicsyndrome neurological functions Inflammatory mediators

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