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Genomic profile concordance between pancreatic cyst fluid and neoplastic tissue

World Journal of Gastroenterology 2019年第36期25卷 5530-5542页

作者： Arthur Laquière Arnaud Lagarde Bertrand Napoléon Raphael Bourdariat Alexandre Atkinson Gianfranco Donatelli Bernard Pol Laurence Lecomte Laurence Curel Romina Urena-Campos Thierry Helbert Vincent Valantin Francois Mithieux Jean Pascal Buono Philippe Grandval Sylviane Olschwang Department of Gastroenterology Saint Joseph Hospital Marseille 13008 France AP-HM Timone Hospital Marseille 13005 France RGDS Clairval Hospital Marseille 13009 France Aix-Marseille Univ INSERM MMG Marseille 13385 France AP-HM Conception Hospital Marseille 13385 France RGDS Jean Mermoz Hospital Lyon 69008 France RGDS Les Peupliers Hospital Paris 75013 France Department of Digestive Surgery Saint-Joseph Hospital Marseille 13008 France Department of Clinical Research Saint Joseph Hospital Marseille 13008 France European Hospital Marseille 13003 France Pathological Anatomy and Cytology MEDIPATH Eguilles 13510 France

BACKGROUND DNA mutational analysis of pancreatic cystic fluid (CF) is a useful adjunct to the evaluation of pancreatic cysts. KRAS/GNAS or RAF/PTPRD/CTNNB1/RNF43 mutations are highly specific to precancerous or advanced neoplasia. Several studies recently demonstrated the ability of next-generation sequencing (NGS)analysis to detect DNA mutations in pancreatic CF, but few studies have performed a systematic comparative analysis between pancreatic CF and neoplastic surgical tissue (NT). The value of CF-NGS analysis indicators for determining surgical resection necessitates evaluation. AIM To confirm whether CF genomic profiles are a reliable malignancy predictor by comparing NGS mutational analyses of CF and NT. METHODS Patients requiring surgery for high-risk pancreatic cysts were included in a multicenter prospective pilot study. DNA from CF (collected by endoscopic ultrasound-guided fine needle aspiration (known as EUS-FNA)) and NT (collected by surgery) were analyzed by NGS. The primary objective was to compare the mutation profiles of paired DNA samples. The secondary objective was to correlate the presence of specific mutations (KRAS/GNAS, RAF/ PTPRD/CTNNB1/RNF43/POLD1/TP53) with a final cancer diagnosis. Sensitivity and specificity were also evaluated. RESULTS Between December 2016 and October 2017, 20 patients were included in this pilot study. Surgery was delayed for 3 patients. Concordant CF-NT genotypes were found in 15/17 paired DNA, with a higher proportion of mutated alleles in CF than in NT. NGS was possible for all pancreatic CF collected by EUS-FNA. In 2 cases, the presence of a KRAS/GNAS mutation was discordant between CF and NT. No mutations were found in 3 patients with NT or pancreatic cysts with high-grade dysplasia. The sensitivity and specificity of KRAS/GNAS mutations in CF to predict an appropriate indication for surgical resection were 0.78 and 0.62, respectively. The sensitivity and specificity of RAF/PTPRD/CTNNB1 /RNF43/POLD1/TP53 mutatio

关键词： Pancreatic cancer Pancreatic cystic neoplasms Pancreatic adenocarcinoma Malignancy prediction neoplastic surgical tissue Pancreatic cystic fluid Molecular analysis Next-generation sequencing DNA mutations

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Higher risk of neoplastic progression of Barrett’s esophagus in patients with systemic sclerosis

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Gastroenterology Report 2021年第6期9卷 595-596页

作者： Mythri Anilkumar Motasem Alkhayyat Udhayvir S.Grewal Madhusudhan R.Sanaka Prashanthi N.Thota Center of Excellence for Barrett’s Esophagus Digestive Disease InstituteCleveland ClinicClevelandOHUSA Department of Internal Medicine Louisiana State University Health ShreveportShreveportLAUSA

Systemic sclerosis(SSc)is a multisystem connective-tissue disorder of unknown etiology affecting various internal organs and *** involvement is present in≤70%–90%of the patients and is manifested by severe gastroesophageal-reflux disease and *** Barrett’s esophagus(BE)has been reported in patients with SSc[1,2],the risk of neoplastic progression has not been reported before in the ***,we aimed to study the prevalence of BE in SSc and incidence of neoplastic progression.

关键词： Barrett neoplastic patients

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neoplastic macrovascular invasion represents an independent risk factor for dismal survival in sorafenib treatment for hepatocellular carcinoma

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Hepatoma Research 2017年第11期3卷 260-267页

作者： Michele Lecchini Andrea Olivani Elisabetta Biasini Raffaele Dalla Valle Carlo Ferrari Gabriele Missale Claudia Schianchi Unit of Infectious Diseases and Hepatology Azienda Ospedaliero-Universitaria di ParmaVia Gramsci1443126ParmaItaly Department of Surgery University of ParmaAzienda Ospedaliero-Universitaria di ParmaVia Gramsci1443126ParmaItaly.

Aim: Sorafenib efficacy and safety in advanced hepatocellular carcinoma (HCC) have been demonstrated in two randomized international clinical trials and in clinical practice studies. Because of poor survival advantage, to identify clinical and biological parameters remains an unmet clinical need. Methods: Eighty-four patients treated with sorafenib were evaluated for response to therapy and prognostic factors possibly associated with survival. Results: Median overall survival was 8.5 months. Median duration of therapy was 2.5 months with a median daily dose of 800 mg (IQR 600-800). Dose was adjusted in 52% of patients. Radiological response to therapy showed a significant impact on survival. Child-Pugh score and neoplastic invasion of the portal system were negatively associated with survival. Continuation of sorafenib even at lower dose was positively correlated with survival. The multivariate analysis identified vascular invasion as the only independent variable: median survival of 5.5 months for neoplastic portal vein thrombosis compared to 12 months in the remaining subjects. Conclusion: A lower sorafenib daily dose is advantageous, even though the reason of this association cannot be explained at present. neoplastic portal vein thrombosis is strongly associated with dismal survival. Alternative or complementary treatment approaches should be studied in order to improve outcome in this subgroup of patients.

关键词： Hepatocellular carcinoma sorafenib neoplastic portal vein thrombosis

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neoplastic pericardial disease: Old and current strategies for diagnosis and management

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World Journal of Cardiology 2010年第9期2卷 270-279页

作者： Chiara Lestuzzi Department of Cardiology Centro di Riferimento Oncologico IRCCS National Cancer Institute Via F. Gallini 2 33081 Aviano (PN) Italy

The prevalence of neoplastic pericardial diseases has changed over time and varies according to diagnostic methods. The diagnostic factor is usually the detection of neoplastic cells within the pericardial fluid or in specimens of pericardium, but the diagnosis may be difficult. Accurate sampling and cytopreparatory techniques, together with ancillary studies, including immunohistochemical tests and neoplastic marker dosage, are essential to obtain a reliable diagnosis. The goals of treatment may be simply to relieve symptoms (cardiac tamponade or dyspnea), to prevent recurrent effusion for a long-term symptomatic benefit, or to treat the local neoplastic disease with the aim of prolonging survival. Immediate relief of symptoms may be obtained with percutaneous drainage or with a surgical approach. For long term prevention of recurrences, various approaches have been proposed: extended drainage, pericardial window (surgical or percutaneous balloon pericardiostomy), sclerosing local therapy, local and/or systemic chemotherapy or radiation therapy (RT) (external or with intrapericardial radionuclides). The outcomes of various therapeutic approaches vary for different tumor types. Lymphoma and leukemias can be successfully treated with systemic chemotherapy; for solid tumors, percutaneous drainage and the use of systemic and/or localsclerosing and antineoplastic therapy seems to offer the best chance of success. The use of "pure" sclerosing agents has been replaced by agents with both sclerosing and antineoplastic activity (bleomycin or thiotepa), which seems to be quite effective in breast cancer, at least when associated with systemic chemotherapy. Local chemotherapy with platinum, mitoxantrone and other agents may lead to good local control of the disease, but the addition of systemic chemotherapy is probably relevant in order to prolong survival. The surgical approach (creation of a pericardial window, even with the mini-invasive method of balloon pericardiostomy)

关键词： neoplastic pericarditis neoplastic pericardial disease Diagnosis Therapy

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Pre-operative factors that can predict neoplastic polypoid lesions of the gallbladder

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World Journal of Gastroenterology 2011年第17期17卷 2216-2222页

作者： Byung Hyo Cha Jin-Hyeok Hwang Sang Hyub Lee Jang Eon Kim Jai Young Cho Haeryoung Kim So Yeon Kim Department of Internal Medicine Cheju Halla General HospitalCheju-siCheju-do 690-766South Korea Departments of Internal Medicine Seoul National University College of Medicine Seoul National University Bundang Hospital Seongnam-siGeonggi-do 463-707South Korea Department of Surgery Seoul National University College of Medicine Department of Pathology Seoul National University College of Medicine Department of Radiology Seoul National University College of Medicine

AIM:To investigate the preoperative factors that can predict neoplastic polypoid lesions of the gallbladder(PLGs) as well as malignant ***:A retrospective analysis was conducted on the 210 consecutively enrolled patients who underwent cholecystectomy due to a PLG larger than 10 mm,as was determined by preoperative trans-abdominal ultrasonography or endoscopic *** ana-lyzed the medical,laboratory,radiologic data and the pathologic ***:In 210 cases,146 had non-neoplastic polyps(69.5%) and 64 cases were neoplastic polyps(30.5%).An older age(≥ 65 years),the presence of diabetes mellitus(DM) and the size of polyp(≥ 15 mm) were revealed to be independent predictive variables for neoplastic polyps with odd ratios(OR) of 2.27(P = 0.044),2.64(P = 0.021) and 4.94(P neoplastic PLGs,an older age(≥ 65 years),the presence of DM and polyp size(≥ 15 mm) were associated with malignancy with ORs of 4.97(P = 0.005),6.13(P = 0.001) and 20.55(P < 0.001),***:Among patients with PLGs larger than 10 mm in size,higher risk groups such as elderly patients more than 65 years old,those with DM or a large polyp size(≥ 15 mm) should be managed by cholecystectomy.

关键词： Gallbladder Polyp neoplastic Cholecystectomy Diabetes Pre-operative factors

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STUDY OF neoplastic TRANSFORMATION OF HUMAN FETAL LUNG CELLS INDUCED BY A NEW NITROSAMINE COMPOUND (MAMBNA) in vitro

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Chinese Science Bulletin 1986年第2期31卷 143-144页

作者：黄明王志华王秀琴吴旻 Cancer Institute Chinese Academy of Medical Sciences Beijing Cancer Institute

The model system of neoplastic transformation of human cells in vitro, as a desirable way for screening potential carcinogens and studying the mechanisms of carcinogenesis, has aroused great interest in a lot of labor... 详细信息

关键词： carcinogenesis screening neoplastic laboratories untreated desirable fetal relate Henan passages

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Effects of a long-term administration of aqueous extract of Prunella vulgaris *** survival,spontaneous thyroid carcinoma and neoplastic C-cell hyperplasia in rats

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China Medical Abstracts(Internal Medicine) 2023年第3期40卷 136-136页

作者：宋佳 Instit Toxicol Guangdong Prov Dis Contr&Prev CenterGuangzhou 51143

Objective To investigate the effects of an aqueous extract of Prunella vulgaris L.(PV)on survival,spontaneous thyroid carcinoma and its preneoplastic lesion in *** A total of 552 Wistar rats were randomly assigned into 4 groups(n=138)and given one of the following diets for 24 months:chow diet(control),2.5(low),8.25(middle)and 25(high)g/kg body weight PV *** the intervention,serum metabolic parameters including indicators of liver and renal function,glucose and lipid profiles were measured.

关键词： neoplastic rats spontaneous

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STUDY OF neoplastic TRANSFORMATION OF HUMAN FETAL KIDNEY EPITHELIAL CELLS INDUCED BY DIETHYL-NITROSAMINE in vitro

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Chinese Science Bulletin 1986年第1期31卷 72-页

作者：黄明王秀琴王志华周传农吴旻 Cancer Institute Chinese Academy of Medical Sciences Beijing Cancer Institute

About 90 percent of human malignant tumors result from the neoplastic transformation of epithelial cells. As the conclusions obtained from animal cells cannot be extrapolated to humans directly, and the humans are not... 详细信息

关键词： neoplastic conclusions allowed untreated inogen abnormal cytoskeleton fetal urgently adoption

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Paraneoplastic cerebellar degeneration:initial presentation of mucosa-associated lymphoid tissue lymphoma in a patient with primary Sjogren’s syndrome

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Chinese Medical Journal 2020年第8期133卷 1005-1007页

作者： Xia Cao Cai-Gang Xu Department of Hematology West China HospitalSichuan UniversityChengduSichuan 610041China

A 29-year-old Chinese woman complained of recurring dizziness for 5 months and gait disturbance for 2 *** admission(April 2016),she was found to have a widebased gait,horizontal nystagmus and positive heel-kneeshin *** hematological,biochemical,microbiological,hormonal investigations and tumor serum markers were *** bands were observed in cerebrospinal fluid(CSF)without other pathological changes,while magnetic resonance imaging(MRI)of cervical spine and brain were *** anterior mediastinal mass was noted by computed tomography(CT)[Figure 1A].Despite a lack of paraneoplastic antibodies in CSF or serum,such as anti-neuronal nuclear autoantibody type 1(ANNA-1,also known as"anti-Hu"),ANNA-2(also known as"anti-Ri"),Purkinje cell antibody type 1(PCA-1,also known as"anti-Yo"),anti-CV2(also known as"collapsin response mediator protein 5[CRMP5]"),anti-Ma,anti-Amphiphysin,anti-Tr(also known as"delta/notch-like epidermal growth factorrelated receptor[DNER]")and anti-glutamic acid decarboxylase(GAD),her neurological manifestation still pointed toward one of the paraneoplastic neurological syndromes(PNSs).

关键词： neoplastic degeneration lymphoid

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Inhibition of Carcinogen-induced Activity of γ-Glutamyl Transpeptidase by Certain Dietary Constituents in Mouse Skin

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Biomedical and Environmental Sciences 1999年第1期12卷 110-115页

作者： YOGESHWER SHUKLA ALKA SINGH AND BHAWNA SRIVASTAVA(Environmental Carcinogenesis Division, Industrial Toxicology Research Centre,P. O. Box 80, M. C. Marg, Lucknow-226 001, India) Environmental Carcinogenesis Division Industrial Toxicology Research Centre Lucknow India

Cancer chemoprevention, a desirable and important facet of biomedical research, Provides a practical approach to identify potentially useful inhibitors of cancer development, and offers an opportunity to study the mechanism of carcinogenesis. During the recent past a nuInber of compounds have been tested for their anticarcinogenic potential specially constituents of human diet. The enzyme y-glutamyl transpeptidase (CGT), which catalyses the transfer of glutamyl gnups of peptides to other peptides and amino acids, has been proposed as a marker of cell proliferation and neoplasia. It also serves as a tool to evaluate the carcinogenic and cocareinogenic poential of environmental toxicants. In the present investigations, GGT activity induced by carcinogenic polycyclic aromatic hydrocarbons, viz. 7, 12-dimethyl-benz(a) anthracene (DMBA) and benzo(a)Pyrene (BaP was significantly inhibited by diallylsulfide (DAS) and indole-3-carbinol (13C) in mouse skin. DAS and 13C are Constituents of garlic. A significant inhibition in GGT levels was also observed in a strong mitogen (12-o-tetradecanoyl phorbol-13-acelate) induced activity by pretreatment of DAS/13C in mouse skin. Therefore these dielary constituents seem to be strong modifiers of chemically induced carcinogenesis.

关键词： Allyl Compounds Animals Anticarcinogenic Agents Carcinogens Cell Transformation neoplastic Diet Female Garlic Hydrocarbons Aromatic Indoles Mice Plants Medicinal Sulfides gamma-Glutamyltransferase

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