检索结果-南通市图书馆

Neurotoxicity of tetramethylammonium ion on larval and juvenile zebrafish:Effects on neurobehaviors and multiple biomarkers

引用

Journal of Environmental Sciences 2024年第9期143卷 138-147页

作者： Ruixin Zhang Rui Wang Jiajun Chang GDaniel Sheng Daqiang Yin Key Laboratory of Yangtze River Water Environment Ministry of EducationCollege of Environmental Science and EngineeringTongji UniversityShanghai 200092China Shanghai Institute of Pollution Control and Ecological Security Shanghai 200092China

Tetramethylammonium hydroxide(TMAH)is an important compound that utilized and released by the rapidly expanding semiconductor industry,which could hardly be removed by the conventional wastewater treatment *** a cholinergic agonist,the tetramethylammonium ion(TMA^(+))has been reported to induce toxicity to muscular and respiratory systems of mammals and human,however the toxicity on aquatic biota remains poorly *** investigated the neurotoxic effects of TMA^(+)exposure on zebrafish,based on neurobehavior tests and a series of *** inhibitions on the swimming distance of zebrafish larvae were observed when the exposure level exceeded 50 mg/L,and significant alterations on swimming path angles(straight and deflective movements)occurred even at 10 mg/*** tested neurobehavioral endpoints of zebrafish larvae were significantly positively correlated with reactive oxygen species(ROS)and malondialdehyde(MDA),significantly negatively related with the activities of antioxidant enzymes,but not significantly correlated with the level of acetylcholinesterase(AChE).Such relationship indicates that the observed neurotoxic effects on swimming behavior of zebrafish larvae is mainly driven by oxidative stress,rather than the alterations of *** the highest exposure concentration(200 mg/L),TMA^(+)evoked more severe toxicity on zebrafish juveniles,showing significantly stronger elevation on the MDA activity,and greater inhibitions on the activities of antioxidant enzymes and ACh E,suggesting juveniles were more susceptible to TMA^(+)exposure than larval zebrafish.

关键词： Tetramethylammonium Zebrafish Oxidative stress Acetylcholinesterase neurobehavior

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

neurobehavioral Assessment of Rats Exposed to Yttrium Nitrate during Development

引用

Biomedical and Environmental Sciences 2015年第4期28卷 281-290页

作者： LI Chen Xi MA Chuan FANG Hai Qin ZHI Yuan YU Zhou XU Hai Bin JIA Xu Dong National Institute for Nutrition and Food Safety Chinese Center for Disease Control and Prevention Key Laboratory of Food Safety Risk Assessment of Ministry of Health China National Center for Food Safety Risk Assessment

Objective The aim of this study was to assess the effects of yttrium nitrate on neurobehaviora development in Sprague-Dawley rats. Methods Dams were orally exposed to 0, 5, 15, or 45 mg/kg daily of yttrium nitrate from gestation day （GD） 6 to postnatal day （PND） 21. Body weight and food consumption were monitored weekly. neurobehavior was assessed by developmental landmarks and reflexes, motor activity, hot plate, Rota-rod and cognitive tests. Additionally, brain weights were measured on PND 21 and 70. Results No significant difference was noted among all groups for maternal body weight and food consumption. All yttrium-exposed offspring showed an increase in body weight on PND 21; however, no significant difference in body weight for exposed pups versus controls was observed 2 weeks or more after the yttrium solution was discontinued. The groups given 5 mg/kg daily decreased significantly in the duration of female forelime grip strength and ambulation on PND 13. There was no significant difference between yttrium-exposed offspring and controls with respect to other behavioral ontogeny parameters and postnatal behavioral test results. Conclusion Exposure of rats to yttrium nitrate in concentrations up to 45 mg/kg daily had no adverse effects on their neurobehavioral development.

关键词： Rare earth elements Yttrium Developmental neurotoxicity neurobehavior

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Tetrabromobisphenol A exerts thyroid disrupting effects but has little overt impact on postnatal brain development and neurobehaviors in mice

引用

Journal of Environmental Sciences 2024年第8期142卷 1-10页

作者： Shilin Song Yuanyuan Li Lin Lv Mengqi Dong Zhanfen Qin State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China College of Resources and Environment University of Chinese Academy of SciencesBeijing 100049China School of Environment Tsinghua UniversityBeijing 100084China

Tetrabromobisphenol A(TBBPA)is a widely used brominated flame *** is evidence showing that TBBPA can exert thyroid disrupting effects in mammals,but different results were also reported,along with inconsistent reports regarding its ***,we investigated thyroid disrupting effects and neurotoxicity of TBBPA(5,50,500μg/(kg·day))to male mice following maternal and direct exposure through drinking water,with the antithyroid drug propylthiouracil(PTU)as the positive *** postnatal day(PND)15,we expectedly observed severe thyroid compensatory hyperplasia and cerebellar developmental retardation in PTU-treated *** highest dose of TBBPA also caused thyroid histological alteration but had no effects on cerebellar development in terms of Purkinje cell morphology and the thickness of the internal granular layer and the molecular layer of the *** puberty and adulthood,the thyroid morphological alterations became more pronounced in the TBBPA-treated animals,accompanied by decreased serum thyroid hormone ***,the 50 and 500μg/(kg·day)TBBPA groups showed a significant decrease in the serum level of serotonin,a neurotransmitter associated with anxiety ***,the highest dose group displayed anxiety-like behaviors in the elevated plus-maze test on PND 35,but this neurobehavioral alteration disappeared on PND ***,no changes in neurobehavioral parameters tested were found in TBBPAtreated animals at puberty and ***,all observations show that TBBPA can exert thyroid disrupting effects but has little overt impact on brain development and neurobehaviors in mice,suggesting that thyroid disruption does not necessarily cause overtly adverse neurodevelopmental outcomes.

关键词： Tetrabromobisphenol A Thyroid disruption Brain development neurobehavior Cerebellum

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

NP-8 Moderate Brain Injury Causes neurobehavioral Deficits and Effects of Aerobic Exercise

引用

神经药理学报 2018年第4期8卷 106-107页

作者： WANG Ji-hui FAN Zhi-heng PAN Hui-ju OU Yang-wei College of Physical Education and Health SciencesZhejiang Normal UniversityJinhua3210004China

Objective:Moderate traumatic brain injury(TBI)can lead to a lifetime of physical,cognitive,emotional,and behavioral ***,the secondary brain injury(SBI)during subacute and chronic phase after TBI could be blamed for these *** is widely recognized as promoting health and improving bad moods,but the mechanisms by which exercise affects SBI are still ***:Lateral fluid percussion(LFP)method was used to fabricate moderate TBI in motor and somatosensory cortex of the C57 BL/6 J mice.A 4-weeks voluntary running wheel exercise with 6-day training per week was modified based on the previous *** status,sensorimotor function,spatial memory,electrophysiological,post-traumatic stress disorder(PTSD)associated anxiety and depression,cortical pathohistological changes were assessed to evaluate effects TBI and exercise ***:After moderate LFP injury,the TBI mice showed severe motor deficits at the early stage in acute phase but gradually *** acute and subacute phase after TBI,novel object recognition(NOR)ability and spatial memory functions were consistently impaired in TBI mice;hippocampal firing frequency and burst probability were *** of the altered burst firing shows a clear hippocampal theta rhythm *** electrophysiological impacts were associated with substantially lowered NOR preference as compared with the sham group during adulthood.4-weeks voluntary wheel running performed prior to induction of a moderate TBI,combined with 2 weeks voluntary motor skill training after TBI was found to inhibit plasma TNF-α,improve locomotor activity levels,alleviate anxiety and depression and promote spatial working memory recovery in *** the meantime,histopathological deterioration was eased in the hippocampus in exercised ***:moderate TBI could induce neurological and neurobehavior impairments in *** exercise rehabilitation alleviated above mentioned deficit

关键词： traumatic brain injury neurobehavior deficits electrophysiological changes aerobic exercise

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Relationship Between Low-Level Lead Exposure and neurobehaviors of Preschool Children

引用

中国当代儿科杂志 2002年第4期 345-347页

作者： LIU Jian An, LIU De Hua, JING Jin, YI Huan Qiong, WANG Meng Long, CHEN Xue Bin(School of Public Health, Sun Yat sen University of Medical Sciences, Guangzhou 510089, China)

Objective To study the effects of exposure to low level lead on neurobehaviors of preschool children. Methods Blood lead levels were measured in 211 preschool children aged 4-6 years in a kindergarten without known exposure to lead sources; the 211 children were assigned into two groups: low blood lead level group (LL group, neurobehaviors were assessed with Achenbach child behavior checklist (CBCL) to study the relationship between blood lead and CBCL total behavior scores (TBPs), internalizing and externalizing scores (Ints and Exts). Results The Exts and incidence of abnormal behavior problems in the HL group ( 13.28 ± 6.26 and 18.26% , respectively) were much higher than those in the LL group ( 9.98 ± 5.46 and 7.29% , respectively)(t= 4.0677 , χ 2= 5.470 , Pneurobehaviors of preschool children.

关键词： Low level lead exposure neurobehavior Child

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Compound Formula Rehmannia alleviates levodopainduced dyskinesia in Parkinson's disease

引用

Neural Regeneration Research 2014年第4期9卷 407-412页

作者： Long Teng Fang Hong Chenguang Zhang Jiancheng He Haiying Wang Shanghai University of Traditional Chinese Medicine

Compound Formula Rehmannia has been shown to be clinically effective in treating Parkinson＇s disease and levodopa-induced dyskinesia; however, the mechanisms remain unclear. In this study, we established a model of Parkinson＇s disease dyskinesia in rats, and treated these animals with Compound Formula Rehmannia. Compound Formula Rehmannia inhibited the increase in mRNA expression of N-methyl-D-aspartate receptor subunits 1 and 2 and excitatory amino acid neurotransmitter genes, and it inhibited the reduction in expression of γ-aminobutyric acid receptor B1, an inhibitory amino acid neurotransmitter gene, in the corpus striatum. In addition, Compound Formula Rehmannia alleviated dyskinesia symptoms in the Parkinson＇s disease rats. These experimental findings indicate that Compound Formula Rehmannia alleviates levodopa-induced dyskinesia in Parkinson＇s disease by modulating neurotransmitter signaling in the corpus striatum.

关键词： nerve regeneration traditional Chinese medicine Parkinson's disease dyskinesia excitato-ry amino acid inhibitory amino acid neurobehavior Compound Formula Rehmannia NSFC grant neural regeneration

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The protective effect of W026B on global cerebral ischemia/reperfusion injury model in rats

引用

Journal of Chinese Pharmaceutical Sciences 2022年第2期31卷 108-116页

作者： Ziyi Wang Xiaoyan Liu Yuanjun Zhu Ye Liu Pingping Zhang Yinye Wang Department of Molecular and Cellular Pharmacology School of Pharmaceutical SciencesPeking University Health Science CenterBeijing 100191China Beijing Honghui New Medical Technology Co. Ltd.Beijing Daxing Biological Medicine Industry BaseBeijing 102600China

Cerebral ischemia seriously affects the quality of life and health of human worldwide.W026B is a newly synthesized lignan derivative that has a protective effect on the focal cerebral ischemia/reperfusion model,while it is unclear whether W026B has a cerebral protective effect on the model of global cerebral ischemia/reperfusion(GCI/R).In this study,we investigated the protective effect of W026B on the four-vessel occlusion GCI/R *** results showed that W026B obviously increased the survival rate of rats during 7 d after GCI/R and significantly improved neurological deficits within 7 d after GCI/*** evidently enhanced the number of survival neurons in the hippocampus of GCI/R ***,W026B notably lowered the level of ROS,and increased the activity of SOD in the hippocampus of GCI/R ***,it also decreased the expression of NF-κB p65 and the level of IL-6 *** addition,W026B evidently lowered the activity of *** conclusion,this study firstly proves that W026B has the protective effect on GCI/R *** cerebral protective effect maybe related to the inhibition of oxidative stress,inflammatory response,and cell apoptosis during GCI/*** results provide new evidence with the protective effect of W026B on cerebral ischemia/reperfusion injury.

关键词： Global cerebral ischemia/reperfusion W026B neurobehavior Oxidative stress Inflammation Apoptosis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Oral Amodiaquine, Artesunate and Artesunate Amodiaquine Combination Affects Open Field Behaviors and Spatial Memory in Healthy Swiss Mice

引用

Journal of Behavioral and Brain Science 2013年第8期3卷 569-575页

作者： Adejoke Yetunde Onaolapo Olakunle James Onaolapo Emmanuel O. Awe Samuel Oloyede Ayomide Joel Department of Human Anatomy Faculty of Basic Medical Sciences College of Health Sciences Ladoke Akintola University Ogbomoso Nigeria Department of Pharmacology Faculty of Basic Medical Sciences College of Health Sciences Ladoke Akintola University Oshogbo Nigeria

Effects of amodiaquine, artesunate and artesunate amodiaquine combination on open field novelty-induced behaviors and spatial memory in healthy mice were studied. Forty mice were used in the open field and fifty each in the radial arm maze and Y maze;mice were assigned into four or five groups of ten each, Group A served as control (distilled water), Groups B, C and D received artesunate (4 mg/kg), amodiaquine (10 mg/kg) and artesunate-amodiaquine combination (4 mg/kg and10 mg/kg) respectively, while Group E animals (for the cognition tests) were given scopolamine (2 mg/kg). Drugs and vehicle were administered orally for three days. Results were analysed by one way analysis of variance followed by a posthoc test. Results showed that artesunate and amodiaquine either in combination or administered singly caused a significant increase in open field novelty-induced horizontal locomotion and rearing. Grooming in the open field showed increments in the artesunate alone and artesunate amodiaquine groups while significant reductions in spatial memory were also seen in the cognition models used.

关键词： neurobehavior Artesunate Amodiaquine Antimalaria Novelty-Induced Behaviors Cognition

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Developmental effects of Malathion exposure on locomotor activity and anxiety-like behavior in Wistar rat

引用

Health 2013年第3期5卷 603-611页

作者： Pacome Kouadio N’Go Fatima-Zahra Azzaoui Ahmed Omar Touhami Ahami Porlo Rigobert Soro Mohamed Najimi Fatiha Chigr Unit of Clinic and Cognitive Neuroscience Laboratory of Biology and HealthDepartment of BiologyFaculty of SciencesIBN TOFAILUniversityKenitraMorocco Laboratory of Animal Physiology Department of BiologyFaculty of Sciences and TechnologySultan Moulay Slimane UniversityBeni MellalMorocco

Developmental exposure to organophosphate insecticide is well known to induce neurobeha-vioral impairments, at late period. The present study aims to investigate the effects of chronic exposure to Malathion, from in utero to young adult stage, on locomotor skills and anxiety like- behavior among wistar rat. Four groups of female rats, bred with one non-pesticide exposed male, are used. On gestational day 6, three groups receive daily, by intragastric gavage, 3 different doses of Malathion dissolved in corn oil (100, 200 and 300 mg/kg body weight). The control group receives the corn oil only. On postnatal day 21, weaned offsprings are submitted to the similar treatment until adult age. Spontaneous locomotor activity is evaluated using the Open-Field test (OF) and anxiety-like behavior is measured using both Open-Field (OF) test and Elevate Plus-Maze (EPM). Malathion at 300 mg/kg is toxic to pregnant dams, and pups are stillborns. In males, Malathionlevelat 100 and 200 mg/kg induced significant impairment of spontaneous locomotor activities, which is reflected by high decrease of number of squares crossed in OF. In contrast, no discernible changes are observed within females Malathion-treated-group. However, females exposed to both malathion levels develop further anxiety-like response, expressed by significant reductions of exploratory activities in OF and time spent in open arm of EPM. Neurochemistry assay shows that cerebellum and neocortex acetylcholinesterase (AChE) activity inhibition are significantly increased with neurobehavioral deficits in males, relative to females. Overall, neurobehavioral outcomes of current study reveal that developmental exposure to Malathion induces sex-selective effects with greater changes in females.

关键词： AChE Activity Developmental Neurotoxicity Malathion neurobehavior Organophosphate Insecticides

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effects of Dimethoate Exposure on Locomotor Activity and Anxiety-Like Behavior in Female Wistar Rat

引用

Journal of Behavioral and Brain Science 2017年第10期7卷 484-496页

作者： Majda Samih Pacome Kouadio N’Go Sabah Belaaouja Amina Ouazzani Touhami Ahmed Omar Touhami Ahami Unit of Clinic and Cognitive Neuroscience Laboratory of Biology and HealthDepartment of BiologyFaculty of SciencesIBN TOFAIL UniversityKenitraMorocco Training and Research Unit of Biology Sciences Peleforo Gon Coulibaly University of KorhogoKorhogoIvory Coast Botanical and Plant Protection Unit Laboratory of Biology and HealthDepartment of BiologyFaculty of SciencesIbn Tofail UniversityKenitraMorocco

Developmental exposure to organophosphate insecticide is well known to induce neurobehavioral impairments, at late period. The present study aims to investigate the effects of subchronic exposure to Dimethoate, on locomotors skills and anxiety like behavior among wistar rat. Two groups of female’s rats are used. The intoxicated group receives daily, during five weeks, by intragastric gavage, a dose of Dimethoate dissolved in corn oil (100 mg/kg body weight). The control group receives only the corn oil. Spontaneous locomotors activity is evaluated using the Open Field test (OF) and anxiety-like behavior is measured using Elevated Plus-Maze (EPM). Dimethoate induced significant impairment of spontaneous locomotors activities, which is reflected by high decrease of number of squares crossed (SC) in OF. Females exposed to Dimethoate develop further anxiety-like response, expressed by significant reductions of the time spent in open arm of Elevated Plus-Maze.

关键词： Acetylcholinesterase Activity Neurotoxicity Dimethoate neurobehavior Organophosphate Insecticides

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：