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Construction of a predictive model for gastric cancer neuroaggression and clinical validation analysis: A single-center retrospective study

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World Journal of Gastrointestinal Surgery 2024年第8期16卷 2602-2611页

作者： Yu-Yin Lan Jing Han Yan-Yan Liu Lei Lan Department of Stomatology Shanghai Municipal Hospital of Traditional Chinese MedicineShanghai University of Traditional Chinese MedicineShanghai 200071China Department of Biobank Zhejiang Cancer HospitalHangzhou 310005Zhejiang ProvinceChina Department of General Surgery Peking University First HospitalBeijing 100034China Department of Oncology Zhejiang HospitalHangzhou 310013Zhejiang ProvinceChina

BACKGROUND This study investigated the construction and clinical validation of a predictive model for neuroaggression in patients with gastric *** cancer is one of the most common malignant tumors in the world,and neuroinvasion is the key factor affecting the prognosis of ***,there is a lack of systematic analysis on the construction and clinical application of its prediction *** study adopted a single-center retrospective study method,collected a large amo-unt of clinical data,and applied statistics and machine learning technology to build and verify an effective prediction model for neuroaggression,with a view to providing scientific basis for clinical treatment decisions and improving the tr-eatment effect and survival rate of patients with gastric *** To investigate the value of a model based on clinical data,spectral computed to-mography(CT)parameters and image omics characteristics for the preoperative prediction of nerve invasion in patients with gastric *** A retrospective analysis was performed on 80 gastric cancer patients who under-went preoperative energy spectrum CT at our hospital between January 2022 and August 2023,these patients were divided into a positive group and a negative group according to their pathological *** data were collected,the energy spectrum parameters of primary gastric cancer lesions were measured,and single factor analysis was performed.A total of 214 image omics features were extracted from two-phase mixed energy images,and the features were screened by single factor analysis and a support vector *** variables with statist-ically significant differences were included in logistic regression analysis to construct a prediction model,and the performance of the model was evaluated using the subject working characteristic *** were statistically significant differences in sex,carbohydrate antigen 199 expression,tumor thickness,Lauren classification

关键词： Gastric neoplasms nerve invasion Tomography X-ray computer Imaging omics Diagnostic differentiation

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Energy spectrum computed tomography multi-parameter imaging in preoperative assessment of vascular and neuroinvasive status in gastric cancer

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World Journal of Gastrointestinal Surgery 2024年第8期16卷 2511-2520页

作者： Jing Wang Jian-Cheng Liang Fa-Te Lin Jun Ma Department of Radiology Pingluo County People's HospitalShizuishan 753400Ningxia Hui Autonomous RegionChina Department of Gastrointestinal Surgery Jiangsu Provincial People's HospitalNanjing 210029Jiangsu ProvinceChina

BACKGROUND Vascular and nerve infiltration are important indicators for the progression and prognosis of gastric cancer(GC),but traditional imaging methods have some limitations in preoperative *** recent years,energy spectrum computed tomography(CT)multiparameter imaging technology has been gradually applied in clinical practice because of its advantages in tissue contrast and lesion detail *** To explore and analyze the value of multiparameter energy spectrum CT imaging in the preoperative assessment of vascular invasion(LVI)and nerve invasion(PNI)in GC *** Data from 62 patients with GC confirmed by pathology and accompanied by energy spectrum CT scanning at our hospital between September 2022 and September 2023,including 46 males and 16 females aged 36-71(57.5±9.1)years,were retrospectively *** patients were divided into a positive group(42 patients)and a negative group(20 patients)according to the presence of LVI/*** CT values(CT40 keV,CT70 keV),iodine concentration(IC),and normalized IC(NIC)of lesions in the upper energy spectrum CT images of the arterial phase,venous phase,and delayed phase 40 and 70 keV were measured,and the slopes of the energy spectrum curves[K(40-70)]from 40 to 70 keV were *** Core Tip:To investigate the application value of multiparameter energy spectrum computed tomography(CT)imaging in the preoperative assessment of vascular and nerve infiltration in patients with gastric cancer(GC).The imaging data of GC patients were retrospectively analyzed to evaluate the accuracy and sensitivity of CT for identifying and quantifying vascular and nerve infiltration and for comparison with postoperative pathological *** purpose of this study was to verify the clinical feasibility and potential advantages of multiparameter energy spectrum CT imaging in guiding preoperative diagnosis and treatment decision-making and to provide a new imaging basis for improving the diagnostic accuracy

关键词： Tomography X-ray computer Energy spectrum computed tomography Gastric cancer Vascular invasion nerve invasion Cross-sectional study

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Analysis of risk factors affecting the prognosis of pancreatic neuroendocrine tumors

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Chinese Medical Journal 2014年第16期127卷 2924-2928页

作者： Tao Ming Yuan Chunhui Xiu Dianrong Shi Xueying Tao Liyuan Ma Zhaolai Jiang Bin Zhang Zhipeng Zhang Lingfu Wang Hangyan Department of General Surgery Peking University Third HospitalBeijing 100191 China Department of Pathology Peking University Health Science CenterBeijing 100191 China Peking University Third Hospital Research Center of Clinical Epidemiology Beijing 100191 China

Background Pancreatic neuroendocrine tumors （pNETs） are a type of tumors with the characteristics of easy metastasis and *** date,the risk factors affecting the prognosis are still in the *** this study,several risk factors will be discussed combined with our cases and *** Thirty-three patients diagnosed as pNETs were enrolled and the clinical features,blood tests,pathological features,surgical treatment,and follow-up data of these patients were collected and *** In this study,operation time of G3 cases was longer than G1/G2 cases （P=0.017）.The elevated level of tumor markers such as AFP,CEA,Ca125,and Ca19-9 may predict easier metastasis,earlier recurrence,and poor prognosis （P=0.007）.The presence of cancer embolus and nerve invasion increases along with the TNM stage （P=0.037 and P=0.040）,and the incidence of positive surgical margin increased （P=0.007）.When the presence of nerve invasion occurs,the chance of cancer embolus and lymph node metastasis also increases （P=0.016 and P=0.026）.Conclusions pNETs were tumors with the features of easy recurrence and metastasis and many risk factors could affect its prognosis such as the elevated levels of tumor markers and the presence of nerve invasion,except some recognized risk *** one or more of these factors existed,postoperative treatments may be needed to improve prognosis.

关键词： tumor marker risk factors nerve invasion prognosis pancreatic neuroendocrine tumors

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