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INHIBITORY EFFECT OF ANGIOTENSIN II TYPE 1 RECEPTOR-ASSOCIATED PROTEIN ON VASCULAR SMOOTH MUSCLE CELL GROWTH AND neointimal formation

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Chinese Medical Sciences Journal 2007年第1期22卷 22-26页

作者： Zhen Li Zhong-gao Wang Xiu Chen Xiao-dong Chen Department of Vascular Surgery the Second Artillery General Hospital Beijing 100088 Department of General Lab and Vascular Surgery the First Affiliated Hospital of Guangdong Medical College Zhanjiang 524001 Department of Surgery Vascular Institute and Xuanwu Hospital Capital University of Medical Sciences Beijing 100053

Objective To investigate the mechanism of a novel angiotensin Ⅱ type 1 receptor-associated protein （ATRAP） interfering with angiotensin Ⅱ type 1 （AT1） receptor-mediated vascular smooth muscle cell （VSMC） growth and neointimal formation. Methods VSMCs isolated from thoracic aorta of adult Sprague-Dawley （SD） rats were used in this study. ATRAP cDNA was subcloned into pcDNA3 vector and then transfected into VSMCs. DNA synthesis and extracellular signal-regulated kinase （ERK） and phospho-ERK expressions in VSMCs were assayed by measurement of ^3H thymidine incorporation and Western blotting, respectively. Morphological changes were observed in the balloon injured artery with or without transfection of ATRAP cDNA using 12-week-old male SD rats. Results ATRAP overexpression in VSMCs inhibited angiotensin Ⅱ （Ang Ⅱ）-induced ^3H thymidine incorporation 48 hours after Ang Ⅱ stimulation （ P 〈 0. 05 ）. In VSMC, Ang Ⅱ stimulation increased the phosphorylation of ERK, which reached the peak around 60 minutes. The activation of phospho-ERK was significantly decreased by ATRAP （ P 〈 0. 05 ）. neointimal formation was markedly inhibited by ATRAP overexpression in injuried arteries.Conclusions The AT1 receptor-derived activation of ERK plays an essential role in Ang Ⅱ-induced VSMC growth. The growth inhibitory effects of ATRAP might be due to interfering with AT1 receptor-mediated activation of ERK in VSMC growth and neointimal formation.

关键词： angiotensin receptor vascular smooth muscle cell neointimal formation

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The Role of Progenitor Cells in the Pathogenesis of Arteriosclerosis

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Cardiology Discovery 2024年第3期4卷 231-244页

作者： Yuesheng Zhang Ziyin Guan Hui Gong Zhichao Ni Qingzhong Xiao Xiaogang Guo Qingbo Xu Department of Cardiology the First Affiliated HospitalZhejiang UniversitySchool of MedicineHangzhouZhejiang 310000China Centre for ClinicalPharmacology and Precision Medicine William Harvey Research InstituteFacultyof Medicine and DentistryQueen Mary University of LondonLondonUnitedKingdom

The increasing incidence of arteriosclerosis has become a significant global health *** is characterized by the thickening and hardening of arterial walls,which can lead to the narrowing or complete blockage of blood ***,the pathogenesis of the disease remains incompletely *** research has shown that stem and progenitor cells found in the bone marrow and local vessel walls play a role in the development of arteriosclerosis by differentiating into various types of vascular cells,including endothelial cells,smooth muscle cells,fibroblasts,and inflammatory *** review aims to provide a comprehensive understanding of the role of stem and progenitor cells in the pathogenesis of arteriosclerosis,shedding light on the underlying mechanisms and potential therapeutic approaches for this disease.

关键词： Stem cells Vascular progenitors Endothelial repair neointimal formation Arteriosclerosis

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