检索结果-南通市图书馆

维普期刊数据库

PGC-1α-mediated imbalance of mitochondria-lipid droplet homeostasis in neomycin-induced ototoxicity and nephrotoxicity

在线全文

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2024年第10期14卷 4413-4430页

作者： Bin Chen Cheng Cheng Yunhao Wu Siyu Li Mo Han Le Zhen Ying Peng Suhan Guo Kaidi Shen Xia Gao Renjie Chai Guangji Wang Fang Zhou Key Laboratory of Drug Metabolism and Pharmacokinetics State Key Laboratory of Natural MedicinesChina Pharmaceutical UniversityNanjing 210009China Department of Otolaryngology Head and Neck Surgery Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjing 210096China Co-Innovation Center of Neuroregeneration Nantong UniversityNantong 226001China Medical Science and Technology Innovation Center Shandong First Medical University&Shandong Academy of Medical SciencesJinan 250117China State Key Laboratory of Digital Medical Engineering Department of Otolaryngology Head and Neck SurgeryZhongda HospitalSchool of Life Sciences and TechnologyAdvanced Institute for Life and HealthJiangsu Province High-Tech Key Laboratory for Bio-Medical ResearchSoutheast UniversityNanjing 210096China Department of Neurology Aerospace Center HospitalSchool of Life ScienceBeijing Institute of TechnologyBeijing 100081China

Ototoxicity and nephrotoxicity are the most prevalent side effects of aminoglycoside antibiotics(gentamicin,amikacin,neomycin)and platinum anti-tumor drugs(cisplatin,carboplatin).The inner ear and kidney share similarities in drug deposition and toxicity,but the underlying pathophysiological mechanisms remain *** the shared mechanisms and metabolic alterations in these distinct organs will provide valuable insights for clinical therapy.A strong correlation has been identified between the spatiotemporal accumulation patterns of neomycin and the specific occurrence of lipid metabolism disorders in these two *** primary allocation of neomycin to mitochondria results in a notable escalation in the accumulation of lipid droplets(LDs)and more interactions between mitochondria and LDs,leading to a sequence of disturbances in lipid metabolism,such as increased lipid ROS and the blocked transfer of fatty acids from LDs to ***-1αdeficiency worsens the neomycin-induced disorders in lipid metabolism and intensifies the pathological interactions between mitochondria and LDs,as indicated by the exacerbated disturbance of dynamic LD turnover,increased level of oxidized lipids and decreased use of fatty *** investigation provides a fresh perspective on the lipid metabolic dysfunction related to mitochondria-LD interactions in drug-induced ototoxicity and nephrotoxicity,potentially providing novel avenues for intervention strategies.

关键词： Mitochondria neomycin Nephrotoxicity Ototoxicity Lipid metabolism Triacylglycerol PGC-1α PLIN3

Determination of neomycin in water samples by high performance anion chromatography with pulsed amperometric detection

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2007年第2期18卷 201-204页

作者： Bin Guan Dong Xing Yuan Environmental Science Research Center Xiamen University Xiamen 361005 China

A simple, fast and reliable method, using high performance anion chromatography with pulsed amperometric detection, had been developed for the analysis of neomycin in water samples. The elution and separation were carried out with an isocratic mobile phase, containing 10 mmol/L NaOH. The influence of the concentration and pH of the mobile phase on the separation and detection was investigated. A quadruple-potential waveform used for the detection was optimized. The detection limit of neomycin was down to 0.027 μg/mL. The linearity of neomycin calibration curve ranged from 0.050 to 0.505 μg/mL with correlation coefficient of 0.9997. R.S.D. (n = 11) was 4.0%.

关键词： neomycin High performance anion chromatography Pulsed amperometric detection

维普期刊数据库

Follicular contact dermatitis revisited: A review emphasizing neomycin-associated follicular contact dermatitis

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2014年第12期2卷 815-821页

作者： Philip R Cohen Division of Dermatology University of California San Diego San Diego CA 92131-3643 United States

Follicular contact dermatitis clinically presents as individual papules that include a central hair follicle. Pathologic features involve the follicle and the surrounding dermis: spongiosis and vesicle formation of the follicular epithelium associated with perifollicular and perivascular lymphocytic inflammation. Using the Pub Med database, an extensive literature search was performed on follicular contact dermatitis and neomycin. Relevant papers were reviewed and the clinical and pathologic features, the associated chemicals(including a more detailed description of neomycin), the hypothesized pathogenesis, and the management of follicular contact dermatitis were described. Several agentseither as allergens or irritants-have been reported to elicit follicular contact dermatitis. Several hypotheses have been suggested for the selective involvement of the follicles in follicular contact dermatitis: patient allergenicity, characteristics of the agent, vehicle containing the agent, application of the agent, and external factors. The differential diagnosis of follicular contact dermatitis includes not only recurrent infundibulofolliculitis, but also drug eruption, mite infestation, viral infection, and dermatoses that affect hair follicles. The primary therapeutic intervention for follicular contact dermatitis is withdrawal of the causative agent; treatment with a topical corticosteroid preparation may also promote resolution of the dermatitis. In conclusion, follicular contact dermatitis may be secondary to allergens or irritants; topical antibiotics, including neomycin, may cause this condition. Several factors may account for the selective involvement of the hair follicle in this condition. Treatment of the dermatitis requires withdrawal of the associated topical agent; in addition, topical corticosteroids may be helpful to promote resolution of lesions.

关键词： Allergic Contact Dermatitis Follicular Irritant neomycin Papular

Results of selective decontamination with oral neomycin and metronidazole for major colorectal surgery in Australia:A cohort study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Laparoscopic, Endoscopic and Robotic Surgery 2024年第2期7卷 72-78页

作者： James Wei Tatt Toh Devansh Shah Henry Wang Charlotte Kwik Joseph Do Woong Choi Chelsie Leonie Beinke Paul Morris Eleni Baird-Gunning Geoffrey Peter Collins Fiona Gavegan Karen Shedden Toufic El-Khoury Nimalan Pathma-Nathan Kerry Hitos Department of Colorectal Surgery Westmead HospitalWestmeadNew South WalesAustralia The University of Sydney Westmead HospitalWestmeadNew South WalesAustralia Western Sydney University New South WalesAustralia University of Notre Dame New South WalesAustralia Westmead Research Centre for Evaluation of Surgical Outcomes Westmead HospitalSydneyAustralia

Objective The role of selective decontamination with oral antibiotics(OABs)and mechanical bowel preparation(MBP)prior to elective colorectal surgery is still widely *** objective of this study was to compare the outcomes of selective decontamination with neomycin,metronidazole and MBP compared to those of decontamination with MBP alone or with no *** Selective decontamination with neomycin and metronidazole combined with bowel preparation was introduced prior to elective colorectal surgery as part of an enhanced recovery after surgery program at Westmead Hospital,a major Australian tertiary referral hospital,between June 2017 and January *** between short-term outcomes of OAB+MBP and MBP/no preparation were made using prospectively collected data on length of stay(LOS),readmission,mortality within 30 days,anastomotic leakage(AL),surgical site infection(SSI),urinary tract infection,deep venous thrombosis and/or pulmonary embolism,pneumonia,and ***-up was limited to hospital stays and subsequent presentations within the health district within thirty days of *** Mann-Whitney U test was used to analyse continuous data,and the chi-square test was used for categorical *** and multivariate regression modelling was performed to identify risk factors associated with an increased likelihood of SSI and *** Patients with oral neomycin and metronidazole combined with bowel preparation had reduced superficial SSI(2.7%vs.7.6%,p=0.043)and overall complications(32.7%vs.44.6%,p=0.020),particularly Clavien-Dindo 1 complications(7.3%vs.16.5%,p=0.009).However,the differences in AL(2.7%vs.4.5%,p=0.369)and organ/space SSI(1.3%vs.3.7%,p=0.327)were not statistically *** median LOS(6 d vs.6 d,p=0.370)was not different between the *** Selective decontamination with neomycin and metronidazole reduces the risk of SSIs and overall *** was a trend to toward a lower AL,but this differ

关键词： neomycin Metronidazole Colorectal surgery Anastomotic leakage Surgical site infection

Binding of PLCδ1PH-GFP to Ptdlns(4,5)P2 prevents inhibition of phospholipase C-mediated hydrolysis of Ptdlns(4,5)P2 by neomycin

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Pharmacologica Sinica 2005年第12期26卷 1485-1491页

作者： Chuan WANG Xiao-na DU Qing-zhong JIA Hai-lin ZHANG~2 Department of Pharmacology Hebei Medical University,Shijiazhuang 050017,China Department of Pharmacology Hebei Medical University Shijiazhuang 050017 China

Aim:To investigate the effects of the pleckstrin homology(PH)domain of phos-pholipase Cδ1(PLCδ1PH)on inhibition of phospholipase C(PLC)-mediated hy-drolysis of phosphatidylinositol 4,5-bisphosphate[PtdIns(4,5)P2]by ***:A fusion construct of green fluorescent protein(GFP)and PLCδ1PH(PLCδ1PH-GFP),which is known to bind PtdIns(4,5)P2specifically,together withlaser-scanning confocal microscopy,was used to trace PtdIns(4,5)***:Stimulation of the type 1 muscarinic receptor and the bradykinin 2 recep-tor induced a reversible PLCδ1PH-GFP translocation from the membrane to thecytosol in COS-7 *** inhibitor U73122 blocked the ***,a known PtdIns kinase inhibitor,did not affect the translocationinduced by ACh,but blocked recovery after translocation,indicating thatPtdIns(4,5)P2hydrolysis occurs through receptor-mediated PLC ***,a commonly used phospholipase C blocker,failed to block the recep-tor-induced PLCδ1PH-GFP translocation,indicating that neomycin is unable toblock PLC-mediated Ptdlns(4,5)Pe ***,in the absence of PLCδ1PH-GFP expression,neomycin abolished the receptor-induced hydrolysis ofPtdIns(4,5)P2 by ***:Although PLCδ1PH and neomycin bind toPtdIns(4,5)P2 in a similar way,they have distinct effects on receptor-mediatedactivation of PLC and PtdIns(4,5)P2 hydrolysis.

关键词： phosphatidylinositol 4,5-bisphosphate neomycin phospholipase C pleckstrin homology domains competitive binding acetylcholine green fluorescent proteins

Synergistic Effect of Silver Nanoparticles with neomycin or Gentamicin Antibiotics on Mastitis-Causing Staphylococcus aureus

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Ecology 2016年第7期6卷 452-459页

作者： Shahab Jamaran Bahareh Rahimian Zarif Department of Biology Sanandaj Branch Islamic Azad University Sanandaj Iran

Objective: Mastitis is one of the most costly diseases in dairy cows, which greatly decreases milk production. Use of antibiotics in cattle leads to antibiotic-resistance of mastitis-causing bacteria. The present study aimed to investigate synergistic effect of silver nanoparticles (AgNPs) with neomycin or gentamicin antibiotic on mastitis-causing Staphylococcus aureus. Materials and Methods: In this study, 46 samples of milk were taken from the cows with clinical and subclinical mastitis during the august-October 2015 sampling period. In addition to biochemical tests, nuc gene amplification by PCR was used to identify strains of Staphylococcus aureus. Disk diffusion test and microdilution were performed to determine minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). Fractional Inhibitory Concentration (FIC) index was calculated to determine the interaction between a combination of AgNPs and each one of the antibiotics. Results: Twenty strains of Staphylococcus aureus were isolated from 46 milk samples and were confirmed by PCR. Based on disk diffusion test, 35%, 10% and 55% of the strains were respectively susceptible, moderately susceptible and resistant to gentamicin. In addition, 35%, 15% and 50% of the strains were respectively susceptible, moderately susceptible and resistant to neomycin. According to FIC index, gentamicin antibiotic and AgNPs had synergistic effects in 50% of the strains. Furthermore, neomycin antibiotic and AgNPs had synergistic effects in 45% of the strains. Conclusion: It could be concluded that a combination of AgNPs with either gentamicin or neomycin showed synergistic antibacterial properties in Staphylococcus aureus isolates from mastitis. In addition, some hypotheses were proposed to explain antimicrobial mechanism of the combination.

关键词： Staphylococcus aureus Mastitis Silver Nanoparticles Gentamicin neomycin Synergistic

Effects of 1-Butanol、neomycin and Calcium on Photosynthetic Characteristics of Transgenic Rice Plants Overexpressing Maize Phosphoenopyruvate Carboxylase

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effects of 1-Butanol、Neomycin and Calcium on Photosynthetic...

中国植物生理学会第十次会员代表大会暨全国学术年会

作者： Li Xia*, Wang Chao Institute of Foods Crop, Jiangsu Academy of Agriculture Sciences, Nanjing 210014,China *Corresponding author

＜正＞The maize gene encoding phosphoenolpymvate carboxylase（pepc）, one of the key enzyme in C4 photosynthetic pathway, has been introduced into C3 crop rice and high-level expression of the pepc gene was observed in

关键词： Rice PEPC 1-Butanol neomycin Photosynthesis Stomata

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

生物技术通讯 1994年第3期5卷 143-143页

作者：郭葆玉胡宗林徐惠敏孔宪涛陆德如第二军医大学医学生物技术和分子遗传研究所上海200433

腺相关病毒(AAV,Adeno associated Virus)是一类线状单股DNA的微小病毒。腺相关病毒因共具有定点整合(19q13 qter)及非病原性等特点而在基因转移与治疗中可望作为较为理想的载体。其在宿主染色体DNA上的整合需要辅助病毒共转染。根据Cav... 详细信息

腺相关病毒(AAV,Adeno associated Virus)是一类线状单股DNA的微小病毒。腺相关病毒因共具有定点整合(19q13 qter)及非病原性等特点而在基因转移与治疗中可望作为较为理想的载体。其在宿主染色体DNA上的整合需要辅助病毒共转染。根据Cavalier-Smith的线状SS DNA分子复制模式,即复制过程中3′OH端作为引物在DNA聚合酶的作用下合成另一姊妹股DNA分子,然后共价地连接到亲代未折叠的5′端回纹末端而进行DNA复制。

关键词：腺相关病毒 ITRs neomycin 染色体基因 DNA 末端反向重复折叠结构非病原性聚合酶辅助病毒

维普期刊数据库

口服新霉素(neomycin)和土霉素(Terramycin)对肠内细菌的作用

在线全文

学校读者我要写书评

暂无评论

人民军医 1954年第7期 9-9页

作者：冯培

美奥诊所以前所进行的研究证明,金霉素和土霉素有排除肠内细菌的效力,但用药後却有抗药性的葡萄球菌形成,并引起局部和全身症状。这些抗药性的葡萄球菌对新霉素则有感受性,著者在本文介绍,新霉素在单独使用和与土霉素并用时,对肠内细菌... 详细信息

美奥诊所以前所进行的研究证明,金霉素和土霉素有排除肠内细菌的效力,但用药後却有抗药性的葡萄球菌形成,并引起局部和全身症状。这些抗药性的葡萄球菌对新霉素则有感受性,著者在本文介绍,新霉素在单独使用和与土霉素并用时,对肠内细菌的效力。在37名因各种肠管疾患而需行手术治疗的病人中,均予新霉素口服。其中34人在2—3日内,粪内便无需氧菌;而在其馀3人中,则分别有粪

关键词：葡萄球菌 neomycin Terramycin 需氧菌