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Frontiers and future perspectives of neuroimmunology

Fundamental Research 2024年第2期4卷 206-217页

作者： Hai Qi Shumin Duan Yanying Xu Hongliang Zhang School of Medicine Tsinghua UniversityBeijing 100084China Faculty of Medicine and Pharmaceutical Sciences Zhejiang UniversityHangzhou 310014China Department of Life Sciences National Natural Science Foundation of ChinaBeijing 100085China

neuroimmunology is an interdisciplinary branch of biomedical science that emerges from the intersection of studies on the nervous system and the immune system.The complex interplay between the two systems has long been recognized.Research efforts directed at the underlying functional interface and associated pathophysiology,however,have garnered attention only in recent decades.In this narrative review,we highlight significant advances in research on neuroimmune interplay and modulation.A particular focus is on early-and middle-career neuroimmunologists in China and their achievements in frontier areas of"neuroimmune interface","neuro-endocrine-immune network and modulation","neuroimmune interactions in diseases","meningeal lymphatic and glymphatic systems in health and disease",and"tools and methodologies in neuroimmunology research".Key scientific questions and future directions for potential breakthroughs in neuroimmunology research are proposed.

关键词： neuroimmunology neuroimmune interplay neuro-endocrine-immune network Basic research Key scientific questions

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Current Tracking on Effectiveness and Mechanisms of Acupuncture Therapy: A Literature Review of High-Quality Studies

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Chinese Journal of Integrative Medicine 2020年第4期26卷 310-320页

作者： YANG Fu-ming YAO Lin WANG Shen-jun GUO Yi XU Zhi-fang ZHANG Chien-Hung ZHANG Kuo FANG Yu-xin LIU Yang-yang Acupuncture Research Center Tianjin University of Traditional Chinese MedicineTianjin(301617)China Department of Acu-moxibustion and Tuina Changchun University of Traditional Chinese MedicineJilin(130000)China Department of Acu-moxibustion and Tuina Tianjin University of Traditional Chinese MedicineTianjin(301617)China Department of Traditional Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin(301617)China

The scientific evidenee of acupuncture studies has been improved in recent years,and one of the important manifestations is that more and more acupuncture clinical trials and mechanism researches have been published in the source periodicals of Science Citation Index(SCI).This study summarized the dominant diseases of acupuncture focusing on of acupuncture efficacy and mechanisms,and discussed the existing problems,highlight!ng the directi on of future developme nts.Most clinical studies were published in journals with journal impact factor(JIF)score of 10 or above,and majority of the basic researches had JIF scores of 5 to 10.The above literature were further divided according to the International Classification of Diseases(ICD).The most concerned diseases in these articles were neurological diseases,musculoskeletal system and connective tissue diseases,tumor and digestive system diseases.The therapeutic effect and mechanism of acupuncture on each kind of disease were summarized.The results showed that the therapeutic effect of acupuncture on nerve injury focused on the anti-oxidation pathway,neuroprotective and anti-inflammatory processes.The antiinflammatory effect also played an important role in the treatme nt of musculoskeletal diseases.The an algesic effect was underlined in most of these studies.Clinical trials were well carried out on acupuncture curative effect of tumor complications and side effects of chemo-radiotherapy,but the potential mechanisms have not been clarified.Somato-visceral reflex was suggested to be strongly associated with the effects of acupuncture changing the motor activity of the gastrointestinal tract.Functional magnetic resonance imaging studies indicated that non-specific effects play important roles in acupuncture analgesia.Lines of evidenee have pointed out that the regulation of neuro-endocrine-immune networks may be a common switch of acupuncture on different nerve system diseases.

关键词： acupuncture clinical trials mechanism anti-inflammation neuro-endocrine-immune network

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neuroendocrine-immune Regulating Mechanisms for the Anti-Inflammatory and Analgesic Actions of Acupuncture

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World Journal of Traditional Chinese Medicine 2020年第4期6卷 384-392页

作者： Zhi-Fang Xu Shou-Hai Hong Shen-Jun Wang Xue Zhao Yang-Yang Liu Sha-Sha Ding Yuan Xu Kuo Zhang Nan-Nan Yu Zhong-Xi Lu Fu-Ming Yang Yi-Nan Gong Qin-Qin He Kun Yu Yi-Ping Zhang Bao-Min Dou Lin Yao Ya-Wen Yan Tao Yang Yan-Fang Zhang Bao-Hu Liu Yong-Ming Guo Hsuah-Nee-Connie Wong Yi Guo Research Center of Experimental Acupuncture Science Tianjin University of Traditional Chinese Medicine National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion College of Traditional Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjinChina

Pain and inflammatory diseases are important clinical indications of acupuncture,which have been widely accepted in the international community.Previous studies have been focusing on rapid analgesia of acupuncture through the regulation of nervous system,but few studies on the inflammation regulatory mechanisms in which acupuncture inhibits the peripheral sensitization-induced pain.Based on studies concerning acupoint mechanisms of acupuncture actions and related researches on acupuncture regulating neuroendocrine and immune systems,we put forward the scientific hypothesis that acupuncture regulates neuroendocrine-immune(NEI)network and key response media therein,so as to achieve anti-inflammatory and analgesic effects in target organs.We have established a platform for acupuncture at ST36 to alleviate inflammatory pain in adjuvant induced arthritic rats.Based on the complex network analysis of multi-dimensional data from multi-time point and multi-site detection of NEI common signaling molecules,we have clarified the regulatory effects of acupuncture on NEI network and corresponding downstream immune network.Results indicated that monocytes/macrophages are the key targeting cells of acupuncture regulation,and acupuncture may display the anti-inflammatory and analgesic effects by regulating polarization of T cells in lymph nodes and polarization of M1/M2 macrophages in inflamed joints/paws.In addition,we have spotted a key molecule for acupuncture analgesia,CXCL1,as well as clarified the novel central analgesic mechanism of acupuncture mediated by CXCL1/CXCR2 desensitization.Thereby,we have provided novel evidence of the anti-inflammatory and analgesic actions of acupuncture through regulating NEI network and several key substances,highlighting a systemic research paradigm for investigating mechanisms of acupuncture actions.

关键词： Acupuncture anti-inflammation analgesia neuro-endocrine-immune network CXCL1

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