检索结果-南通市图书馆

Pathological and Etiological Aspects of nephrotic syndrome at the Niamey General Reference Hospital

Open Journal of Nephrology 2024年第3期14卷 340-349页

作者： Djibrilla Gani Salamatou Amadou Niaouro Oumarou Ali Diallo Nephrology-Dialysis Department Niamey General Reference Hospital Niamey Niger Environmental Health and Climate Epidemiology Unit (UESEC)-CERMES Niamey Niger

Introduction: Studies have been conducted on nephrotic syndrome in Niger. The study aimed to determine the histological and etiological aspects of nephrotic syndrome. Patients and Method: This was a retrospective study from February 1st, 2018 to January 31st, 2024. All patients with nephrotic syndrome who underwent renal biopsy were included. Samples were analyzed at the anatomy-cytology pathology laboratory of the Faculty of Medicine in Dakar (Senegal). The variables studied included clinical, biological, histological and etiological characteristics. Data were analyzed using Excel 2013 and Epi-info 7.2.0 software. Results: The study included 119 patients with nephrotic syndrome. Prevalence of nephrotic syndrome was 11.24%. The male-to-female ratio was 2.25:1. The mean age at diagnosis was between 34.5 ± 18.84 years. Edema was the reason for admission in 40.34% of cases. The nephrotic syndrome was impure in 63.86% of cases. Nine histological lesions were identified. Focal and segmental glomerulosclerosis (40.09%), minimal change disease (23.53%), membranous nephropathy (13.45%), diabetic nephropathy (10.92%), membranous proliferative glomerulonephritis (3.36%), acute glomerulonephritis (3.36%), glomerular thrombotic microangiopathy (2.52%), non-IgA mesengial proliferative glomerulonephritis (1.68%) and amyloidosis (0.84%). nephrotic syndrome was primary in 57.98% of cases. Secondary etiologies were dominated by diabetes (11.76%), followed by hepatitis B virus (9.24%), lupus, lymphoma, malaria, syphilis, cryoglobulinemia, sickle cell disease and HIV. Conclusion: Future studies should investigate the causes of glomerulopathy secondary to chronic tubulointerstitial lesions.

关键词： nephrotic syndrome Anatomopathology Niamey General Reference Hospital

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

HDR syndrome presented with nephrotic syndrome in a Chinese boy: A case report

引用

World Journal of Clinical Cases 2024年第27期12卷 6111-6116页

作者： Li-Juan Ma Wu Yang Hong-Wen Zhang Department of Pediatrics Peking University First Hospital Ningxia Women and Children’s HospitalYinchuan 750001Ningxia Hui Autonomous RegionChina Department of Pediatric Peking University First HospitalBeijing 100034China

BACKGROUND HDR syndrome is a rare genetic disease caused by variants in the GATA3 gene and is phenotypically defined by the triad of hypoparathyroidism(H),deafness(D),and renal disease(R).Renal disorders of HDR are mainly developmental ab-normalities,although renal functional abnormalities can also be ***-phrotic syndrome or nephrotic-level proteinuria is rare in HDR ***,we report a Chinese infant with HDR syndrome who presented with early-onset nephrotic *** suggest that variants in the GATA3 gene might be asso-ciated with nephrotic syndrome.(***235 Leu),in exon 3 of the GATA3 *** We report an infant with HDR syndrome who presented with early-onset nephrotic syndrome in *** suggest that variants in the GATA3 gene might be associated with infant-onset nephrotic syndrome.

关键词： HDR syndrome Sensorineural deafness nephrotic syndrome China Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Evaluation of thyroid profile among children aged 1-15 years with nephrotic syndrome:An observation study

引用

World Journal of Clinical Pediatrics 2024年第3期13卷 34-39页

作者： Priyanka Kumari Amit Agrawal Jyotsna Shrivastava Department of Pediatrics Gandhi Medical CollegeBhopal 462030India Department of Pediatrics Gandhi Medical CollegeHamidia Hospital CampusBhopal 462022India

BACKGROUND The interaction between the kidney and the thyroid is important for normal function of both *** nephrotic syndrome,proteinuria leads to loss of several proteins,which in turn causes *** To assess the thyroid function in children with nephrotic *** This cross-sectional study was conducted in a tertiary center,Bhopal,from February 2020 to January *** children aged 1-15 years admitted with nephrotic syndrome(first-time diagnosed and all relapse cases)were included in the study.A thyroid profile was sent along with routine investigations,and thyroid hormone status was assessed in nephrotic syndrome *** Of the 70 patients,39(55.7%)showed abnormal thyroid profiles;19(27.1%)had overt hypothyroidism,and 20(28.6%)had subclinical *** hypothyroidism was seen in 16.1%of newly diagnosed cases,40%of second relapses,and 2.7%of frequently relapsed cases(Pnephrotic syndrome,and overt hypothyroidism was more common in frequent relapse ***,thyroid screening should be a part of the management of nephrotic syndrome so that hypothyroidism can be detected and managed at an early stage.

关键词： nephrotic syndrome Hypothyroidism Proteinuria Children Steroid-sensitive nephrotic syndrome Steroidresistant nephrotic syndrome

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

nephrotic syndrome in syngeneic hematopoietic stem cell transplantation recipients: A case report

引用

World Journal of Clinical Cases 2021年第3期9卷 614-622页

作者： Ming-Chuan Bai Jing-Jing Wu Kou-Rong Miao Jing-Feng Zhu Hui-Juan Mao Department of Nephrology The First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029Jiangsu ProvinceChina Department of Hematology The First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029Jiangsu ProvinceChina

BACKGROUND Hematopoietic stem cell transplantation(HSCT)is widely used in the treatment of hematological ***,complications after transplantation,such as acute and chronic graft-vs-host disease(GVHD),still seriously affect the quality of life and even threaten the lives of *** is evidence that glomerular diseases can manifest as ***,GVHD should not occur as a result of syngeneic *** SUMMARY A 20-year-old male diagnosed with T lymphoblastic lymphoma(stage IIIA,aaIPI 1)in September 2013 was treated with six cycles of hyper-CVAD and achieved complete *** underwent syngeneic HSCT in June 2014,and had no kidney disease history before the ***,nephrotic syndrome occurred 24 mo later in the patient after syngeneic *** biopsy was performed,which led to a diagnosis of atypical membranous *** treatment with glucocorticoids combined with cyclophosphamide and cyclosporine,the nephrotic syndrome was completely *** We report a case of delayed nephrotic syndrome after syngeneic *** autoimmune glomerular disease may be the underlying *** treatment with immunosuppressive agents,the nephrotic syndrome was completely relieved but further long-term follow-up is still needed.

关键词： Syngeneic hematopoietic stem cell transplantation nephrotic syndrome Graft vs host disease Cyclosporine Autoimmune glomerular disease Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Sinkihwan-gamibang ameliorates puromycin amino nucleoside-induced nephrotic syndrome

引用

Chinese Journal of Natural Medicines 2022年第3期20卷 177-184页

作者： Lee Hyeon Kyoung Jang Youn Jae Na Se Won Kim Hye Yoom Han Bywig Hyuk Lee Yun Jung Lee Ho Sub Yoon Jung Joo Kang Dae Gill Hanbang Cardio-Renal syndrome Research Center Wonkwang UniversityJeollabukdo 54538Republic of Korea College of Oriental Medicine and Professional Graduate School of Oriental Medicine Wonkwang UniversityJeollabukdo 54538Republic of Korea

nephrotic syndrome(NS)is a kidney disease characterized by hypertriglyceridemia,massive proteinuria,hypo-albuminemia and peripheral ***-gamibang(SKHGMB)was recorded in a traditional Chinese medical book named“Bangyakhappyeon(方藥合編)”and its three prescriptions Sinkihwan,Geumgwe-sinkihwan,and Jesaeng-sinkihwan belong to *** study confirmed the effect of SKHGMB on renal dysfunction in an NS model induced by puromycin aminonucleoside(PAN).The experimental NS model was induced in male Sprague Dawley(SD)rats through injection of PAN(50 mg·kg^(-1))via the femoral *** not only reduced the size of the kidneys increased due to PAN-induced NS,but also decreased proteinuria and *** addition,SKHGMB significantly ameliorated creatinine clearance,creatinine,and blood urea *** relieved glomeruli dilation and tubules fibrosis in the glomeruli of the NS *** inhibited the protein and mRNA levels of the NLRP3 inflammasome including NLRP3,ASC,and pro-caspase-1 in NS *** reduced the protein and mRNA levels of fibrosis regulators in NS *** results indicated that SKHGMB exerts protective effects against renal dysfunction by inhibiting of renal inflammation and fibrosis in NS rats.

关键词： Sinkihwan-gamibang Puromycin aminonucleoside nephrotic syndrome Renal dysfunction NLRP3 inflammasome Fibrosis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Ephedra Herb extract ameliorates adriamycin-induced nephrotic syndrome in rats via the CAMKK2/AMPK/mTOR signaling pathway

引用

Chinese Journal of Natural Medicines 2023年第5期21卷 371-382页

作者： ZHANG Yuhan ZENG Mengnan LI Benke ZHANG Beibei CAO Bing WU Yuanyuan YE Shan XU Ruiqi ZHENG Xiaoke FENG Weisheng College of Pharmacy Henan University of Chinese MedicineZhengzhou 450000China The Engineering and Technology Center for Chinese Medicine Development of Henan province Zhengzhou 450000China Co-construction Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan&Education Ministry of P.R. Zhengzhou 450000China

This study aimed to investigate the effect and mechanisms of Ephedra Herb(EH)extract on adriamycin-induced nephrotic syndrome(NS),providing an experimental basis for the clinical treatment of *** and eosin staining,creatinine,urea nitrogen,and kidn injury molecule-1 were used to evaluate the activities of EH extract on renal *** levels of inflammatory factors and oxidative stress were detected by *** levels of reactive oxygen species,immune cells,and apoptosis were measured by flow cytometry.A network pharmacological approach was used to predict the potential targets and mechanisms of EH extract in the treatment of *** protein levels of apoptosis-related proteins and CAMKK2,p-CAMKK2,AMPK,p-AMPK,mTOR and p-mTOR in the kidneys were detected by Western *** effective material basis of EH extract was screened by MTT *** AMPK pathway inhibitor(compound C,CC)was added to investigate the effect of the potent material basis on adriamycin-induced cell *** extract significantly improved renal injury and relieve inflammation,oxidative stress,and apoptosis in *** pharmacology and Western blot results showed that the effect of EH extract on NS may be associated with the CAMKK2/AMPK/mTOR signaling ***,methylephedrine significantly ameliorated adriamycin-induced NRK-52e cell *** also significantly improved the phosphorylation of AMPK and mTOR,which were blocked by *** sum,EH extract may ameliorate renal injury via the CAMKK2/AMPK/mTOR signaling ***,methylephedrine may be one of the material bases of EH extract.

关键词： Ephedra Herb Methylephedrine Adriamycin nephrotic syndrome CAMKK2/AMPK/mTOR pathway

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Genetic basis of adult-onset nephrotic syndrome and focal segmental glomerulosclerosis

引用

Frontiers of Medicine 2017年第3期11卷 333-339页

作者： Jian Liu Weiming Wang Institute of Nephrology Shanghai Jiao Tong University School of Medicine Shanghai 200025 China Department of Nephrology Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai 200025 China

nephrotic syndrome （NS） is one of the most common glomerular diseases with signs of nephrosis, heavy proteinuria, hypoalbuminemia, and edema. Dysfunction of glomerular filtration barrier causes protein loss through the kidneys. Focal segmental glomerulosclerosis （FSGS） accounts for nearly 20% of NS among children and adults. Adult-onset FSGS/NS is often associated with low response to steroid treatment and immunosup- pressive medication and poor renal survival. Several genes involved in NS and FSGS have been identified by linkage analysis and next-generation sequencing. Most of these genes encode proteins and are highly expressed in glomerular podocytes, which play crucial roles in slit-diaphragm signaling, regulation of actin cytoskeleton dynamics and maintenance of podocyte integrity, and cell-matrix interactions. In this review, we focus on the recently identified genes in the adult-onset NS and FSGS and discuss clinical significance of screening of these genes.

关键词： nephrotic syndrome focal segmental glomerulosclerosis genetic

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Efficacy and safety of Huaiqihuang granule as adjuvant treatment for primary nephrotic syndrome in children: a meta-analysis and systematic review

引用

World Journal of Pediatrics 2021年第3期17卷 242-252页

作者： Jiao Lin Li-Min Huang Jing-Jing Wang Jian-Hua Mao Department of Nephrology National Clinical Research Center For Child HealthChildren’s HospitalZhejiang University School of MedicineHangzhou 310003China

Background Huaiqihuang(HQH)granule is a traditional Chinese herbal complex that has been used as an adjuvant treatment in clinics for the primary nephrotic syndrome(PNS)for many ***,the effectiveness and safety of HQH have not been systematically *** review aimed to evaluate the effectiveness and safety of HQH in paediatric patients with *** The following databases were searched from inception to Mar 2019:MEDLINE,Cochrane Library,EMBASE,CNKI,Wanfang Database,the Chinese Scientific Journal Database and the Chinese biomedical literature service *** the randomized controlled trials(RCTs)eligible for inclusion were *** primary outcomes were relapse,infection,remission and adverse *** secondary outcomes included serum immunoglobulin levels(IgA,IgG or IgM),T-lymphocyte subtype(CD3+,CD4+,CD8+,CD4+/CD8+),IL-10,TNF-α,TNF-γ,total cholesterol and time of proteinuria turning *** Fourteen RCTs(885 patients)were *** with HQH reduced the chance of relapse[relative risk(RR):0.47;95%CI:0.34,0.66;P<0.001]and infections(RR:0.47;95%Cl:0.35,0.62;P<0.001).No significant difference was found in adverse *** also increased the serum levels of IgA[weighted mean difference(WMD):0.40;95%Cl:0.20,0.60;P<0.001]and IgG(WMD:1.58;95%Cl:1.38-1.78;P<0.001),as well as CD4+[standard mean difference(SMD):0.90;95%Cl:0.12-1.68;P=0.02],CD3+(WMD:4.04;95% CI:3.27-4.82;P<0.001),and the CD4^(+)/CD8^(+)ratio(WMD:0.31;95% CI:0.21-0.41;P<0.001),but decreased the level of CD8+cells(WMD:-3.39;95% CI:-5.73-1.05;P=0.004).No statistically significant difference was found in IgM(WMD:0.05;95% CI:-0.13,0.24;P=0.57).Conclusions HQH could reduce the rate of relapse and the frequency of infection in children with *** apparent adverse effects were ***,the beneficial influence of HQH may act through *** multi-center,large-sample,high-quality studies are needed to confirm the effectiveness and safety of

关键词： Children Huaiqihuang nephrotic syndrome Meta-analysis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effect of Poria cocos Hydroethanolic Extract on Treating Adriamycin-Induced Rat Model of nephrotic syndrome

引用

Chinese Journal of Integrative Medicine 2017年第12期23卷 916-922页

作者： ZAN Jun-feng SHEN Chan-juan ZHANG Li-ping LIU Yan-wen Provincial and the Ministry of Education Key Laboratory of Resource Science and Chinese Herbal Compound in Chinese Medicine Hubei University of Chinese MedicineWuhan(430065)China Pharmacy Faculty Hubei University of Chinese MedicineWuhan(430065)China

Objective: To evaluate the effect of Poria cocos(Schw.) Wolf hydroethanolic extract(PHE) against nephrotic syndrome(NS) in rats and to identify the potential active components from PHE. Methods: The high content compounds were isolated and purified by using column chromatography followed by preparative highperformance liquid chromatography(p-HPLC). Forty male Wistar rats with adriamycin(ADR)-induced NS were randomly divided into 5 groups, 8 in each group: model control group, positive control group(with prednisone treatment), PHE low-dose group, PHE middle-dose group and PHE high-dose group. Another 8 rats were recruited as vehicle control group. All rats received the intragastric administration of corresponding drugs or saline for 30 days. During the experimental period, rats’ behavior and appearance were observed and recorded daily, and their body weights were recorded weekly. After treatment, 24-h urine samples were collected to evaluate the urine protein and urine creatinine(Ucr); then the rats were sacrificed to collect carotid blood and to determine the levels of serum total protein(TP), albumin(Alb), globulin(Glo), total cholesterol(TC) and cytokine interlukin-4(IL-4). Results: Six acidic components were isolated and identified from the PHE section: pachymic acid, 15α-hydroxydehydrotumulosic acid, trametenolic acid, dehydropachymic acid, 3β-hydroxy-lanosta-7,9(11), 24-trien-21-oic-acid and dehydroeburicoic acid. Compared with the model control group, the urine protein content were significantly decreased in the PHE treatment groups and positive control group(P<0.05), especially PHE middle-dose group(P<0.01). The Ucr values and serum levels of TP, Glo, TC and IL-4 in PHE low-and middle-dose groups were also presented obvious recover tendency as compared with the model control group(P<0.05 or P<0.01). However, positive control group and all PHE groups indicated no significant therapeutic effect on raising Alb value, although PHE low-and middle-dose treatment gr

关键词： Poria cocos hydroethanolic extract nephrotic syndrome Chinese medicine

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Pulmonary embolism associated with nephrotic syndrome in children: a preliminary report of 8 cases

引用

Chinese Medical Journal 2000年第3期113卷 59-61页

作者：黄建萍杨霁云丁洁 Department of Pediatric First Hospital Affiliated Beijing Medical University Beijing 100034 China

Objective To investigate the incidence, clinical features of pulmonary embolism (PE) secondary to nephrotic syndrome(NS) in Chinese *** Pulmonary perfusion imaging (PPI) and chest radiography was performed on 20 NS patients with elevated plasma D dimer. The patients with PE were given anticoagulative therapy with heparin and *** Among 20 NS patients, eight cases, aged from 5 to 12 years, 6 boys and 2 girls, were found to have PE. Of them 5 were primary NS and 3 were secondary NS. PPI showed an involvement of 1 pulmonary segment in 3 cases, of 2 pulmonary segments in 2, of 3 pulmonary segments in 2 ,and of 6 pulmonary segments in 1. Most patients did not present clinical signs and symptoms. Two weeks after the administration of intravenous heparin for anticoagulative therapy, 6 out of 8 cases showed a recovery or an improvement. Conclusion The results of this study suggest that PE be not a rare complication in NS children. Most patients had no obvious clinical manifestation and their prognose was favorable if diagnosed and treated in time.

关键词： nephrotic syndrome pulmonary embolism heparin

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：