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Critical prognostic value of the log odds of negative lymph nodes/tumor size in rectal cancer patients

World Journal of Clinical Cases 2021年第15期9卷 3531-3545页

作者： Jie-Bin Xie Yue-Shan Pang Xun Li Xiao-Ting Wu Department of Gastrointestinal Surgery West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Gastrointestinal Surgery Affiliated Hospital of North Sichuan Medical College ChinaNanchong 637200Sichuan ProvinceChina Department of Geriatrics The Second Clinical Medical College of North Sichuan Medical CollegeNanchong Central HospitalNanchong 637200Sichuan ProvinceChina

BACKGROUND The number of negative lymph nodes(NLNs)and tumor size are associated with prognosis in rectal cancer patients undergoing surgical ***,little is known about the prognostic significance of the NLN count after adjusting for tumor *** To assess the prognostic impact of the log odds of NLN/tumor size(LONS)in rectal cancer *** Data of patients with stage I–III rectal cancer were extracted from the Surveillance,Epidemiology,and End Results Program *** patients were randomly divided into a training cohort and a validation *** and multivariate Cox regression analyses were used to determine the prognostic value of the *** optimal cutoff values of LONS were calculated using the"X-tile"*** analysis of the effect of LONS on cancer-specific survival(CSS)and overall survival(OS)were *** Kaplan-Meier method with the log-rank test was used to plot the survival curve and compare the survival data among the different *** In all,41080 patients who met the inclusion criteria were randomly divided into a training cohort(n=28775,70%)and a validation cohort(n=12325,30%).Univariate and multivariate analyses identified the continuous variable LONS as an independent prognostic factor for CSS[training cohort:Hazard ratio(HR)=0.47,95%confidence interval(CI):0.44–0.51,Ptumor-node-metastasis stage,site,age,sex,the number of examined lymph nodes,race,preoperative ra

关键词： Rectal cancer negative lymph nodes negative lymph nodes/tumor size Prognosis Survival analysis Surveillance,Epidemiology,and End Results Program

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