检索结果-南通市图书馆

Acupuncture for cervical dystonia associated with anxiety and depression: A case report

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2024年第1期12卷 204-209页

作者： Ya-Ting Zhang Jin-Jing Zhang Bi-Xiang Zha Yin-Qiu Fan Yuan-Bo Xu Jun Yang Qing-Ping Zhang The First School of Clinical Medicine Anhui University of Chinese MedicineHefei 230031Anhui ProvinceChina Acupuncture and Rehabilitation Department First Affiliated Hospital of Anhui University of Chinese MedicineHefei 230031Anhui ProvinceChina College of Acupuncture and Tuina Anhui University of Chinese MedicineHefei 230031Anhui ProvinceChina

BACKGROUND Cervical dystonia(CD)is a type of muscle tone disorder that usually occurs in the neck muscles.Due to the intermittent or continuous involuntary contraction of the neck muscles,the head and neck are twisted and skewed and some postural abnormalities occur.Long-term abnormal posture or pain can cause negative emotions in patients,which can affect their quality of life.CASE SUMMARY This case report included a 37-year-old woman who was diagnosed with CD associated with anxiety and depression;the accompanying symptoms were head and neck tilt of approximately 90°to the right and mental abnormality.After two courses of acupuncture treatment,the patient’s head and neck can be maintained in a normal position,and the negative emotions can be relieved.CONCLUSION This case indicates that acupuncture can effectively improve CD and the emotional state and quality of life of patients,making it an effective alternative treatment for the condition.

关键词： Cervical dystonia Anxiety and depression neurological disease Acupuncture Case report

Advances and Applications of Brain Organoids

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neuroscience Bulletin 2023年第11期39卷 1703-1716页

作者： Yang Li Peng‑Ming Zeng Jian Wu Zhen‑Ge Luo School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China

Understanding the fundamental processes of human brain development and diseases is of great importance for our health.However,existing research models such as non-human primate and mouse models remain limited due to their developmental discrepancies compared with humans.Over the past years,an emerging model,the“brain organoid”integrated from human pluripotent stem cells,has been developed to mimic developmental processes of the human brain and disease-associated phenotypes to some extent,making it possible to better understand the complex structures and functions of the human brain.In this review,we summarize recent advances in brain organoid technologies and their applications in brain development and diseases,including neurodevelopmental,neurodegenerative,psychiatric diseases,and brain tumors.Finally,we also discuss current limitations and the potential of brain organoids.

关键词： Human pluripotent stem cell Brain organoid Brain development neurological disease

Clinical application prospects and transformation value of dental follicle stem cells in oral and neurological diseases

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Stem Cells 2023年第4期15卷 136-149页

作者： Chao Yang Xin-Ya Du Wen Luo Research and Development Department Shenzhen Uni-medica Technology Co.LtdShenzhen 518051Guangdong ProvinceChina Department of Stomatology The People’s Hospital of LonghuaShenzhen 518109Guangdong ProvinceChina Department of Stomatology The First Affiliated Hospital of Hainan Medical UniversityHaikou 570102Hainan ProvinceChina School of Stomatology Hainan Medical UniversityHaikou 571199Hainan ProvinceChina

Since dental pulp stem cells(DPSCs)were first reported,six types of dental SCs(DSCs)have been isolated and identified.DSCs originating from the craniofacial neural crest exhibit dental-like tissue differentiation potential and neuroectodermal features.As a member of DSCs,dental follicle SCs(DFSCs)are the only cell type obtained at the early developing stage of the tooth prior to eruption.Dental follicle tissue has the distinct advantage of large tissue volume compared with other dental tissues,which is a prerequisite for obtaining a sufficient number of cells to meet the needs of clinical applications.Furthermore,DFSCs exhibit a significantly higher cell proliferation rate,higher colony-formation capacity,and more primitive and better anti-inflammatory effects than other DSCs.In this respect,DFSCs have the potential to be of great clinical significance and translational value in oral and neurological diseases,with natural advantages based on their origin.Lastly,cryopreservation preserves the biological properties of DFSCs and enables them to be used as off-shelf products for clinical applications.This review summarizes and comments on the properties,application potential,and clinical transformation value of DFSCs,thereby inspiring novel perspectives in the future treatment of oral and neurological diseases.

关键词： Dental follicle stem cells Oral disease neurological disease Tissue engineering Regeneration Immunoregulation

Next generation of neurological therapeutics:Native and bioengineered extracellular vesicles derived from stem cells

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Journal of Pharmaceutical Sciences 2022年第6期17卷 779-797页

作者： Shilin Jin Zhongyue Lv Lin Kang Jiayi Wang Chengcheng Tan Liming Shen Liang Wang Jing Liu Stem Cell Clinical Research Center National Joint Engineering LaboratoryThe First Affiliated Hospital of Dalian Medical UniversityDalian 116011China Liaoning Key Laboratory of Frontier Technology of Stem Cell and Precision Medicine Dalian Engineering Research Center for Genetic Variation Detection of Infectious Pathogenic MicroorganismsDalian Innovation Institute of Stem Cell and Precision MedicineDalian 116085China

Extracellular vesicles(EVs)-based cell-free therapy,particularly stem cell-derived extracellular vesicles(SC-EVs),offers new insights into treating a series of neurological disorders and becomes a promising candidate for alternative stem cell regenerative therapy.Currently,SC-EVs are considered direct therapeutic agents by themselves and/or dynamic delivery systems as they have a similar regenerative capacity of stem cells to promote neurogenesis and can easily load many functional small molecules to recipient cells in the central nervous system.Meanwhile,as non-living entities,SC-EVs avoid the uncontrollability and manufacturability limitations of live stem cell products in vivo(e.g.,low survival rate,immune response,and tumorigenicity)and in vitro(e.g.,restricted sources,complex preparation processes,poor quality control,low storage,shipping instability,and ethical controversy)by strict quality control system.Moreover,SC-EVs can be engineered or designed to enhance further overall yield,increase bioactivity,improve targeting,and extend their half-life.Here,this review provides an overview on the biological properties of SC-EVs,and the current progress in the strategies of native or bioengineered SC-EVs for nerve injury repairing is presented.Then we further summarize the challenges of recent research and perspectives for successful clinical application to advance SC-EVs from bench to bedside in neurological diseases.

关键词： Extracellular vesicles Stem cells neurological disease Exosomes Bioengineer

Gut-brain axis:Focus on gut metabolites short-chain fatty acids

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2022年第6期10卷 1754-1763页

作者： Cen Guo Ya-Jing Huo Yu Li Yan Han Da Zhou Department of Neurology Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai 200437China Department of Gastroenterology and Hepatology Zhongshan HospitalFudan UniversityShanghai Institute of Liver DiseaseShanghai 200032China

Emerging evidence supports that the gut microbiome,reconsidered as a new organ in the human body,can not only affect the local gut,but also communicate with the brain via multiple pathways related to neuroendocrine,immune,and neural pathways,thereby proposing the new concept of the microbiome-gut-brain(MGB)axis.Recently,the role of short-chain fatty acids(SCFAs),which are the main anaerobic fermented metabolites of the gut microbiota in the MGB axis,has garnered significant attention.SCFAs are involved in a broad range of central neurological diseases,including neurodegenerative diseases,cerebral vascular diseases,epilepsy,neuroimmune inflammatory diseases,and mood disorders.However,the underlying mechanism of SCFA-related distant organ crosstalk is yet to be elucidated.Herein,we summarize current knowledge regarding interactions between SCFAs and the MGB axis,as well as their protective effects against central neurological diseases.

关键词： Gut-brain axis Short-chain fatty acids neurological disease Microbiome-gutbrain

Human TRMT1 catalyzes m^(2)G or(m^(2))_(2)G formation on tRNAs in a substrate-dependent manner

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2023年第10期66卷 2295-2309页

作者： Qing-Ping Xiong Jing Li Hao Li Zhi-Xuan Huang Han Dong En-Duo Wang Ru-Juan Liu State Key Laboratory of Molecular Biology CAS Center for Excellence in Molecular Cell ScienceShanghai Institute of Biochemistry and Cell BiologyChinese Academy of SciencesUniversity of Chinese Academy of SciencesShanghai 200031China School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China

TRMT1 is an N^2-methylguanosine(m^(2)G)and N^2,N^2-methylguanosine((m^(2))_(2)G)methyltransferase that targets G26 of both cytoplasmic and mitochondrial t RNAs.In higher eukaryotes,most cytoplasmic t RNAs with G26 carry(m^(2))_(2)G26,although the majority of mitochondrial G26-containing t RNAs carry m^(2)G26 or G26,suggesting differences in the mechanisms by which TRMT1 catalyzes modification of these t RNAs.Loss-of-function mutations of human TRMT1 result in neurological disorders and completely abrogate t RNA:(m^(2))_(2)G26 formation.However,the mechanism underlying the independent catalytic activity of human TRMT1 and identity of its specific substrate remain elusive,hindering a comprehensive understanding of the pathogenesis of neurological disorders caused by TRMT1 mutations.Here,we showed that human TRMT1 independently catalyzes formation of the t RNA:m^(2)G26 or(m^(2))_(2)G26 modification in a substrate-dependent manner,which explains the distinct distribution of m^(2)G26 and(m^(2))_(2)G26 on cytoplasmic and mitochondrial t RNAs.For human TRMT1-mediated t RNA:(m^(2))_(2)G26 formation,the semi-conserved C11:G24 serves as the determinant,and the U10:A25 or G10:C25 base pair is also required,while the size of the variable loop has no effect.We defined the requirements of this recognition mechanism as the“(m^(2))_(2)G26 criteria”.We found that the(m^(2))_(2)G26 modification occurred in almost all the higher eukaryotic t RNAs conforming to these criteria,suggesting the“(m^(2))_(2)G26 criteria”are applicable to other higher eukaryotic t RNAs.

关键词： RNA modification m^(2)G (m^(2))_(2)G tRNA TRMT1 neurological disease

Neuroprotective Effects of Molecular Hydrogen:A Critical Review

在线全文

学校读者我要写书评

暂无评论

Neuroscience Bulletin 2021年第3期37卷 389-404页

作者： Wei Chen Han-Ting Zhang Shu-Cun Qin Taishan Institute for Hydrogen Biomedicine Shandong First Medical University and Shandong Academy of Medical SciencesTai'an 271000China Key Laboratory of Atherosclerosis in Universities of Shandong and Institute of Atherosclerosis Shandong First Medical University and Shandong Academy of Medical SciencesTai’an 271000China Departments of Neuroscience and Behavioral Medicine and Psychiatry Rockefeller Neurosciences InstituteWest Virginia University Health Sciences CenterMorgantownWV 26506USA

Molecular hydrogen(H_(2))is a physiologically inert gas.However,during the last 10 years,increasing evidence has revealed its biological functions under pathological conditions.More specifically,H_(2) has protective effects against a variety of diseases,particularly nervous system disorders,which include ischemia/reperfusion injury,traumatic injury,subarachnoid hemorrhage,neuropathic pain,neurodegenerative diseases,cognitive dysfunction induced by surgery and anesthesia,anxiety,and depression.In addition,H_(2) plays protective roles mainly through anti-oxidation,anti-inflammation,antiapoptosis,the regulation of autophagy,and preservation of mitochondrial function and the blood-brain barrier.Further,H_(2) is easy to use and has neuroprotective effects with no major side-effects,indicating that H_(2) administration is a potential therapeutic strategy in clinical settings.Here we summarize the H_(2) donors and their pharmacokinetics.Meanwhile,we review the effectiveness and safety of H_(2) in the treatment of various nervous system diseasesbased on preclinical and clinical studies,leading to the conclusion that H_(2) can be a simple and effective clinical therapy for CNS diseases such as ischemia-reperfusion brain injury,Parkinson's disease,and diseases characterized by cognitive dysfunction.The potential mechanisms involved in the neuroprotective effect of H_(2) are also analyzed.

关键词： Molecular hydrogen(H_(2)) neurological disease Neuroprotection Anti-oxidation Anti-inflammation Anti-apoptosis

Green tea catechins inhibit microglial activation which prevents the development of neurological disorders

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2020年第10期15卷 1792-1798页

作者： Tahereh Farkhondeh Ali Mohammad Pourbagher-Shahri Milad Ashrafizadeh Silvia Llorens Folgado Ali Rajabpour-Sanati Mohammad Reza Khazdair Saeed Samarghandian Cardiovascular diseases Research Center Birjand University of Medical SciencesBirjandIran Faculty of Medicine Birjand University of Medical SciencesBirjandIran Department of Basic Science Faculty of Veterinary MedicineUniversity of TabrizTabrizIran Department of Medical Sciences Faculty of Medicine of AlbaceteCentro Regional de Investigaciones Biomedicas(CRIB)University of Castilla-La ManchaAlbaceteSpain Healthy Ageing Research Center Neyshabur University of Medical SciencesNeyshaburIran Department of Basic Medical Sciences Neyshabur University of Medical SciencesNeyshaburIran

The over-activated microglial cells induce neuroinflammation which has the main role in neurological disorders.The over-activated microglia can disturb neuronal function by releasing inflammatory mediators leading to neuronal dysfunctions and death.Thus,inhibition of over-activated microglia may be an effective therapeutic approach for modulating neuroinflammation.Experimental studies have indicated anti-neuroinflammatory effects of flavonoids such as green tea catechins.The current research was aimed to review the effect of green tea catechins in inhibiting microglial cells,inflammatory cascades,and subsequent neurological diseases.

关键词： catechins green tea microglia neuroinflammation neurological disease

The Jidong Eye Cohort Study:objectives,design,and baseline characteristics

在线全文

学校读者我要写书评

暂无评论

Eye and Vision 2020年第1期7卷 571-578页

作者： Kai Yang Lele Cui Guoyun Zhang Xianwei Wang Xiaoxuan Zhu Yunfan Xiao Binbin Su Daiyu Song Xinyao Zhang Yang Zheng Fan Lu Jia Qu Ming Li Eye Hospital and School of Ophthalmology and Optometry Wenzhou Medical UniversityWenzhouZhejiangChina National Clinical Research Center for Ocular diseases WenzhouZhejiangChina Dezhou Center for disease Control and Prevention DezhouShandongChina

Background:To describe the objective,design and baseline characteristics of the Jidong Eye Cohort Study(JECS),a community-based cohort in China based on etiology,imaging and biomarkers.The JECS will clarify the pathogenesis of visual impairment and status of ocular indicators in the occurrence and progression of cardiocerebrovascular and neurological diseases.Methods:Between August 2019 and January 2020,the JECS recruited consecutive participants aged 18 years and older from the Jidong communities in China.The demographic and clinical characteristics were collected by trained site personnel via face-to-face interviews.The relevant biological samples were also collected.The participants underwent comprehensive ophthalmic examination,such as retinal photography and optical coherence tomography(OCT)angiography.The following outcomes were measured annually:ocular vascular abnormality,optic nerve degeneration,cardiovascular diseases(CVD)and neurological diseases.The study will be performed until 2024.Results:Among 3377 participants,the average age was 45.0±12.5 years and 1809(53.6%)were women.Hypertension occurred in 825 individuals(25.0%),diabetes in 258(7.7%),hyperglycemia in 474(14.2%),and a CVD history in 100(3.0%).The mean best-corrected visual acuity was 0.1 logMAR in the recruited subjects.The average OCT signal index was 8.2±1.2.Additionally,the mean vessel densities for the entire measured area were 46.4%and 50.8%for the superficial and deep vascular complex,respectively.Mean area and perimeter of foveal avascular zone was 0.3 mm2 and 2.3 mm.Conclusions:The JECS is a large community-based prospective cohort in North China.Rich data collected from this study will provide the opportunity to identify risk factors,imaging,and biomarkers of visual impairment(either ocular vascular anomalies or optic nerve degeneration)and to evaluate their associations with CVD and neurological diseases.

关键词： Cohort Risk factor Visual impairment Cardiovascular disease neurological disease Epidemiology