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Overview of angiogenesis and oxidative stress in cancer

World Journal of Meta-Analysis 2023年第6期11卷 253-265页

作者： Luigi Gaetano Andriolo Vittoria Cammisotto Alessandra Spagnoli Danilo Alunni Fegatelli Michele Chicone Gaetano Di Rienzo Vladimiro Dell’Anna Giambattista Lobreglio Giovanni Serio Pasquale Pignatelli Department of General and Specialistic Surgery Paride Stefanini Policlinico Umberto IUniversity of Rome SapienzaRome 06100Italy UnitàOperativa Complessa Chirurgia Toracica Ospedale Vito FazziLecce 73100Italy Department of Clinical Internal Anaesthesiological and Cardiovascular SciencesUniversity of Rome SapienzaRome 06100Italy Department of Public Health and Infectious Diseases University of Rome SapienzaRome 06100Italy Department of Clinical Pathology and Microbiology Ospedale Vito FazziLecce 73100Italy Pathological Anatomy Unit Ospedale Vito FazziLecce 73100Italy

Neoplasms can be considered as a group of aberrant cells that need more vascular supply to fulfill all their ***,they promote angiogenesis through the same neovascularization pathway used *** is a process characterized by a heterogeneous distribution of oxygen caused by the tumor and oxidative stress;the latter being one of the most powerful stimuli of *** a result of altered tumor metabolism due to hypoxia,acidosis *** angiogenic process and oxidative stress can be detected by measuring serum and tissue *** study of the mechanisms underlying angiogenesis and oxidative stress could lead to the identification of new biomarkers,ameliorating the selection of patients with neoplasms and the prediction of their response to possible anti-tumor *** particular,in the treatment of patients with similar clinical tumor phenotypes but different prognoses,the new biomarkers could be ***,they may lead to a better understanding of the mechanisms underlying drug *** studies show that blocking the vascular supply results in antiproliferative activity in vivo in neuroendocrine tumor cells,which require a high vascular supply.

关键词： neuroendocrine lung tumors Angiogenesis Oxidative stress neuroendocrine serum markers neuroendocrine tissue markers Future therapy

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