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Neuroinmunological response in HIV-associated Guillain-Barre syndrome: A case report

World Journal of Neuroscience 2012年第1期2卷 32-35页

作者： Ivonne M. Iglesias-González Alberto J. Dorta-Contreras Bárbara Padilla-Docal Maylin Victoria-Garcia Ricardo Junco-Calzadilla Faculty of Medical Sciences “Dr Miguel Enríquez” Central Laboratory of Cerebrospinal Fluid (LABCEL) Havana Medical Sciences University Havana City Cuba Raúl Gómez García Hospital Havana City Cuba

Introduction: Human immunodeficiency virus infec- tion is associated with several different types of peripheral neuropathy: distal predominantly sensory axonal polyneuropathy, like Guillain Barre syndrome. Case presentation: A 55-year-old Caucasian woman with Human immunodeficiency virus infection, diag- nosed with Guillain Barre syndrome was studied. Serum and CSF immunoglobulin G and Albumin levels were quantified by using an immunodiffusion technique. She had preceding viral symptoms. The clinical diagnosis of the illness in this patient was pa-resthesias or sensory loss, tendon reflexes. It was also observed cranial nerves abnormalities, acute mo- tor and sensory axonal neuropathy and ophthalmoplegia. The mean CD4 count was 367/mm3, CSF white blood cell 25 wbc/mm3. The serum sodium concentration was significantly low (133 mmol/L). She had a respiratory compromise as a result of their neuropa- thy and developed congestive heart failure and hy- potension and died of a cardiac arrest. The neuro-immunological response described by our patient was a blood/CSF barrier dysfunction without IgG intra-thecal synthesis. Conclusion: There is no doubt that this study is of great importance because will help clinicians increase their knowledge of the immune response in patients with this autoimmune disorder on the basis of this case report, in which, for first time, could be seen the neuroimmunological response through the reibergram in a patient with HIV- asso-ciated Guillain-Barre syndrome.

关键词： Guillain Barre Human Immunodeficiency Virus neuroimmunological Response Blood/CSF

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