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Establishment of a Refined Brain Model for Evaluating Implantation Behavior of neural electrode and Research of its Simulated Behavior

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Journal of Shanghai Jiaotong university(Science) 2023年第4期28卷 401-410页

作者：贺雨欣张文光胥浩天徐倚帆许李悦 State Key Laboratory of Mechanical Systems and Vibration Shanghai Jiao Tong UniversityShanghai 200240China

The long-term reliability of the neural electrode is closely related to its implantation *** orderto realize the quantitative research of the implantation behavior in a low-cost and accurate way,a refined brainmodel containing meninges is ***,the expected simulation material was selected through measuringthe elastic modulus based on the method of atomic force microscope indentation *** a result,the 2%(mass fraction)agarose gel simulated the gray and white matter,the 7:1(volume ratio)polydimethylsiloxane(PDMS)sheet simulated the pia mater,and the polyvinyl chloride(PVC)film simulated the dura ***,based on designing a three-layer structure mold,the brain model was prepared by inverted pouring to realizea flat implantation ***,the simulation behavior of the brain model was investigated with the ratbrain as a *** mechanical behavior of implantation,the implantation force experienced two peaks bothin the brain model and the rat brain,maximum values of which were 10.17 mN and 7.69 mN *** implantation force in the brain model will increase the strength requirement for the electrode,but reducethe risk of buckling of that in practical *** humoral dissolution behavior,the dissolution rates ofthe polyethylene glycol(PEG)coating of the electrode in the brain model and rat brain were 7000μm3/s and5600μm3/s,*** faster dissolution rate in the brain model will cause the larger thickness of thecoating design but provide sufficient implantable time in practical *** establishment of the brainmodel and the research of its simulated behavior are beneficial to the size design of the electrode substrate andcoating,and research of the implantation mechanism,and further increase the functional life of the electrode.

关键词： neural electrode brain model implantation behavior

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Flexible and biocompatible nanopaper-based electrode arrays for neural activity recording

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Nano Research 2018年第10期11卷 5604-5614页

作者： Yichuan Guo Zhiqiang Fang Mingde Du Long Yang Leihou Shao Xiaorui Zhang Li Li Jidong Shi Jinsong Tao Jinfen Wang Hongbian Li Ying Fang CAS Key Laboratory for Biomedical Effects of Nanomatefials and Nanosafety CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology Beijing 100190 China University of Chinese Academy of Sciences Beijing 100049 China State Key Laboratory of Pulp and Paper Engineering South China University of Technology Guangzhou 510640 China Department of Neurobiology David Geffen School of Medicine University of California Los Angeles Los Angeles CA 90095 USA CAS Center for Excellence in Brain Science and Intelligence Technology 320 Yue Yang Road Shanghai 200031 China

Advances in neural electrode technologies can have a significant impact on both fundamental and applied neuroscience. Here, we report the development of flexible and biocompatible neural electrode arrays based on a nanopaper substrate. Nanopaper has important advantages with respect to polymers such as hydrophilicity and water wettability, which result in significantly enhanced biocompatibility, as confirmed by both in vitro viability assays and in vivo histological analysis. In addition, nanopaper exhibits high flexibility and good shape stability. Hence, nanopaper-based neural electrode arrays can conform to the convoluted cortical surface of a rat brain and allow stable multisite recording of epileptiform activity in vivo. Our results show that nanopaper-based electrode arrays represent promising candidates for the flexible and biocompatible recording of the neural activity.

关键词： nanopaper neural electrode biocompatibility flexible epilepsy

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Fabrication of iridium oxide neural electrodes at the wafer level

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Science China(Technological Sciences) 2016年第9期59卷 1399-1406页

作者： ZHANG He PEI WeiHua ZHAO ShanShan YANG XiaoWei LIU RuiCong LIU YuanYuan WU Xian GUO DongMei GUI Qiang GUO XuHong XING Xiao WANG YiJun CHEN HongDa State Key Laboratory on Integrated Optoelectronics Institute of Semiconductors Chinese Academy of Sciences Engineering Research Center for Semiconductor Integrated Technology Institute of Semiconductors Chinese Academy of Sciences

Electro-deposition, electrical activation, thermal oxidation, and reactive ion sputtering are the four primary methods to fabricate iridium oxide film. Among these methods, reactive ion sputtering is a commonly used method in standard micro-fabrication processes. In different sputtering conditions, the component, texture, and electrochemistry character of iridium oxide varies considerably. To fabricate the iridium oxide film compatible with the wafer-level processing of neural electrodes, the quality of iridium oxide film must be able to withstand the mechanical and chemical impact of post-processing, and simultaneously achieve good performance as a neural electrode. In this study, parameters of sputtering were researched and developed to achieve a balance between mechanical stability and good electrochemical characteristics of iridium oxide film on electrode. Iridium oxide fabricating process combined with fabrication flow of silicon electrodes, at wafer-level, is introduced to produce silicon based planar iridium oxide neural electrodes. Compared with bare gold electrodes, iridium oxide electrodes fabricated with this method exhibit particularly good electrochemical stability, low impedance of 386 kW at 1 kH z, high safe charge storage capacity of 3.2 m C/cm^2, and good impedance consistency of less than 25% fluctuation.

关键词： reactive ion sputtering iridium oxide wafer-level neural electrode

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Fabrication and modification of implantable optrode arrays for in vivo optogenetic applications

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Biophysics Reports 2018年第2期4卷 82-93页

作者： Lulu Wang Kang Huang Cheng Zhong Liping Wang Yi Lu Shenzhen Key Lab of Neuropsychiatric Modulation and Collaborative Innovation Center for Brain Science CAS Center for Excellence in Brain Science and Intelligence Technology The Brain Cognition and Brain Disease Institute Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences Shenzhen College of Advanced Technology University of Chinese Academy of Sciences

Recent advances in optogenetics have established a precisely timed and cell-specific methodology for understanding the functions of brain circuits and the mechanisms underlying neuropsychiatric disorders. However, the fabrication of optrodes, a key functional element in optogenetics, remains a great challenge. Here, we report reliable and efficient fabrication strategies for chronically implantable optrode arrays. To improve the performance of the fabricated optrode arrays, surfaces of the recording sites were modified using optimized electrochemical processes. We have also demonstrated the feasibility of using the fabricated optrode arrays to detect seizures in multiple brain regions and inhibit ictal propagation in vivo. Furthermore, the results of the histology study imply that the electrodeposition of composite conducting polymers notably alleviated the inflammatory response and improved neuronal survival at the implant/neural-tissue interface. In summary, we provide reliable and efficient strategies for the fabrication and modification of customized optrode arrays that can fulfill the requirements of in vivo optogenetic applications.

关键词： electrodeposition Electrophysiological recording neural electrode Optical stimulation Optogenetics Optrode

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