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Neuroendocrine gastric carcinoma expressing somatostatin: A highly malignant, rare tumor

World Journal of Gastroenterology 2006年第24期12卷 3944-3947页

作者： Jaques Waisberg Leandro Luongo de Matos Ana Maria do Amaral Antonio Mader Sérgio Pezzolo Esmeralda Miristene Eher Vera Luiza Capelozzi Manlio Basilio Speranzini Department of Surgery Faculty of Medicine of ABC Santo AndréBrazil Faculty of Medicine of ABC Santo André S(a|~)o PauloBrazil Department of Pathology Faculty of Medicine of ABC Santo AndréBrazil Department of Pathology Faculty of Medicine S(a|~)o Paulo UniversityBrazil

Poorly differentiated gastric neuroendocrine carcinomas, although rare, deserve particular attention, as they are aggressive and have an extremely poor prognosis. In this report we describe a gastric neuroendocrine carcinoma with rapidly fatal outcome. Immunohistological staining of the resected specimens revealed that the tumor was an endocrine carcinoma. The tumor disclosed intense immunoreactivity to pan-neuroendocrine markers and diffuse somatostatin immunoreactivity. There were no psammoma bodies and no demonstrable association with yon Recklinghausen＇s neurofibromatosis. In the gastrointestinal tract, neuroendocrine tumors producing predominantly somatostatin have been described only in the duodenum. To the best of our knowledge, the present report is the second case report of a neuroendocrine gastric carcinoma expressing diffusely somatostatin as the only neuroendocrine regulatory peptide.

关键词： Neuroendocrine carcinoma neuroendocrinetumors Carcinoid Stomach neoplasms Somatostatin Immunohistochemistry Tumor markers Enterochromaffin-like cells

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Endoscopic ultrasound guided radiofrequency ablation,for pancreatic cystic neoplasms and neuroendocrine tumors

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World Journal of Gastrointestinal Surgery 2015年第4期7卷 52-59页

作者： Madhava Pai Nagy Habib Hakan Senturk Sundeep Lakhtakia Nageshwar Reddy Vito R Cicinnati Iyad Kaba Susanne Beckebaum Panagiotis Drymousis Michel Kahaleh William Brugge HPB Unit Hammersmith HospitalImperial College Emcision Limited Department of Gastroenterology Bezmi Alem University Asian Institute of Gastroenterology Department of Transplant Medicine University Hospital Münster Division of Gastroenterology and Hepatology Department of MedicineWeill Cornell Medical College Massachusetts General Hospital Harvard Medical School

AIM: To outline the feasibility, safety, adverse events and early results of endoscopic ultrasound(EUS)-radiofrequency ablation(RFA) in pancreatic neoplasms using a novel probe. METHODS: This is a multi-center, pilot safety feasibility study. The intervention described was radiofrequency ablation(RF) which was applied with an innovative monopolar RF probe(1.2 mm Habib EUS-RFA catheter) placed through a 19 or 22 gauge fine needle aspiration(FNA) needle once FNA was performed in patients with a tumor in the head of the pancreas. The HabibTM EUSRFA is a 1 Fr wire(0.33 mm, 0.013") with a working length of 190 cm, which can be inserted through the biopsy channel of an echoendoscope. RF power is applied to the electrode at the end of the wire to coagulate tissue in the liver and ***: Eight patients [median age of 65(range 27-82) years; 7 female and 1 male] were recruited in a prospective multicenter trial. Six had a pancreatic cysticneoplasm(four a mucinous cyst, one had intraductal papillary mucinous neoplasm and one a microcystic adenoma) and two had a neuroendocrine tumors(NET) in the head of pancreas. The mean size of the cystic neoplasm and NET were 36.5 mm(SD ± 17.9 mm) and 27.5 mm(SD ± 17.7 mm) respectively. The EUSRFA was successfully completed in all cases. Among the 6 patients with a cystic neoplasm, post procedure imaging in 3-6 mo showed complete resolution of the cysts in 2 cases, whilst in three more there was a 48.4% reduction [mean pre RF 38.8 mm(SD ± 21.7 mm) vs mean post RF 20 mm(SD ± 17.1 mm)] in size. In regards to the NET patients, there was a change in vascularity and central necrosis after EUS-RFA. No major complications were observed within 48 h of the procedure. Two patients had mild abdominal pain that resolved within 3 d. CONCLUSION: EUS-RFA of pancreatic neoplasms with a novel monopolar RF probe was well tolerated in all cases. Our preliminary data suggest that the procedure is straightforward and safe. The response ranged from com

关键词： Endoscopic ultrasound Radiofrequencyablation Pancreas Cystic neoplasms neuroendocrinetumors

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