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Metastatic clear cell renal cell carcinoma in isolated retroperitoneal lymph node without evidence of primary tumor in kidneys: A case report

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World Journal of Clinical Oncology 2020年第2期11卷 103-109页

作者： Lisa BE Shields Arash Rezazadeh Kalebasty Norton Neuroscience Institute Norton HealthcareLouisvilleKY 40202United States Norton Cancer Institute Norton HealthcareLouisvilleKY 40202United States

BACKGROUND Retroperitoneal lymph node dissection(RPLND)plays a diagnostic,therapeutic,and prognostic role in myriad urologic malignancies,including testicular carcinoma,renal cell carcinoma(RCC),and upper urinary tract urothelial *** represents 2%of all cancers with approximately 25%of patients presenting with advanced *** cell RCC(CCRCC)is the most common RCC,accounting for 75%-80%of all *** SUMMARY A 71-year-old man presented with a history of benign prostatic *** was asymptomatic without any hematuria,pain,or other urinary symptoms.A computed tomography(CT)scan of the abdomen and pelvis showed a 1.8 cm left retroperitoneal lymph *** was no evidence of renal pathology.A core biopsy was performed of the left para-aortic lymph *** the primary tumor site was unknown,the morphological and immunohistochemical features were most consistent with CCRCC.A RPLND was performed which revealed a single mass 5.5 cm in greatest dimension with extensive *** retroperitoneal lymph node was most compatible with CCRCC.A nephrectomy was not conducted as a renal mass had not been detected on any prior imaging *** patient did not receive any type of adjuvant *** patient underwent surveillance with serial CT scans with contrast of the chest,abdomen,and pelvis for the next 5 years,all of which demonstrated no recurrent or metastatic disease and no evidence of retroperitoneal *** Our unique case emphasizes the therapeutic role of metastasectomy in metastatic CCRCC even in the absence of primary tumor in the kidneys.

关键词： Oncology Renal cell carcinoma Clear cell carcinoma Lymph node dissection Retroperitoneal Metastasis nephrectomy without primary site Case report

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