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neurogenic pulmonary edema after Subarachnoid Hemorrhage

镜湖医学 2007年第1期7卷 49-51页

作者：李昱暉郭有方黎啟盛甘麗好澳門鏡湖醫院急診科中国

neurogenic pulmonary edema(NPE)is a well known complication of severe central nervous system insult,such as subarachnoid hemorrhage(SAH).Endogenous catecholamines can result in ***-respira-tory dysfunction may present severer than the clinical symptom of *** management for patients with NPE after SAH is *** describe a patient with NPE after *** rapid development of respiratory and cardiac impairment had masked the initial disease.

关键词： neurogenic pulmonary edema subarachnoid hemorrhage catecholamines

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Clinical characteristics and treatment of severe encephalitis associated with neurogenic pulmonary edema caused by enterovirus 71 in China

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World Journal of Emergency Medicine 2010年第2期1卷 108-113页

作者： Yu-cai Zhang Xing-wang Li Xiao-dong Zhu Su-yun Qian Yun-xiao Shang Bi-ru Li Xiao-lin Liu Children's Hospital Shanghai Jiaotong University Shanghai 200040 China Beijing Ditan Hospital Beijing 100010 China Xinhua Hospital Shanghai Jiaotong University School of Medicine Shanghai 200092 China Beijing Children's Hospital Beijing 100045 China Shengjing Hospital China Medical University Shenyang 110004 China Children Medical Center Shanghai Jiaotong University School of MedicineShanghai 200127 China People's Hospital of Fuyang City Fuyang 236004 China

BACKGROUND:Hand-foot-mouth disease has become a major public health issue in children in China. In the present prospective study we investigated the clinical characteristics and emergency management of children with severe encephalitis associated with NPE caused by enterovirus 71.;METHODS:The study was conducted in 2 pediatric intensive care units (PICUs) over a 2-month period. Clinical records were reviewed of critically ill children with severe encephalitis associated with NPE caused by EV71 who were admitted to PICUs during the period of May to June 2008 in Fuyang.;RESULTS:We reviewed the complete records of 36 children, of whom 23 (63.9%) were male and 13 (36.1%) female. Their age ranged from 4 to 48 months, with an average of 15.8 months. All children except one were under 3 years of age. The overall mortality in these children was 19.4%. The average duration of critical life threatening signs and symptoms was 2.1 days (12 hours-5 days). Nervous system diseases included brainstem encephalitis in 27 children (75%), brainstem encephalitis associated with myelitis in 6 children (16.7%), and general encephalitis in 3 chidren (8.3%), respectively. In 12 patients of NPE (33.3%) pink or bloody bubble sputum and asymmetric pulmonary edema or hemorrhage was the primary manifestation but no typical exanthema was observed. Five children died of acute onset of NPE and / or pulmonary hemorrhage with rapid progression of cardiopulmonary failure within hours after admission. Therapeutic management consisted of mechanical ventilation and administration of mannitol, methylprednisolone, intravenous immunoglobulin (IVIG) and vasoactive drugs, associated with the need of fluid volume resuscitation in 9 (25%) of the 36 children.;CONCLUSIONS:In children less than 3 years of age found to be affected by severe EV71 encephalitis associated with NPE, one fifth may die. The major organ systems infected by severe EV71 include the central nervous system, the respiratory system, and the car

关键词： Child Encephalitis Enterovirus71 (EV71) Hand-foot-mouth disease neurogenic pulmonary edema

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A pH-dependent molecular switch for virion uncoating

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Protein & Cell 2014年第9期5卷 653-654页

作者： Satoshi Koike Neurovirology Project Tokyo Metropolitan Institute of Medical Science 2-1-6 Kamikitazawa Setagaya-ku Tokyo 156-8506Japan

Enterovirus 71, belonging to human enterovirus speCies A in the genus Enterovirus of the family Picornaviridae, is one of the main causative agents of hand-foot-mouth disease. It can also cause severe neurological diseases such as acute encephalitis, polio-like paralysis, and neurogenic pulmonary edema, and it has become a serious public health concern especially in the Asia-Pacific region.

关键词： Capsid Protein EV71 Infection Lysosomal Compartment neurogenic pulmonary edema Native Virion

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Neutrophil Extracellular Traps may be a potential therapeutic target in Subarachnoid Hemorrhage

Neutrophil Extracellular Traps may be a potential therapeuti...

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第十六届中国医师协会神经外科医师年会

Objective:Neuroinflammation is closely related to poor prognosis in patients with subarachnoid hemorrhage(SAH).The purpose of this study was to investigate the role of neutrophil extracellular traps(NETs) in SAH,which were important regulators of sterile ***:Plasma from SAH patients and health checkups were used for Elisa *** C57BL/6 mice were used to set up SAH *** peptidyl arginine deiminase 4(PAD4) selective antagonist GSK484,an effective NETs inhibitor,was administered daily(3 days before SAH).Meanwhile,DNAse I treatment and neutrophil depletion were performed to confirm the benefit from the inhibition of *** evaluation of post-SAH included SAH grade,neurological test,brain water content,western blotting,quantitative realtime polymerase chain reaction and ***:NETs formation,quantified by the level of CitH3,was increased significantly after SAH of patients and *** reached the peak at 12 hours in peripheral blood and at 24 hours in *** of GSK484 substantially attenuated SAH-induced brain edema and neuronal ***,the benefit from the inhibition of NETs was also confirmed by DNAse I treatment and neutrophil ***,neurogenic pulmonary edema(NPE),one of severe non-neurological complications after SAH was witnessed with high level of NETs formation as *** GSK484,DNAse I or neutrophil depletion could inhibit the formation of NETs in the lung of NPE effectively,thereby prevent the diffusion of neutrophilic infiltration and attenuated swelling of the alveolar ***:NETs promoted neuroinflammation after SAH,while pharmacologic inhibition of NETs could reduce the inflammatory damage caused by *** data supported the idea that the NETs might be the potential therapeutic target for SAH.

关键词： Subarachnoid hemorrhage Neutrophil extracellular traps Microglia Neuroinflammation neurogenic pulmonary edema

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