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Discrepancies between self-reported Checkf update medication in adherence and indirect measurement adherence among patients undergoing antiretroviral therapy:a systematic review

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Infectious Diseases of Poverty 2024年第4期13卷 1-13页

作者： Rujun Liao Zihuan Tang Na Zhang Lin Hu Zongqi Chang Jiayi Ren Xuefei Bai inhong Shi Sisi Fan Rong Pei Liang Du Tao Zhang Center of Infectious Diseases Research Center of Clinical Epidemiology and Evidence-Based MedicineInnovation Insititute for Integration of Medicine and EngineeringWest China HospitalSichuan UniversityChengdu 610041SichuanPeople's Republic of China Department of Epidemiology and Health Statistics West China School of Public Health and West China Fourth HospitalSichuan UniversityChengdu 610041SichuanPeople's Republic of China Sichuan Center for Disease Control and Prevention Chengdu 610041SichuanPeople's Republic of China School of Public Health Chengdu University of Traditional Chinese MedicineChengdu 611130SichuanPeople's Republic of China

Background Given the critical importance of medication adherence in HIV/AIDS treatment,this study aims to com-pare medication adherence measured by self-report(SR)and indirect measurement among antiretroviral therapy(ART)patients,exploring the differences of adherence results measured by different *** We systematically searched PubMed,Embase,and the Cochrane Library to identify all relevant literature published up to November 22,2023,without language restrictions,reporting adherence to ART measured by both SR and indirect measurement methods,while also analyzing individual and group adherence *** between SR and indirect measurement results were assessed using the Mann-Whitney U test or Wilcoxon signed-rank test,with correlations evaluated using the Pearson correlation *** one-to-one comparisons,meta-epidemiological one-step analysis was conducted,and network meta-analysis techniques were applied to compare results obtained through specific adherence assessment tools reported in the identified *** The analysis encompassed 65 original studies involving 13,667 HIV/AIDS patients,leading to 112 one-to-one comparisons between SR and indirect measurement *** significant differences were observed between SR and indirect measurement tools regarding both individual and group adherence(Panalysis,SR-measured adherence was determined to be 3.94%(95%Cl:-4.48-13.44%)higher for individual adherence and 16.14%(95%Cl:0.81-18.84%)higher for group adherence compared to indirectly measured *** analysis indicated that factors such as the year of reporting and geographic region appeared to influence the discrepancies between SR and indirect ***,network meta-analysis revealed that for both individual and group adherence,the results obt

关键词： HIV AIDS Antiretroviral therapy Medication adherence Self-report Meta-epidemiological one-step analysis networkmeta-analysis

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针灸辅助改善冻融胚胎移植疗效的网状meta分析

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World Journal of Acupuncture-Moxibustion 2024年第2期34卷 103-116页

作者：罗敏辉谭艳左耀辰石文英王鑫章薇湖南中医药大学长沙410208 湖南中医药大学第一附属医院长沙410007

Objective:To evaluate the clinical effect of acupuncture-moxibustion as the adjuvant therapy on frozenthawed embryo transfer(FET)using network ***:In PubMed,Embase,Cochrane Library,Chinese National Knowledge Infrastructure(CNKI),Wanfang database(WanFang),VIP database and Chinese Biomedical Literature Database(SinoMed),the randomized controlled trials(RCTs)of the adjuvant therapy of acupuncture-moxibustion for FET were retrieved,from database inception to April 1,*** risk of bias assessment tool was used to screen and evaluate the quality of the included studies,and RevMan 5.3,GeMTC0.14.3 and Stata16.0 software were adopted to complete the network ***:Twenty-nine RCTs comprising 2880 patients were finally included,involving 17 interventions and 4 outcome *** results of network meta-analysis showed that the top three therapies under each outcome based on the magnitude of SUCRA values were:(1)Clinical pregnancy rate(CPR,%):"transcutaneous electrical acupoint stimulation+herbal medicine"(76.4),"moxibustion+herbal medicine"(74.7),"acupuncture+moxibustion"(73.3);(2)Biochemical pregnancy rate(BPR):"moxibustion+herbal medicine"(89.3),"acupuncture+moxibustion"(82.1),"acupuncture+herbal medicine"(78.7);(3)Endometrial thickness:"acupoint injection+Western medicine"(87.2),auricular therapy(76.8),"acupuncture+herbal medicine"(73.5);(4)Type A endometrial morphology rate:"acupoint injection+Western medicine"(78.3),"moxibustion+herbal medicine"(58.0)and"acupuncture+moxibustion"(52.6).Conclusion:The combined treatment of acupuncture-moxibustion was superior to single therapy for FET *** combined therapy of transcutaneous electrical acupoint stimulation and herbal medicine had the best effect for improving CPR,"moxibustion+herbal medicine"obtained the best average comprehensive effect,and"acupoint injection+Western medicine"was conductive to ameliorate the endome trial thickness and *** to the limitations of e

关键词： Acupuncture Moxibustion Frozen-thawed embryotransfer Pregnancy rate Endometriumthickness Endometrial morphology networkmeta-analysis

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Efficacy and safety of first-line treatment for metastatic triple-negative breast cancer:A network meta-analysis

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Cancer Pathogenesis and Therapy 2024年第2期2卷 81-90页

作者： Mingqiang Shi Zhoujuan Li Guoshuang Shen Tianzhuo Wang Jinming Li Miaozhou Wang Zhen Liu Fuxing Zhao Dengfeng Ren Jiuda Zhao Breast Disease Diagnosis and Treatment Center of Affiliated Hospital of Qinghai University&Affiliated Cancer Hospital of Qinghai UniversityXiningQinghai 810000China

Background:Metastatic triple-negative breast cancer(mTNBC)is an aggressive histological subtype with poor *** first-line treatments are currently available for *** study conducted a network meta-analysis to compare these first-line regimens and to determine the regimen with the best ***:A systematic search of PubMed,EMBASE,the Cochrane Central Register of Controlled Bases,and mi-nutes of major conferences was ***-free survival(PFS),overall survival(OS),and objective response rate(ORR)were analyzed via network meta-analysis using the R software(R Core Team,Vienna,Austria).The efficacy of the treatment regimens was compared using hazard ratios and 95%confidence ***:A total of 29 randomized controlled trials involving 4607 patients were *** ranking was based on the surface under the cumulative ranking *** meta-analysis results showed that cisplatin combined with nab-paclitaxel or paclitaxel was superior to docetaxel plus capecitabine in terms of PFS and *** programmed death-ligand 1(PD-L1)and breast cancer susceptibility gene(BRCA)mutation-positive tumors,atezolizumab/pembrolizumab combined with nab-paclitaxel and talazoparib was superior to docetaxel plus *** significant difference was observed among the treatments in ***,diarrhea,and fatigue were common serious adverse ***:Cisplatin combined with nab-paclitaxel or paclitaxel is the preferred first-line treatment for *** PD-L1 and BRCA mutation-positive tumors,atezolizumab/pembrolizumab combined with nab-paclitaxel and talazoparib is an effective treatment option,Neutropenia,diarrhea,and fatigue are frequently occurring serious adverseevents.

关键词： Metastatictriple-negativebreast cancer First-line treatment Chemotherapy Immune-checkpoint inhibitors Poly(ADP-Ribose)polymerase inhibitors AKT inhibitor networkmeta-analysis

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